Paraneoplastic syndrome: Difference between revisions
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**[[Granulocytosis]] (increased [[granulocyte]]s) due to the production of [[Granulocyte colony-stimulating factor|G-CSF]] | **[[Granulocytosis]] (increased [[granulocyte]]s) due to the production of [[Granulocyte colony-stimulating factor|G-CSF]] | ||
*Endocrine metabolic syndromes<ref>{{MeshName|Paraneoplastic+endocrine+syndromes}}</ref> | *Endocrine metabolic syndromes<ref>{{MeshName|Paraneoplastic+endocrine+syndromes}}</ref><ref name="pmid15673803">{{cite journal |vauthors=Stewart AF |title=Clinical practice. Hypercalcemia associated with cancer |journal=N. Engl. J. Med. |volume=352 |issue=4 |pages=373–9 |date=January 2005 |pmid=15673803 |doi=10.1056/NEJMcp042806 |url=}}</ref><ref name="pmid16337807">{{cite journal |vauthors=Spinazzé S, Schrijvers D |title=Metabolic emergencies |journal=Crit. Rev. Oncol. Hematol. |volume=58 |issue=1 |pages=79–89 |date=April 2006 |pmid=16337807 |doi=10.1016/j.critrevonc.2005.04.004 |url=}}</ref> | ||
**[[Hypercalcemia]] in [[breast cancer]] and [[lung cancer]] (typically squamous cell) due to the production of [[Parathyroid hormone-related protein|PTHrP]] (Parathyroid hormone-related protein) | **[[Hypercalcemia]] in [[breast cancer]] and [[lung cancer]] (typically squamous cell) due to the production of [[Parathyroid hormone-related protein|PTHrP]] (Parathyroid hormone-related protein) | ||
**[[Syndrome of inappropriate antidiuretic hormone|SIADH]] associated | ***Seen in multiple myeloma, renal cell carcinoma, ovarian cancer, endometrial cancer, and lymphoma | ||
**[[Syndrome of inappropriate antidiuretic hormone|SIADH]] associated with lung and CNS malignancies, typically [[Small cell carcinoma|small cell]]. | |||
**Ectopic [[ACTH]] secretion associated with [[Small cell carcinoma|small-cell lung cancer]], [[carcinoid tumor]], [[thymoma]] and other cancers | **Ectopic [[ACTH]] secretion associated with [[Small cell carcinoma|small-cell lung cancer]], [[carcinoid tumor]], [[thymoma]] and other cancers | ||
**[[Tumor induced osteomalacia]] | **[[Tumor induced osteomalacia]] | ||
Revision as of 15:44, 4 June 2019
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Paraneoplastic syndrome Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2]
Synonyms and keywords: Paraneoplastic syndrome
Overview
A paraneoplastic syndrome is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. These phenomena are mediated by humoral factors (by hormones or cytokines) excreted by tumor cells or by an immune response against the tumor. Sometimes the symptoms of paraneoplastic syndromes show even before the diagnosis of a malignancy.
Classification
Paraneoplastic syndromes can be divided into 4 main categories:
- Mucocutaneous paraneoplastic syndromes [1]
- Dermatomyositis (25-50% of adult patients have an underlying malignancy)
- Leser-Trélat sign, a sudden onset of many pigmented skin lesions
- Acanthosis nigricans
- Necrolytic migratory erythema
- Sweet's syndrome
- Pyoderma gangrenosum
- Neurological paraneoplastic syndromes [2]
- Paraneoplastic cerebellar degeneration associated with lung, ovarian, breast, lymphatic, and other cancers
- Encephalomyelitis (inflammation of the brain and spinal cord)
- Limbic encephalitis
- Brainstem encephalitis
- Opsoclonus (involving eye movement)
- Encephalitis triggered by a teratoma[3]
- Polymyositis
- Lambert-Eaton myasthenic syndrome (LEMS) in small-cell lung cancer
- Hematological paraneoplastic syndromes [4]
- Granulocytosis (increased granulocytes) due to the production of G-CSF
- Endocrine metabolic syndromes[5][6][7]
- Hypercalcemia in breast cancer and lung cancer (typically squamous cell) due to the production of PTHrP (Parathyroid hormone-related protein)
- Seen in multiple myeloma, renal cell carcinoma, ovarian cancer, endometrial cancer, and lymphoma
- SIADH associated with lung and CNS malignancies, typically small cell.
- Ectopic ACTH secretion associated with small-cell lung cancer, carcinoid tumor, thymoma and other cancers
- Tumor induced osteomalacia
- Hypercalcemia in breast cancer and lung cancer (typically squamous cell) due to the production of PTHrP (Parathyroid hormone-related protein)
- Others that may not fit into any of the above categories include:
Causes
Differential diagnosis
References
- ↑ Cohen PR, Kurzrock R (1997). "Mucocutaneous paraneoplastic syndromes". Semin. Oncol. 24 (3): 334–59. PMID 9208889.
- ↑ Nervous+system+paraneoplastic+syndromes at the US National Library of Medicine Medical Subject Headings (MeSH)
- ↑ Dalmau J, Tüzün E, Wu HY; et al. (2007). "Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma". Ann. Neurol. 61 (1): 25–36. doi:10.1002/ana.21050. PMC 2430743. PMID 17262855. Unknown parameter
|month=ignored (help) - ↑ Staszewski H (1997). "Hematological paraneoplastic syndromes". Semin. Oncol. 24 (3): 329–33. PMID 9208888.
- ↑ Paraneoplastic+endocrine+syndromes at the US National Library of Medicine Medical Subject Headings (MeSH)
- ↑ Stewart AF (January 2005). "Clinical practice. Hypercalcemia associated with cancer". N. Engl. J. Med. 352 (4): 373–9. doi:10.1056/NEJMcp042806. PMID 15673803.
- ↑ Spinazzé S, Schrijvers D (April 2006). "Metabolic emergencies". Crit. Rev. Oncol. Hematol. 58 (1): 79–89. doi:10.1016/j.critrevonc.2005.04.004. PMID 16337807.