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'''Paromomycin sulfate''' (brand name '''Humatin''') is a drug that fights intestinal infections such as [[cryptosporidiosis]] and amoeba infection, or [[amoebiasis]] and was developed as a therapeutic against [[visceral leishmaniasis]] by the [[Institute for OneWorld Health]]. Paromomycin was granted [[orphan drug]] status in 2005<ref>{{cite press release
'''Paromomycin sulfate''' (brand name '''Humatin''') is a drug that fights intestinal infections such as [[cryptosporidiosis]] and amoeba infection, or [[amoebiasis]] and was developed as a therapeutic against [[visceral leishmaniasis]] by the [[Institute for OneWorld Health]]. Paromomycin was granted [[orphan drug]] status in 2005<ref>{{cite press release
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Revision as of 14:47, 20 August 2012

Paromomycin sulfate
Error creating thumbnail: File missing
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Oral, intramuscular
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityNone
MetabolismNone
Elimination half-life?
ExcretionFecal
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC23H47N5O18S
Molar mass615.629 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Paromomycin sulfate (brand name Humatin) is a drug that fights intestinal infections such as cryptosporidiosis and amoeba infection, or amoebiasis and was developed as a therapeutic against visceral leishmaniasis by the Institute for OneWorld Health. Paromomycin was granted orphan drug status in 2005[1] and was approved by the Drug Controller General of India in September 2006 for treatment of visceral leishmaniasis.[2]

Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA.[3]

References

  1. "Institute for OneWorld Health Drug Receives "Orphan" Designation From U.S. and European Regulatory Agencies" (Press release). Institute for OneWorld Health. 23 May 2005. Retrieved 2007-02-10.
  2. "New cure for deadly visceral leishmaniasis (kala-azar) approved by government of India" (Press release). Institute for OneWorld Health. 8 September 2006. Retrieved 2007-02-10.
  3. Vicens, Quentin (2001). "Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site". Structure. 9 (8): 647&ndash, 658. doi:10.1016/S0969-2126(01)00629-3. PMID 11587639. Retrieved 2007-02-10. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (help)

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