PTPRJ

Protein tyrosine phosphatase, receptor type, J
File:PBB Protein PTPRJ image.jpg PDB rendering based on 2cfv.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2cfv​, 2dle​, 2nz6​
Identifiers
Symbols	PTPRJ ; CD148; DEP1; HPTPeta; R-PTP-ETA; SCC1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2130
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PTPRJ 210173 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, receptor type, J, also known as PTPRJ, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.

Further reading

• Harrod TR, Justement LB (2003). "Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology". Immunol. Res. 26 (1–3): 153–66. PMID 12403354.
• Ostman A, Yang Q, Tonks NK (1994). "Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density". Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9680–4. PMID 7937872.CS1 maint: Multiple names: authors list (link)
• Honda H, Inazawa J, Nishida J; et al. (1995). "Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta". Blood. 84 (12): 4186–94. PMID 7994032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jallal B, Mossie K, Vasiloudis G; et al. (1997). "The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase". J. Biol. Chem. 272 (18): 12158–63. PMID 9115287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de la Fuente-García MA, Nicolás JM, Freed JH; et al. (1998). "CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes". Blood. 91 (8): 2800–9. PMID 9531590.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tangye SG, Phillips JH, Lanier LL; et al. (1998). "CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation". J. Immunol. 161 (7): 3249–55. PMID 9759839.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gross S, Knebel A, Tenev T; et al. (1999). "Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction". J. Biol. Chem. 274 (37): 26378–86. PMID 10473595.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Autschbach F, Palou E, Mechtersheimer G; et al. (2000). "Expression of the membrane protein tyrosine phosphatase CD148 in human tissues". Tissue Antigens. 54 (5): 485–98. PMID 10599888.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Billard C, Delaire S, Raffoux E; et al. (2000). "Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage". Blood. 95 (3): 965–72. PMID 10648410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kovalenko M, Denner K, Sandström J; et al. (2000). "Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1". J. Biol. Chem. 275 (21): 16219–26. PMID 10821867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• del Pozo V, Pirotto F, Cárdaba B; et al. (2000). "Expression on human eosinophils of CD148: a membrane tyrosine phosphatase. Implications in the effector function of eosinophils". J. Leukoc. Biol. 68 (1): 31–7. PMID 10914487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baker JE, Majeti R, Tangye SG, Weiss A (2001). "Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation". Mol. Cell. Biol. 21 (7): 2393–403. doi:10.1128/MCB.21.7.2393-2403.2001. PMID 11259588.CS1 maint: Multiple names: authors list (link)
• Persson C, Engström U, Mowbray SL, Ostman A (2002). "Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1". FEBS Lett. 517 (1–3): 27–31. PMID 12062403.CS1 maint: Multiple names: authors list (link)
• Ruivenkamp CA, van Wezel T, Zanon C; et al. (2002). "Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers". Nat. Genet. 31 (3): 295–300. doi:10.1038/ng903. PMID 12089527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holsinger LJ, Ward K, Duffield B; et al. (2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene. 21 (46): 7067–76. doi:10.1038/sj.onc.1205858. PMID 12370829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dong HY, Shahsafaei A, Dorfman DM (2003). "CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells". Leuk. Lymphoma. 43 (9): 1855–8. PMID 12685844.CS1 maint: Multiple names: authors list (link)
• Kellie S, Craggs G, Bird IN, Jones GE (2004). "The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation". J. Cell. Sci. 117 (Pt 4): 609–18. doi:10.1242/jcs.00879. PMID 14709717.CS1 maint: Multiple names: authors list (link)
• Massa A, Barbieri F, Aiello C; et al. (2004). "The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation". J. Biol. Chem. 279 (28): 29004–12. doi:10.1074/jbc.M403573200. PMID 15123617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)