Pancreatic cancer causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
Line 10: | Line 10: | ||
**Activation of [[Oncogene|oncogenes]] | **Activation of [[Oncogene|oncogenes]] | ||
**Deregulation of molecules in various [[Signal transduction|signaling pathways]] | **Deregulation of molecules in various [[Signal transduction|signaling pathways]] | ||
<br/> | <br/> | ||
*'''Inactivation of tumor suppressor genes:''' | *'''Inactivation of tumor suppressor genes:''' | ||
Line 22: | Line 21: | ||
***'''p27CIP1''' | ***'''p27CIP1''' | ||
***'''BRCA2''' | ***'''BRCA2''' | ||
*Activation of [[Oncogene|oncogenes]] | *Activation of [[Oncogene|oncogenes]] | ||
**Oncogenes may be activated by: | **Oncogenes may be activated by: | ||
Line 33: | Line 32: | ||
***'''Notch gene''' | ***'''Notch gene''' | ||
***'''cyclin D1''' | ***'''cyclin D1''' | ||
*Deregulation of molecules in various [[Signal transduction|signaling pathways]]: | *Deregulation of molecules in various [[Signal transduction|signaling pathways]]: | ||
**Genomic alterations of [[EGFR]] include the following: | **Genomic alterations of [[EGFR]] include the following: | ||
Line 43: | Line 42: | ||
**'''Deregulation of Akt signaling''' | **'''Deregulation of Akt signaling''' | ||
**'''Deregulation of Hedgehog signaling''' | **'''Deregulation of Hedgehog signaling''' | ||
==References== | ==References== |
Revision as of 21:21, 14 November 2017
Pancreatic cancer Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Pancreatic cancer causes On the Web |
American Roentgen Ray Society Images of Pancreatic cancer causes |
Risk calculators and risk factors for Pancreatic cancer causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Causes
- Pancreatic cancer may be caused by the following:
- Inactivation of tumor suppressor genes
- Activation of oncogenes
- Deregulation of molecules in various signaling pathways
- Inactivation of tumor suppressor genes:
- Tumor suppressor genes may be inactivated by:
- Tumor suppressor genes:
- p53
- p16
- p27CIP1
- BRCA2
- Activation of oncogenes
- Oncogenes may be activated by:
- Oncogenes:
- Ras oncogene
- Cox-2 activation
- Akt-2 gene amplification
- Notch gene
- cyclin D1
- Deregulation of molecules in various signaling pathways: