Patent ductus arteriosus epidemiology and demographics: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Patent ductus arteriosus}} | {{Patent ductus arteriosus}} | ||
{{CMG}}; '''Associate Editor-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], {{CZ}}, '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | {{CMG}}; '''Associate Editor-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], {{CZ}}, {{RG}}'''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | ||
==Overview== | ==Overview== | ||
The PDA is commonly found in [[infant]]s and constitutes only 2% of all congenital defects found in adults. The [[incidence]] is greater is in children who are born prematurely with history of [[perinatal asphyxia]] and [[infant]]s with [[congenital rubella]]. | The [[Patent ductus arteriosus]] ([[Patent ductus arteriosus|PDA]]) is commonly found in [[infant]]s and constitutes only 2% of all [[congenital defects]] found in adults. The [[incidence]] is greater is in children who are born [[Premature|prematurely]] with history of [[perinatal asphyxia]] and [[infant]]s with [[congenital rubella]]. | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
===Prevalence=== | ===Prevalence=== | ||
*The PDA is commonly found in [[infant]]s and constitutes only 2% of all congenital defects found in adults. | *The [[Patent ductus arteriosus|PDA]] is commonly found in [[infant]]s and constitutes only 2% of all [[congenital defects]] found in adults.<ref name="El Hajjar2005">{{cite journal|last1=El Hajjar|first1=M|title=Severity of the ductal shunt: a comparison of different markers|journal=Archives of Disease in Childhood - Fetal and Neonatal Edition|volume=90|issue=5|year=2005|pages=F419–F422|issn=1359-2998|doi=10.1136/adc.2003.027698}}</ref><ref name="pmid18657826">{{cite journal| author=Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A| title=Prevalence of congenital heart defects in metropolitan Atlanta, 1998-2005. | journal=J Pediatr | year= 2008 | volume= 153 | issue= 6 | pages= 807-13 | pmid=18657826 | doi=10.1016/j.jpeds.2008.05.059 | pmc=2613036 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18657826 }}</ref><ref name="pmid22078432">{{cite journal| author=van der Linde D, Konings EE, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJ | display-authors=etal| title=Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. | journal=J Am Coll Cardiol | year= 2011 | volume= 58 | issue= 21 | pages= 2241-7 | pmid=22078432 | doi=10.1016/j.jacc.2011.08.025 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22078432 }}</ref><ref name="pmid17990334">{{cite journal| author=Riehle-Colarusso T, Strickland MJ, Reller MD, Mahle WT, Botto LD, Siffel C | display-authors=etal| title=Improving the quality of surveillance data on congenital heart defects in the metropolitan Atlanta congenital defects program. | journal=Birth Defects Res A Clin Mol Teratol | year= 2007 | volume= 79 | issue= 11 | pages= 743-53 | pmid=17990334 | doi=10.1002/bdra.20412 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17990334 }}</ref> | ||
*It is an isolated defect in 75% of cases, and is isolated in almost all adult cases. | *It is an isolated defect in 75% of cases, and is isolated in almost all adult cases. | ||
===Incidence=== | ===Incidence=== | ||
*In the United States, the estimated incidence in children born at term is between | *In the United States, the estimated [[incidence]] in children born at term is between 3 to 8 per 10,000 live births.<ref name="Clyman2000">{{cite journal|last1=Clyman|first1=Ronald I.|title=Ibuprofen and Patent Ductus Arteriosus|journal=New England Journal of Medicine|volume=343|issue=10|year=2000|pages=728–730|issn=0028-4793|doi=10.1056/NEJM200009073431009}}</ref><ref name="pmid12084585">{{cite journal| author=Hoffman JI, Kaplan S| title=The incidence of congenital heart disease. | journal=J Am Coll Cardiol | year= 2002 | volume= 39 | issue= 12 | pages= 1890-900 | pmid=12084585 | doi=10.1016/s0735-1097(02)01886-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12084585 }}</ref> | ||
*The incidence of patent ductus arteriosus has increased over the past few decades. This is in part due to increased survival in the [[premature]] infants. | *The [[incidence]] of [[patent ductus arteriosus]] has increased over the past few decades. This is in part due to increased survival in the [[premature]] infants. | ||
*The incidence is greater in children who are born- | *The [[incidence]] is greater in children who are born:<ref name="pmid7671547">{{cite journal| author=Hammerman C| title=Patent ductus arteriosus. Clinical relevance of prostaglandins and prostaglandin inhibitors in PDA pathophysiology and treatment. | journal=Clin Perinatol | year= 1995 | volume= 22 | issue= 2 | pages= 457-79 | pmid=7671547 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7671547 }}</ref><ref name="pmid16322141">{{cite journal| author=Tanner K, Sabrine N, Wren C| title=Cardiovascular malformations among preterm infants. | journal=Pediatrics | year= 2005 | volume= 116 | issue= 6 | pages= e833-8 | pmid=16322141 | doi=10.1542/peds.2005-0397 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16322141 }}</ref><ref name="pmid19591690">{{cite journal| author=Forsey JT, Elmasry OA, Martin RP| title=Patent arterial duct. | journal=Orphanet J Rare Dis | year= 2009 | volume= 4 | issue= | pages= 17 | pmid=19591690 | doi=10.1186/1750-1172-4-17 | pmc=2716300 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19591690 }}</ref> | ||
**Prematurely, with a history of [[perinatal asphyxia]] | **Prematurely, with a history of [[perinatal asphyxia]], perinatal asphyxia delays the closure of the ductus. | ||
**Increased incidences in infants with [[congenital rubella]]. | **Approximately, 20% of neonates with [[respiratory distress syndrome]] have a [[patent ductus arteriosus]]. | ||
**Children born at high altitude. | **In babies who are less than 1500 g at [[birth]], many studies show the incidence of a PDA to exceed 30%. | ||
**The increased patency in these groups is thought to be due to both [[hypoxia]] in babies with [[respiratory distress]] and premature ductal closure mechanisms in premature babies. | |||
**Increased [[Incidence|incidences]] in infants with [[congenital rubella]]. | |||
**Children born at [[high altitude]]. | |||
===Gender=== | ===Gender=== | ||
*The female-to-male ratio is | *Females are more commonly affected by [[Patent ductus arteriosus|PDA]] than males. The female-to-male ratio is approximately 2:1.<ref name="RecordMcKeown1953">{{cite journal|last1=Record|first1=R. G.|last2=McKeown|first2=T.|title=OBSERVATIONS RELATING TO THE AeTIOLOGY OF PATENT DUCTUS ARTERIOSUS|journal=Heart|volume=15|issue=4|year=1953|pages=376–386|issn=1355-6037|doi=10.1136/hrt.15.4.376}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 21:12, 9 March 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Priyamvada Singh, M.B.B.S. [2], Cafer Zorkun, M.D., Ph.D. [3], Ramyar Ghandriz MD[4]Assistant Editor-In-Chief: Kristin Feeney, B.S. [5]
Overview
The Patent ductus arteriosus (PDA) is commonly found in infants and constitutes only 2% of all congenital defects found in adults. The incidence is greater is in children who are born prematurely with history of perinatal asphyxia and infants with congenital rubella.
Epidemiology and Demographics
Prevalence
- The PDA is commonly found in infants and constitutes only 2% of all congenital defects found in adults.[1][2][3][4]
- It is an isolated defect in 75% of cases, and is isolated in almost all adult cases.
Incidence
- In the United States, the estimated incidence in children born at term is between 3 to 8 per 10,000 live births.[5][6]
- The incidence of patent ductus arteriosus has increased over the past few decades. This is in part due to increased survival in the premature infants.
- The incidence is greater in children who are born:[7][8][9]
- Prematurely, with a history of perinatal asphyxia, perinatal asphyxia delays the closure of the ductus.
- Approximately, 20% of neonates with respiratory distress syndrome have a patent ductus arteriosus.
- In babies who are less than 1500 g at birth, many studies show the incidence of a PDA to exceed 30%.
- The increased patency in these groups is thought to be due to both hypoxia in babies with respiratory distress and premature ductal closure mechanisms in premature babies.
- Increased incidences in infants with congenital rubella.
- Children born at high altitude.
Gender
- Females are more commonly affected by PDA than males. The female-to-male ratio is approximately 2:1.[10]
References
- ↑ El Hajjar, M (2005). "Severity of the ductal shunt: a comparison of different markers". Archives of Disease in Childhood - Fetal and Neonatal Edition. 90 (5): F419–F422. doi:10.1136/adc.2003.027698. ISSN 1359-2998.
- ↑ Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A (2008). "Prevalence of congenital heart defects in metropolitan Atlanta, 1998-2005". J Pediatr. 153 (6): 807–13. doi:10.1016/j.jpeds.2008.05.059. PMC 2613036. PMID 18657826.
- ↑ van der Linde D, Konings EE, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJ; et al. (2011). "Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis". J Am Coll Cardiol. 58 (21): 2241–7. doi:10.1016/j.jacc.2011.08.025. PMID 22078432.
- ↑ Riehle-Colarusso T, Strickland MJ, Reller MD, Mahle WT, Botto LD, Siffel C; et al. (2007). "Improving the quality of surveillance data on congenital heart defects in the metropolitan Atlanta congenital defects program". Birth Defects Res A Clin Mol Teratol. 79 (11): 743–53. doi:10.1002/bdra.20412. PMID 17990334.
- ↑ Clyman, Ronald I. (2000). "Ibuprofen and Patent Ductus Arteriosus". New England Journal of Medicine. 343 (10): 728–730. doi:10.1056/NEJM200009073431009. ISSN 0028-4793.
- ↑ Hoffman JI, Kaplan S (2002). "The incidence of congenital heart disease". J Am Coll Cardiol. 39 (12): 1890–900. doi:10.1016/s0735-1097(02)01886-7. PMID 12084585.
- ↑ Hammerman C (1995). "Patent ductus arteriosus. Clinical relevance of prostaglandins and prostaglandin inhibitors in PDA pathophysiology and treatment". Clin Perinatol. 22 (2): 457–79. PMID 7671547.
- ↑ Tanner K, Sabrine N, Wren C (2005). "Cardiovascular malformations among preterm infants". Pediatrics. 116 (6): e833–8. doi:10.1542/peds.2005-0397. PMID 16322141.
- ↑ Forsey JT, Elmasry OA, Martin RP (2009). "Patent arterial duct". Orphanet J Rare Dis. 4: 17. doi:10.1186/1750-1172-4-17. PMC 2716300. PMID 19591690.
- ↑ Record, R. G.; McKeown, T. (1953). "OBSERVATIONS RELATING TO THE AeTIOLOGY OF PATENT DUCTUS ARTERIOSUS". Heart. 15 (4): 376–386. doi:10.1136/hrt.15.4.376. ISSN 1355-6037.