PTPRS

Protein tyrosine phosphatase, receptor type, S
File:PBB Protein PTPRS image.jpg PDB rendering based on 2fh7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2fh7​
Identifiers
Symbols	PTPRS ; PTPSIGMA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20626
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PTPRS 210823 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, receptor type, S, also known as PTPRS, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Further reading

• Adachi M, Sekiya M, Arimura Y; et al. (1992). "Protein-tyrosine phosphatase expression in pre-B cell NALM-6". Cancer Res. 52 (3): 737–40. PMID 1370651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pulido R, Serra-Pagès C, Tang M, Streuli M (1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. PMID 8524829.CS1 maint: Multiple names: authors list (link)
• Wagner J, Gordon LA, Heng HH; et al. (1997). "Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3". Genomics. 38 (1): 76–8. doi:10.1006/geno.1996.0594. PMID 8954782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Endo N, Rutledge SJ, Opas EE; et al. (1997). "Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates". J. Bone Miner. Res. 11 (4): 535–43. PMID 8992885.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Norris K, Norris F, Kono DH; et al. (1997). "Expression of protein-tyrosine phosphatases in the major insulin target tissues". FEBS Lett. 415 (3): 243–8. PMID 9357975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wallace MJ, Fladd C, Batt J, Rotin D (1998). "The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma". Mol. Cell. Biol. 18 (5): 2608–16. PMID 9566880.CS1 maint: Multiple names: authors list (link)
• Serra-Pagès C, Medley QG, Tang M; et al. (1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. PMID 9624153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haworth K, Shu KK, Stokes A; et al. (1998). "The expression of receptor tyrosine phosphatases is responsive to sciatic nerve crush". Mol. Cell. Neurosci. 12 (3): 93–104. doi:10.1006/mcne.1998.0707. PMID 9790732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elchebly M, Wagner J, Kennedy TE; et al. (1999). "Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma". Nat. Genet. 21 (3): 330–3. doi:10.1038/6859. PMID 10080191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wallace MJ, Batt J, Fladd CA; et al. (1999). "Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma". Nat. Genet. 21 (3): 334–8. doi:10.1038/6866. PMID 10080192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suárez Pestana E, Tenev T, Gross S; et al. (1999). "The transmembrane protein tyrosine phosphatase RPTPsigma modulates signaling of the epidermal growth factor receptor in A431 cells". Oncogene. 18 (28): 4069–79. doi:10.1038/sj.onc.1202794. PMID 10435588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J (2003). "Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases". J. Biol. Chem. 277 (49): 47263–9. doi:10.1074/jbc.M205810200. PMID 12376545.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu YF, Zhang HL, Cai T; et al. (2006). "The IA-2 interactome". Diabetologia. 48 (12): 2576–81. doi:10.1007/s00125-005-0037-y. PMID 16273344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lajus S, Lang J (2006). "Splice variant 3, but not 2 of receptor protein-tyrosine phosphatase sigma can mediate stimulation of insulin-secretion by alpha-latrotoxin". J. Cell. Biochem. 98 (6): 1552–9. doi:10.1002/jcb.20871. PMID 16552719.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)