PTPRU

Protein tyrosine phosphatase, receptor type, U
Identifiers
Symbols	PTPRU ; PTPRO; GLEPP1; PTPU2; PTP; FLJ37530; FMI; PCP-2; PTP-J; PTP-PI; PTPPSI; R-PTP-PSI; hPTP-J
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4168
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PTPRU 211320 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, receptor type, U, also known as PTPRU, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Three alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Further reading

• Wang H, Lian Z, Lerch MM; et al. (1996). "Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family". Oncogene. 12 (12): 2555–62. PMID 8700514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Crossland S, Smith PD, Crompton MR (1996). "Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase". Biochem. J. 319 ( Pt 1): 249–54. PMID 8870675.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Wang B, Kishihara K, Zhang D; et al. (1997). "Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells". Biochem. Biophys. Res. Commun. 231 (1): 77–81. doi:10.1006/bbrc.1997.6004. PMID 9070223.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin BZ, Pilch PF, Kandror KV (1997). "Sortilin is a major protein component of Glut4-containing vesicles". J. Biol. Chem. 272 (39): 24145–7. PMID 9305862.CS1 maint: Multiple names: authors list (link)
• Avraham S, London R, Tulloch GA; et al. (1998). "Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells". Gene. 204 (1–2): 5–16. PMID 9434160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Serra-Pagès C, Medley QG, Tang M; et al. (1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. PMID 9624153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo Y, Denker BM (1999). "Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor". J. Biol. Chem. 274 (16): 10685–8. PMID 10196137.
• Wang B, Kishihara K, Zhang D; et al. (1999). "Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells". Biochim. Biophys. Acta. 1450 (3): 331–40. PMID 10395944.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taniguchi Y, London R, Schinkmann K; et al. (1999). "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor". Blood. 94 (2): 539–49. PMID 10397721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan HX, He YQ, Dong H; et al. (2003). "Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin". Biochemistry. 41 (52): 15854–60. PMID 12501215.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Amoui M, Baylink DJ, Tillman JB, Lau KH (2004). "Expression of a structurally unique osteoclastic protein-tyrosine phosphatase is driven by an alternative intronic, cell type-specific promoter". J. Biol. Chem. 278 (45): 44273–80. doi:10.1074/jbc.M303933200. PMID 12949066.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Willard FS, McCudden CR, Siderovski DP (2006). "G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2)". Cell. Signal. 18 (8): 1226–34. doi:10.1016/j.cellsig.2005.10.003. PMID 16298104.CS1 maint: Multiple names: authors list (link)
• Hirakawa M, Tsuruya K, Yotsueda H; et al. (2006). "Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis". Life Sci. 79 (8): 757–63. doi:10.1016/j.lfs.2006.02.031. PMID 16564554.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan HX, Yang W, Zhang R; et al. (2006). "Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion". J. Biol. Chem. 281 (22): 15423–33. doi:10.1074/jbc.M602607200. PMID 16574648.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)