PRKCI

Protein kinase C, iota
File:PBB Protein PRKCI image.jpg PDB rendering based on 1vd2.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1vd2​, 1wmh​, 1zrz​
Identifiers
Symbols	PRKCI ; DXS1179E; MGC26534; PKCI; nPKC-iota
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37667
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PRKCI 209678 s at tn.png
File:PBB GE PRKCI 209677 at tn.png
File:PBB GE PRKCI 213518 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein kinase C, iota, also known as PRKCI, is a human gene.

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Further reading

• Suzuki A, Akimoto K, Ohno S (2003). "Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms". J. Biochem. 133 (1): 9–16. PMID 12761193.CS1 maint: Multiple names: authors list (link)
• Fields AP, Regala RP (2007). "Protein kinase C iota: human oncogene, prognostic marker and therapeutic target". Pharmacol. Res. 55 (6): 487–97. doi:10.1016/j.phrs.2007.04.015. PMID 17570678.
• Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1): 1–13. PMID 1832084.
• Chowdhury IH, Koyanagi Y, Kobayashi S; et al. (1990). "The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway". Virology. 176 (1): 126–32. PMID 1970444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruegg CL, Strand M (1990). "Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41". J. Immunol. 144 (10): 3928–35. PMID 2139676.
• Jakobovits A, Rosenthal A, Capon DJ (1990). "Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.". EMBO J. 9 (4): 1165–70. PMID 2182321.CS1 maint: Multiple names: authors list (link)
• Fields AP, Bednarik DP, Hess A, May WS (1988). "Human immunodeficiency virus induces phosphorylation of its cell surface receptor". Nature. 333 (6170): 278–80. doi:10.1038/333278a0. PMID 3259291.CS1 maint: Multiple names: authors list (link)
• Mazzarella R, Ciccodicola A, Esposito T; et al. (1995). "Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3". Genomics. 26 (3): 629–31. PMID 7607695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chirmule N, Goonewardena H, Pahwa S; et al. (1995). "HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells". J. Biol. Chem. 270 (33): 19364–9. PMID 7642615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ward NE, Gravitt KR, O'Brian CA (1995). "Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein". Cancer Lett. 88 (1): 37–40. PMID 7850771.CS1 maint: Multiple names: authors list (link)
• Gupta S, Aggarwal S, Kim C, Gollapudi S (1994). "Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report". Int. J. Immunopharmacol. 16 (3): 197–204. PMID 8206685.CS1 maint: Multiple names: authors list (link)
• Selbie LA, Schmitz-Peiffer C, Sheng Y, Biden TJ (1993). "Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells". J. Biol. Chem. 268 (32): 24296–302. PMID 8226978.CS1 maint: Multiple names: authors list (link)
• Diaz-Meco MT, Municio MM, Sanchez P; et al. (1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Mol. Cell. Biol. 16 (1): 105–14. PMID 8524286.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parada NA, Cruikshank WW, Danis HL; et al. (1996). "IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C.". Cell. Immunol. 168 (1): 100–6. doi:10.1006/cimm.1996.0054. PMID 8599832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes". J. Virol. 70 (3): 1384–9. PMID 8627654.CS1 maint: Multiple names: authors list (link)
• Díaz-Meco MT, Municio MM, Frutos S; et al. (1996). "The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C.". Cell. 86 (5): 777–86. PMID 8797824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holmes AM (1996). "In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46". Arch. Biochem. Biophys. 335 (1): 8–12. doi:10.1006/abbi.1996.0476. PMID 8914829.
• Murray NR, Fields AP (1997). "Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis". J. Biol. Chem. 272 (44): 27521–4. PMID 9346882.
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. PMID 9446795.CS1 maint: Multiple names: authors list (link)
• Sanchez P, De Carcer G, Sandoval IV; et al. (1998). "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62". Mol. Cell. Biol. 18 (5): 3069–80. PMID 9566925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)