Parathyroid adenoma (patient information)
|
Parathyroid adenoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Parathyroid adenoma (patient information) On the Web |
|
American Roentgen Ray Society Images of Parathyroid adenoma (patient information) |
|
Risk calculators and risk factors for Parathyroid adenoma (patient information) |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Syed Musadiq Ali M.B.B.S.[2]
Overview
A parathyroid adenoma is a benign tumor of the parathyroid gland. Parathyroid adenoma can be associated with overexpression of the cyclin D1 gene. An elevated concentration of serum calcium and serum parathyroid hormone is diagnostic of parathyroid gland. A specific test for parathyroid adenoma is sestamibi parathyroid scintigraphy, the sestamibi scan. Surgery is the mainstay of treatment for parathyroid cancer..
What are the symptoms of Parathyroid adenoma?
- Back pain
- Blurred vision (because of cataracts)
- Bone pain or tenderness
- Decreased height
- Depression
- Fatigue
- Fractures of long bones
- Increased urine output
- Increased thirst
- Itchy skin
- Joint pain
- Loss of appetite
- Nausea
- Muscle weakness and pain
- Personality changes
- Stupor and possibly coma
- Upper abdominal pain
What causes Parathyroid adenoma?
The parathyroid glands are located in the neck, near or attached to the back side of the thyroid gland. They produce parathyroid hormone, which controls calcium, phosphorus, and vitamin D levels within the blood and bone.
When calcium levels are too low, the body responds by increasing production of parathyroid hormone. This increase in parathyroid hormone causes more calcium to be taken from the bone and more calcium to be reabsorbed by the intestines and kidney. When the calcium level returns to normal, parathyroid hormone production slows down.
There are two main types of Parathyroid adenoma.
Primary hyperparathyroidism is caused by enlargement of one or more of the parathyroid glands. This leads to too much parathyroid hormone, which raises the level of calcium in the blood. The term "hyperparathyroidism" generally refers to primary hyperparathyroidism.
Secondary hyperparathyroidism is when the body produces extra parathyroid hormone because the calcium levels are too low. This is seen when vitamin D levels are low or when calcium is not absorbed from the intestines. Correcting the calcium level and the underlying problem will bring the parathyroid levels in the normal range.
If the parathyroid glands continue to produce too much parathyroid hormone even though the calcium level is back to normal, the condition is called "tertiary hyperthyroidism." It occurs especially in patients with kidney problems
Diagnosis
Blood tests will be done to check for increased levels of parathyroid hormone (PTH), calcium, and alkaline phosphatase, and lower levels of phosphorus. A 24-hour urine collection test can help determine how much calcium is being removed from the body.
Bone x-rays and bone mineral density test can help detect bone loss, fractures, or bone softening.
X-rays, ultrasound, or CT scans of the kidneys or urinary tract may show calcium deposits or a blockage.
When to seek urgent medical care?
Call for an appointment with your health care provider if you have symptoms of hyperparathyroidism.
Treatment options
Treatment depends upon the severity and cause of the condition. If you have mildly increased calcium levels due to primary hyperparathyroidism and no symptoms, you may just need regular checkups with your doctor.
If symptoms are present or your calcium level is very high, surgery may be needed to remove the parathyroid gland that is overproducing the hormone.
Treatment of Parathyroid adenoma depends on the underlying cause.
Possible complications
Complications may include:
- Increased risk of fractures
- Urinary tract infection due to kidney stones and blockage
- Peptic ulcer disease
- Pancreatitis
- Pseudogout
Surgery for Parathyroid adenoma may lead to low blood calcium levels, which causes tingling and muscle twitching. This requires immediate treatment.
Sources
http://www.nlm.nih.gov/medlineplus/ency/article/001215.htm Template:WH Template:WS