PPP1R9B

Protein phosphatase 1, regulatory (inhibitor) subunit 9B
File:PBB Protein PPP1R9B image.jpg PDB rendering based on 2g5m.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2g5m​
Identifiers
Symbols	PPP1R9B ; PPP1R6; FLJ30345; PPP1R9; SPINO
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32787
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PPP1R9B gnf1h00838 at tn.png
File:PBB GE PPP1R9B gnf1h00839 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein phosphatase 1, regulatory (inhibitor) subunit 9B, also known as PPP1R9B, is a human gene.

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997).[supplied by OMIM]

Further reading

• Allen PB, Ouimet CC, Greengard P (1997). "Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9956–61. PMID 9275233.CS1 maint: Multiple names: authors list (link)
• Burnett PE, Blackshaw S, Lai MM; et al. (1998). "Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8351–6. PMID 9653190.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsieh-Wilson LC, Allen PB, Watanabe T; et al. (1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–73. doi:10.1021/bi982900m. PMID 10194355.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith FD, Oxford GS, Milgram SL (1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. 274 (28): 19894–900. PMID 10391935.CS1 maint: Multiple names: authors list (link)
• Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. PMID 10514494.
• Richman JG, Brady AE, Wang Q; et al. (2001). "Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin". J. Biol. Chem. 276 (18): 15003–8. doi:10.1074/jbc.M011679200. PMID 11154706.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vivo M, Calogero RA, Sansone F; et al. (2001). "The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein". J. Biol. Chem. 276 (17): 14161–9. doi:10.1074/jbc.M006845200. PMID 11278317.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grossman SD, Hsieh-Wilson LC, Allen PB; et al. (2003). "The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines". Neuromolecular Med. 2 (1): 61–9. PMID 12230305.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Terry-Lorenzo RT, Elliot E, Weiser DC; et al. (2003). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. PMID 12270929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsieh-Wilson LC, Benfenati F, Snyder GL; et al. (2003). "Phosphorylation of spinophilin modulates its interaction with actin filaments". J. Biol. Chem. 278 (2): 1186–94. doi:10.1074/jbc.M205754200. PMID 12417592.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buchsbaum RJ, Connolly BA, Feig LA (2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". J. Biol. Chem. 278 (21): 18833–41. doi:10.1074/jbc.M207876200. PMID 12531897.CS1 maint: Multiple names: authors list (link)
• Tsukada M, Prokscha A, Oldekamp J, Eichele G (2004). "Identification of neurabin II as a novel doublecortin interacting protein". Mech. Dev. 120 (9): 1033–43. PMID 14550532.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Law AJ, Weickert CS, Hyde TM; et al. (2004). "Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines". The American journal of psychiatry. 161 (10): 1848–55. doi:10.1176/appi.ajp.161.10.1848. PMID 15465982.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)