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Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6gene.[1][2][3]
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.[3]
↑Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors". Biochim Biophys Acta. 1435 (1–2): 147–52. doi:10.1016/s0167-4838(99)00203-4. PMID10561546.
↑Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". J Mol Biol. 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID10788320.
↑Sun, Xiaojing; Zhang Hua; Wang Dan; Ma Dalong; Shen Yan; Shang Yongfeng (July 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. United States. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. ISSN0021-9258. PMID15161931.
↑Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. United States. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN0888-7543. PMID12620389.
↑Zhao, Yue; Goto Kiminobu; Saitoh Masayuki; Yanase Toshihiko; Nomura Masatoshi; Okabe Taijiro; Takayanagi Ryoichi; Nawata Hajime (August 2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. United States. 277 (33): 30031–9. doi:10.1074/jbc.M203811200. ISSN0021-9258. PMID12039962.
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Zhao Y, Goto K, Saitoh M, et al. (2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. 277 (33): 30031–9. doi:10.1074/jbc.M203811200. PMID12039962.
Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID12620389.
Goto K, Zhao Y, Saito M, et al. (2003). "Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments". J. Steroid Biochem. Mol. Biol. 85 (2–5): 201–8. doi:10.1016/S0960-0760(03)00196-1. PMID12943705.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Sun X, Zhang H, Wang D, et al. (2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. PMID15161931.
Batsché E, Yaniv M, Muchardt C (2006). "The human SWI/SNF subunit Brm is a regulator of alternative splicing". Nat. Struct. Mol. Biol. 13 (1): 22–9. doi:10.1038/nsmb1030. PMID16341228.
Fan S, Goto K, Chen G, et al. (2006). "Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor". Biochem. Biophys. Res. Commun. 341 (1): 192–201. doi:10.1016/j.bbrc.2005.12.167. PMID16414017.
