PTPN14

Protein tyrosine phosphatase, non-receptor type 14
File:PBB Protein PTPN14 image.jpg PDB rendering based on 2bzl.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2bzl​
Identifiers
Symbols	PTPN14 ; MGC126803; PEZ; PTP36
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3941
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PTPN14 205503 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, non-receptor type 14, also known as PTPN14, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.

Further reading

• Gyapay G, Morissette J, Vignal A; et al. (1994). "The 1993-94 Généthon human genetic linkage map". Nat. Genet. 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID 7545953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith AL, Mitchell PJ, Shipley J; et al. (1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochem. Biophys. Res. Commun. 209 (3): 959–65. doi:10.1006/bbrc.1995.1591. PMID 7733990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogata M, Takada T, Mori Y; et al. (1999). "Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells". J. Biol. Chem. 274 (18): 12905–9. PMID 10212280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogata M, Takada T, Mori Y; et al. (1999). "Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion". J. Biol. Chem. 274 (29): 20717–24. PMID 10400706.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aoyama K, Matsuda T, Aoki N (2000). "Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36". Biochem. Biophys. Res. Commun. 266 (2): 523–31. doi:10.1006/bbrc.1999.1845. PMID 10600535.CS1 maint: Multiple names: authors list (link)
• Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (2000). "Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation". J. Cell. Sci. 113 ( Pt 17): 3117–23. PMID 10934049.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (2004). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Mol. Biol. Cell. 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMID 12808048.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barr AJ, Debreczeni JE, Eswaran J, Knapp S (2006). "Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution". Proteins. 63 (4): 1132–6. doi:10.1002/prot.20958. PMID 16534812.CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)