PYCR1

Pyrroline-5-carboxylate reductase 1
File:PBB Protein PYCR1 image.jpg PDB rendering based on 2ger.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ger​, 2gr9​, 2gra​, 2izz​
Identifiers
Symbols	PYCR1 ; P5C; P5CR; PIG45; PP222; PYCR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56002
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PYCR1 202148 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Pyrroline-5-carboxylate reductase 1, also known as PYCR1, is a human gene.

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.

Further reading

• Herzfeld A, Legg MA, Greengard O (1978). "Human colon tumors: enzymic and histological characteristics". Cancer. 42 (3): 1280–3. PMID 212173.CS1 maint: Multiple names: authors list (link)
• Dougherty KM, Brandriss MC, Valle D (1992). "Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae". J. Biol. Chem. 267 (2): 871–5. PMID 1730675.CS1 maint: Multiple names: authors list (link)
• Merrill MJ, Yeh GC, Phang JM (1989). "Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH". J. Biol. Chem. 264 (16): 9352–8. PMID 2722838.CS1 maint: Multiple names: authors list (link)
• Yeh GC, Roth EF, Phang JM; et al. (1984). "The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects". J. Biol. Chem. 259 (9): 5454–8. PMID 6201483.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herzfeld A, Greengard O (1981). "Enzyme activities in human fetal and neoplastic tissues". Cancer. 46 (9): 2047–54. PMID 6253048.
• Yeh GC, Harris SC, Phang JM (1981). "Pyrroline-5-carboxylate reductase in human erythrocytes". J. Clin. Invest. 67 (4): 1042–6. PMID 6894153.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Basch JJ, Wickham ED, Farrell HM (1997). "Pyrroline-5-carboxylate reductase in lactating bovine mammary glands". J. Dairy Sci. 79 (8): 1361–8. PMID 8880459.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meng Z, Lou Z, Liu Z; et al. (2006). "Crystal structure of human pyrroline-5-carboxylate reductase". J. Mol. Biol. 359 (5): 1364–77. doi:10.1016/j.jmb.2006.04.053. PMID 16730026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)