Pancreatic cancer causes: Difference between revisions
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==Causes== | ==Causes== | ||
*Pancreatic cancer may be caused by the following: | *Pancreatic cancer may be caused by the following: <ref name="pmid27546841">{{cite journal| author=Yabar CS, Winter JM| title=Pancreatic Cancer: A Review. | journal=Gastroenterol Clin North Am | year= 2016 | volume= 45 | issue= 3 | pages= 429-45 | pmid=27546841 | doi=10.1016/j.gtc.2016.04.003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27546841 }} </ref> <ref name="pmid25207767">{{cite journal| author=Ryan DP, Hong TS, Bardeesy N| title=Pancreatic adenocarcinoma. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 11 | pages= 1039-49 | pmid=25207767 | doi=10.1056/NEJMra1404198 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25207767 }} </ref> <ref name="pmid26320426">{{cite journal| author=Goral V| title=Pancreatic Cancer: Pathogenesis and Diagnosis. | journal=Asian Pac J Cancer Prev | year= 2015 | volume= 16 | issue= 14 | pages= 5619-24 | pmid=26320426 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26320426 }} </ref> | ||
**'''Inactivation of [[Tumor suppressor gene|tumor suppressor genes]]''' | **'''Inactivation of [[Tumor suppressor gene|tumor suppressor genes]]''' | ||
**'''Activation of [[Oncogene|oncogenes]]''' | **'''Activation of [[Oncogene|oncogenes]]''' |
Revision as of 21:28, 14 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Causes
- Pancreatic cancer may be caused by the following: [1] [2] [3]
- Inactivation of tumor suppressor genes
- Activation of oncogenes
- Deregulation of molecules in various signaling pathways
- Inactivation of tumor suppressor genes:
- Tumor suppressor genes may be inactivated by:
- Tumor suppressor genes:
- p53
- p16
- p27CIP1
- BRCA2
- Activation of oncogenes
- Oncogenes may be activated by:
- Oncogenes:
- Ras oncogene
- Cox-2 activation
- Akt-2 gene amplification
- Notch gene
- Cyclin D1
- Deregulation of molecules in various signaling pathways
References
- ↑ Yabar CS, Winter JM (2016). "Pancreatic Cancer: A Review". Gastroenterol Clin North Am. 45 (3): 429–45. doi:10.1016/j.gtc.2016.04.003. PMID 27546841.
- ↑ Ryan DP, Hong TS, Bardeesy N (2014). "Pancreatic adenocarcinoma". N Engl J Med. 371 (11): 1039–49. doi:10.1056/NEJMra1404198. PMID 25207767.
- ↑ Goral V (2015). "Pancreatic Cancer: Pathogenesis and Diagnosis". Asian Pac J Cancer Prev. 16 (14): 5619–24. PMID 26320426.