Pancreatic cancer causes
|
Pancreatic cancer Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Pancreatic cancer causes On the Web |
|
American Roentgen Ray Society Images of Pancreatic cancer causes |
|
Risk calculators and risk factors for Pancreatic cancer causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Pancreatic cancer may be caused by the inactivation of tumor suppressor genes such as p53, p16, p27CIP1 and BRCA2. Oncogenes such as Ras , Cox-2, Akt-2, Notch and Cyclin D1 may undergo activation and lead to the development of pancreatic cancer. Deregulation and crosstalk between different signal transduction pathways due to genomic alterations also have a proven role in the causation of pancreatic cancer.
Causes
- Pancreatic cancer may be caused by the following:[1][2][3]
- Inactivation of tumor suppressor genes
- Activation of oncogenes
- Deregulation of molecules in various signaling pathways
- Inactivation of tumor suppressor genes:
- Tumor suppressor genes may be inactivated by:
- Tumor suppressor genes:
- Deregulation of molecules in various signaling pathways:
References
- ↑ Yabar CS, Winter JM (2016). "Pancreatic Cancer: A Review". Gastroenterol Clin North Am. 45 (3): 429–45. doi:10.1016/j.gtc.2016.04.003. PMID 27546841.
- ↑ Ryan DP, Hong TS, Bardeesy N (2014). "Pancreatic adenocarcinoma". N Engl J Med. 371 (11): 1039–49. doi:10.1056/NEJMra1404198. PMID 25207767.
- ↑ Goral V (2015). "Pancreatic Cancer: Pathogenesis and Diagnosis". Asian Pac J Cancer Prev. 16 (14): 5619–24. PMID 26320426.