Paraganglioma causes: Difference between revisions

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Revision as of 15:36, 28 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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 ==Overview==
 ==Causes==
-Familial paragangliomas account for approx. 25% of cases, are often multiple and bilateral, and occur at an earlier age.  Mutations of the genes [[SDHD]] (previously known as PGL1), [[PGL2]], and [[SDHC (gene)|SDHC]] (previously PGL3) have been identified as causing familial head and neck paragangliomas. Mutations of [[SDHB]] play an important role in familial adrenal pheochromocytoma and extra-adrenal paraganglioma (of abdomen and thorax), although there is considerable overlap in the types of tumors associated with SDHB and SDHD gene mutations.
 ==References==
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