https://www.wikidoc.org/index.php?title=PRRX2&feed=atom&action=historyPRRX2 - Revision history2024-03-29T09:29:57ZRevision history for this page on the wikiMediaWiki 1.40.0https://www.wikidoc.org/index.php?title=PRRX2&diff=1422822&oldid=preven>KolbertBot: Bot: HTTP→HTTPS2017-09-07T18:46:41Z<p>Bot: <a href="/index.php?title=User:KolbertBot&action=edit&redlink=1" class="new" title="User:KolbertBot (page does not exist)">HTTP→HTTPS</a></p>
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'''Paired mesoderm homeobox protein 2''' is a [[protein]] that in humans is encoded by the ''PRRX2'' [[gene]].<ref name="pmid11063257">{{cite journal | vauthors = Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ | title = Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome | journal = Mamm Genome | volume = 11 | issue = 11 | pages = 1000–5 |date=Mar 2001 | pmid = 11063257 | pmc = | doi =10.1007/s003350010193 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRRX2 paired related homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51450| accessdate = }}</ref><br />
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== Function ==<br />
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The DNA-associated protein encoded by this gene is a member of the paired family of [[homeobox]] proteins. Expression is localized to proliferating fetal [[fibroblast]]s and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.<ref name="entrez" /><br />
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==References==<br />
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==Further reading==<br />
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*{{cite journal |vauthors=Tokutomi Y, Araki N, Kataoka K, etal |title=Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis. |journal=Biochem. Biophys. Res. Commun. |volume=364 |issue= 4 |pages= 822–30 |year= 2007 |pmid= 17964282 |doi= 10.1016/j.bbrc.2007.10.095 }}<br />
*{{cite journal |vauthors=Wissmüller S, Kosian T, Wolf M, etal |title=The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1735–44 |year= 2006 |pmid= 16582099 |doi= 10.1093/nar/gkl105 | pmc=1421504 }}<br />
*{{cite journal |vauthors=Gervais C, Mauvieux L, Perrusson N, etal |title=A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. |journal=Leukemia |volume=19 |issue= 1 |pages= 145–8 |year= 2005 |pmid= 15496970 |doi= 10.1038/sj.leu.2403565 }}<br />
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}<br />
*{{cite journal |vauthors=Scott KK, Norris RA, Potter SS, etal |title=GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. |journal=DNA Cell Biol. |volume=22 |issue= 2 |pages= 95–105 |year= 2003 |pmid= 12713735 |doi= 10.1089/104454903321515904 }}<br />
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}<br />
*{{cite journal |vauthors=Jones FS, McKean DM, Meech R, etal |title=Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes. |journal=Chest |volume=121 |issue= 3 Suppl |pages= 89S–90S |year= 2002 |pmid= 11893718 |doi=10.1378/chest.121.3_suppl.89S-a }}<br />
*{{cite journal |vauthors=Stelnicki EJ, Arbeit J, Cass DL, etal |title=Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. |journal=J. Invest. Dermatol. |volume=111 |issue= 1 |pages= 57–63 |year= 1998 |pmid= 9665387 |doi= 10.1046/j.1523-1747.1998.00238.x }}<br />
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{{Transcription factors|g3}}<br />
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[[Category:Transcription factors]]<br />
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