PPP2R4

Protein phosphatase 2A activator, regulatory subunit 4
File:PBB Protein PPP2R4 image.jpg PDB rendering based on 2g62.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2g62​, 2hv6​, 2hv7​, 2ixm​
Identifiers
Symbols	PPP2R4 ; MGC2184; PP2A; PR53; PTPA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 6149
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PPP2R4 208874 x at tn.png
File:PBB GE PPP2R4 206452 x at tn.png
File:PBB GE PPP2R4 216105 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein phosphatase 2A activator, regulatory subunit 4, also known as PPP2R4, is a human gene.

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis". Curr. HIV Res. 3 (1): 43–51. PMID 15638722.
• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353.
• Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
• Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.CS1 maint: Multiple names: authors list (link)
• Soprano KJ, Purev E, Vuocolo S, Soprano DR (2006). "Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid". Oncogene. 25 (38): 5315–25. doi:10.1038/sj.onc.1209679. PMID 16936753.CS1 maint: Multiple names: authors list (link)
• Jakes S, Mellgren RL, Schlender KK (1986). "Isolation and characterization of an inhibitor-sensitive and a polycation-stimulated protein phosphatase from rat liver nuclei". Biochim. Biophys. Acta. 888 (1): 135–42. PMID 3017441.CS1 maint: Multiple names: authors list (link)
• Turowski P, Fernandez A, Favre B; et al. (1995). "Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression". J. Cell Biol. 129 (2): 397–410. PMID 7721943.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Cayla X, Van Hoof C, Bosch M; et al. (1994). "Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A". J. Biol. Chem. 269 (22): 15668–75. PMID 8195217.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van Hoof C, Aly MS, Garcia A; et al. (1996). "Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A". Genomics. 28 (2): 261–72. doi:10.1006/geno.1995.1140. PMID 8530035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okamoto K, Kamibayashi C, Serrano M; et al. (1996). "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A". Mol. Cell. Biol. 16 (11): 6593–602. PMID 8887688.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tung HY, De Rocquigny H, Zhao LJ; et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. PMID 9013886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hériché JK, Lebrin F, Rabilloud T; et al. (1997). "Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha". Science. 276 (5314): 952–5. PMID 9139659.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.CS1 maint: Multiple names: authors list (link)
• Ogris E, Du X, Nelson KC; et al. (1999). "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". J. Biol. Chem. 274 (20): 14382–91. PMID 10318862.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Janssens V, Van Hoof C, De Baere I; et al. (2000). "Functional analysis of the promoter region of the human phosphotyrosine phosphatase activator gene: Yin Yang 1 is essential for core promoter activity". Biochem. J. 344 Pt 3: 755–63. PMID 10585862.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Janssens V, van Hoof C, Martens E; et al. (2000). "Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene". Eur. J. Biochem. 267 (14): 4406–13. PMID 10880964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMID 10921877.CS1 maint: Multiple names: authors list (link)
• Elder RT, Yu M, Chen M; et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)