Paraneoplastic syndrome (patient information): Difference between revisions
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==Overview== | ==Overview== | ||
A '''paraneoplastic syndrome''' is a [[disease]] or [[symptom]] that is the consequence of the presence of [[cancer]] in the body, but is not due to the local presence of cancer cells. These phenomena are mediated by [[humoral]] factors (by [[Hormone|hormones]] or [[Cytokine|cytokines]]) excreted by [[tumor]] cells or by an [[immune response]] against the [[tumor]]. Sometimes the [[symptoms]] of paraneoplastic syndromes show even before the [[diagnosis]] of a [[Malignant|malignancy]]. A paraneoplastic syndrome is a set of symptoms that are caused by a [[cancer]]. The symptoms happen in a different area of your [[body]] from your [[cancer]]. | A '''paraneoplastic syndrome''' is a [[disease]] or [[symptom]] that is the consequence of the presence of [[cancer]] in the body, but is not due to the local presence of [[cancer]] cells. These phenomena are mediated by [[humoral]] factors (by [[Hormone|hormones]] or [[Cytokine|cytokines]]) excreted by [[tumor]] cells or by an [[immune response]] against the [[tumor]]. Sometimes the [[symptoms]] of paraneoplastic syndromes show even before the [[diagnosis]] of a [[Malignant|malignancy]]. A paraneoplastic syndrome is a set of [[symptoms]] that are caused by a [[cancer]]. The symptoms happen in a different area of your [[body]] from your [[cancer]]. | ||
==Causes== | ==Causes== | ||
*Paraneoplastic syndromes are caused by your [[cancer]] making [[hormones]] or your [[immune]] system making [[antibodies]] (substances that protect your body against certain [[infection]]) that flow through your [[blood]] | *Paraneoplastic syndromes are caused by your [[cancer]] making [[hormones]] or your [[immune]] system making [[antibodies]] (substances that protect your body against certain [[infection]]) that flow through your [[blood]] | ||
*Paraneoplastic syndromes cause different symptoms depending on the [[tissues]] and [[organs]] they are involved. | *Paraneoplastic syndromes cause different [[symptoms]] depending on the [[tissues]] and [[organs]] they are involved. | ||
*About 20% of people with [[cancer]] get a paraneoplastic syndrome and the most common [[cancers]] are [[lung]], [[Hepatocellular carcinoma|hepatocellular]], [[ovarian]], [[breast]], [[gastric]] , [[pancreatic]] and other [[cancers]]. | *About 20% of people with [[cancer]] get a paraneoplastic syndrome and the most common [[cancers]] are [[lung]], [[Hepatocellular carcinoma|hepatocellular]], [[ovarian]], [[breast]], [[gastric]] , [[pancreatic]] and other [[cancers]]. | ||
==What are the symptoms of paraneoplastic syndromes?== | ==What are the symptoms of paraneoplastic syndromes?== | ||
===General symptoms=== | ===General symptoms=== | ||
*Fever | *[[Fever]] | ||
*Night sweats | *[[Night sweats]] | ||
*Loss of appetite | *[[Loss of appetite]] | ||
*[[Weight loss]] | |||
===Skin symptoms=== | ===Skin symptoms=== | ||
*Itching | *[[Itching]] | ||
*Skin flushing or blushing, causing your face, neck, or upper chest to become warm and red | *[[Skin]] flushing or blushing, causing your face, neck, or upper [[chest]] to become warm and red. | ||
===Neurologic (brain, spinal cord, and nerve) symptoms=== | ===Neurologic (brain, spinal cord, and nerve) symptoms=== | ||
*Weakness or loss of strength | *[[Weakness]] or loss of strength | ||
*Loss of feeling | *[[Numbness|Loss of feeling]] | ||
*Slower reflexes | *Slower reflexes | ||
*Trouble using different parts of your body the way you want, such as your arms or legs | *Trouble using different parts of your body the way you want, such as your arms or legs | ||
*Trouble speaking | *[[Trouble|Trouble speaking]] | ||
*Dizziness | *[[Dizziness]] | ||
*Double vision (when you see | *[[Double vision]] (when you see two of the same object) or being unable to control your [[eye]] movements | ||
The cancer can cause these symptoms without pushing on your nerves or spinal cord | The [[cancer]] can cause these [[symptoms]] without pushing on your [[nerves]] or [[spinal cord]]. | ||
===Endocrine (hormone system) symptoms=== | ===Endocrine (hormone system) symptoms=== | ||
Revision as of 16:03, 14 August 2019
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Paraneoplastic syndrome |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2]
Overview
A paraneoplastic syndrome is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. These phenomena are mediated by humoral factors (by hormones or cytokines) excreted by tumor cells or by an immune response against the tumor. Sometimes the symptoms of paraneoplastic syndromes show even before the diagnosis of a malignancy. A paraneoplastic syndrome is a set of symptoms that are caused by a cancer. The symptoms happen in a different area of your body from your cancer.
Causes
- Paraneoplastic syndromes are caused by your cancer making hormones or your immune system making antibodies (substances that protect your body against certain infection) that flow through your blood
- Paraneoplastic syndromes cause different symptoms depending on the tissues and organs they are involved.
- About 20% of people with cancer get a paraneoplastic syndrome and the most common cancers are lung, hepatocellular, ovarian, breast, gastric , pancreatic and other cancers.
What are the symptoms of paraneoplastic syndromes?
General symptoms
Skin symptoms
Neurologic (brain, spinal cord, and nerve) symptoms
- Weakness or loss of strength
- Loss of feeling
- Slower reflexes
- Trouble using different parts of your body the way you want, such as your arms or legs
- Double vision (when you see two of the same object) or being unable to control your eye movements
The cancer can cause these symptoms without pushing on your nerves or spinal cord.
Endocrine (hormone system) symptoms
- Weakness
- Weight gain
- High blood pressure or heart valve problems
- Confusion
- Kidney problems
- Red, warm skin
- Wheezing
- Diarrhea
Other symptoms
- Muscle swelling that causes weakness and soreness
- Painful swelling of your joints that may change the shape of your fingers and toes
- Changes to your blood cells (red blood cells, white blood cells, and platelets)
Prognosis
- There are no cures for paraneoplastic syndromes. The type and stage of the diagnosis of the cancer determine the prognosis.
Treatment
- The tumor and cancer are treated first, followed by efforts to decrease the autoimmune response, either through steroids such as cortisone or prednisone, high-dose intravenous immunoglobulin, or irradiation.
- Plasmapheresis, a process that cleanses antibodies from the blood, may ease symptoms in people with paraneoplastic disorders that affect the peripheral nervous system.
- Speech and physical therapy may help individuals regain some functions.