PPP1R8: Difference between revisions
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'''Nuclear inhibitor of protein phosphatase 1''' is an [[enzyme]] that in humans is encoded by the ''PPP1R8'' [[gene]].<ref name="pmid7524097">{{cite journal |vauthors=Wang M, Cohen SN | title = ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages | journal = Proc Natl Acad Sci USA | volume = 91 | issue = 22 | pages = 10591–5 |date=November 1994 | pmid = 7524097 | pmc = 45067 | doi =10.1073/pnas.91.22.10591 }}</ref><ref name="pmid8473324">{{cite journal |vauthors=Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M | title = ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain | journal = J Biol Chem | volume = 268 | issue = 12 | pages = 8801–7 |date=May 1993 | pmid = 8473324 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5511| accessdate = }}</ref> | '''Nuclear inhibitor of protein phosphatase 1''' is an [[enzyme]] that in humans is encoded by the ''PPP1R8'' [[gene]].<ref name="pmid7524097">{{cite journal |vauthors=Wang M, Cohen SN | title = ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages | journal = Proc Natl Acad Sci USA | volume = 91 | issue = 22 | pages = 10591–5 |date=November 1994 | pmid = 7524097 | pmc = 45067 | doi =10.1073/pnas.91.22.10591 | bibcode =1994PNAS...9110591W }}</ref><ref name="pmid8473324">{{cite journal |vauthors=Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M | title = ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain | journal = J Biol Chem | volume = 268 | issue = 12 | pages = 8801–7 |date=May 1993 | pmid = 8473324 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5511| accessdate = }}</ref> | ||
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==Interactions== | ==Interactions== | ||
PPP1R8 has been shown to [[Protein-protein interaction|interact]] with [[PPP1CA]],<ref name=pmid12788942>{{cite journal |last=Jin |first=Qiming |authorlink= |author2=van Eynde Aleyde |author3=Beullens Monique |author4=Roy Nivedita |author5=Thiel Gerald |author6=Stalmans Willy |author7=Bollen Mathieu |date=August 2003 |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor |journal=J. Biol. Chem. |volume=278 |issue=33 |pages=30677–85 |publisher= |location = United States| issn = 0021-9258| pmid = 12788942 |doi = 10.1074/jbc.M302273200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10637318>{{cite journal |doi=10.1093/nar/28.3.678 |last=Ajuh |first=P M |authorlink= |author2=Browne G J |author3=Hawkes N A |author4=Cohen P T |author5=Roberts S G |author6=Lamond A I |date=February 2000 |title=Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex |journal=Nucleic Acids Res. |volume=28 |issue=3 |pages=678–86 |publisher= |location = ENGLAND| issn = | pmid = 10637318 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=102561 }}</ref> [[Histone deacetylase 2]],<ref name=pmid12788942/> [[SF3B1]]<ref name=pmid12105215>{{cite journal |last=Boudrez |first=An |authorlink= |author2=Beullens Monique |author3=Waelkens Etienne |author4=Stalmans Willy |author5=Bollen Mathieu |date=August 2002 |title=Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1 |journal=J. Biol. Chem. |volume=277 |issue=35 |pages=31834–41 |publisher= |location = United States| issn = 0021-9258| pmid = 12105215 |doi = 10.1074/jbc.M204427200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | PPP1R8 has been shown to [[Protein-protein interaction|interact]] with [[PPP1CA]],<ref name=pmid12788942>{{cite journal |last=Jin |first=Qiming |authorlink= |author2=van Eynde Aleyde |author3=Beullens Monique |author4=Roy Nivedita |author5=Thiel Gerald |author6=Stalmans Willy |author7=Bollen Mathieu |date=August 2003 |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor |journal=J. Biol. Chem. |volume=278 |issue=33 |pages=30677–85 |publisher= |location = United States| issn = 0021-9258| pmid = 12788942 |doi = 10.1074/jbc.M302273200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10637318>{{cite journal |doi=10.1093/nar/28.3.678 |last=Ajuh |first=P M |authorlink= |author2=Browne G J |author3=Hawkes N A |author4=Cohen P T |author5=Roberts S G |author6=Lamond A I |date=February 2000 |title=Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex |journal=Nucleic Acids Res. |volume=28 |issue=3 |pages=678–86 |publisher= |location = ENGLAND| issn = | pmid = 10637318 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=102561 }}</ref> [[Histone deacetylase 2]],<ref name=pmid12788942/> [[SF3B1]]<ref name=pmid12105215>{{cite journal |last=Boudrez |first=An |authorlink= |author2=Beullens Monique |author3=Waelkens Etienne |author4=Stalmans Willy |author5=Bollen Mathieu |date=August 2002 |title=Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1 |journal=J. Biol. Chem. |volume=277 |issue=35 |pages=31834–41 |publisher= |location = United States| issn = 0021-9258| pmid = 12105215 |doi = 10.1074/jbc.M204427200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[EED (protein)|EED]] <ref name=pmid12788942/> and the EZH2 domain of [[PRC2]].<ref name="pmid30305391">{{cite journal |vauthors=Ferreira M, Verbinnen I, Fardilha M, Van Eynde A, Bollen M |title=The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2 |journal=J. Biol. Chem. |volume=293 |issue=47 |pages=18031–18039 |date=November 2018 |pmid=30305391 |doi=10.1074/jbc.AC118.005577 |url=}}</ref> | ||
==References== | ==References== | ||
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*{{cite journal |vauthors=Beullens M, Bollen M |title=The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19855–60 |year= 2002 |pmid= 11909864 |doi= 10.1074/jbc.M200847200 }} | *{{cite journal |vauthors=Beullens M, Bollen M |title=The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19855–60 |year= 2002 |pmid= 11909864 |doi= 10.1074/jbc.M200847200 }} | ||
*{{cite journal |vauthors=Boudrez A, Beullens M, Waelkens E, etal |title=Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31834–41 |year= 2002 |pmid= 12105215 |doi= 10.1074/jbc.M204427200 }} | *{{cite journal |vauthors=Boudrez A, Beullens M, Waelkens E, etal |title=Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31834–41 |year= 2002 |pmid= 12105215 |doi= 10.1074/jbc.M204427200 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Ammosova T, Jerebtsova M, Beullens M, etal |title=Nuclear protein phosphatase-1 regulates HIV-1 transcription. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32189–94 |year= 2003 |pmid= 12788939 |doi= 10.1074/jbc.M300521200 }} | *{{cite journal |vauthors=Ammosova T, Jerebtsova M, Beullens M, etal |title=Nuclear protein phosphatase-1 regulates HIV-1 transcription. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32189–94 |year= 2003 |pmid= 12788939 |doi= 10.1074/jbc.M300521200 }} | ||
*{{cite journal |vauthors=Jin Q, van Eynde A, Beullens M, etal |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30677–85 |year= 2003 |pmid= 12788942 |doi= 10.1074/jbc.M302273200 }} | *{{cite journal |vauthors=Jin Q, van Eynde A, Beullens M, etal |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30677–85 |year= 2003 |pmid= 12788942 |doi= 10.1074/jbc.M302273200 }} | ||
Latest revision as of 00:44, 6 December 2018
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Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.[1][2][3]
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.[3]
Interactions
PPP1R8 has been shown to interact with PPP1CA,[4][5] Histone deacetylase 2,[4] SF3B1[6] EED [4] and the EZH2 domain of PRC2.[7]
References
- ↑ Wang M, Cohen SN (November 1994). "ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages". Proc Natl Acad Sci USA. 91 (22): 10591–5. Bibcode:1994PNAS...9110591W. doi:10.1073/pnas.91.22.10591. PMC 45067. PMID 7524097.
- ↑ Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (May 1993). "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain". J Biol Chem. 268 (12): 8801–7. PMID 8473324.
- ↑ 3.0 3.1 "Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8".
- ↑ 4.0 4.1 4.2 Jin, Qiming; van Eynde Aleyde; Beullens Monique; Roy Nivedita; Thiel Gerald; Stalmans Willy; Bollen Mathieu (August 2003). "The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor". J. Biol. Chem. United States. 278 (33): 30677–85. doi:10.1074/jbc.M302273200. ISSN 0021-9258. PMID 12788942.
- ↑ Ajuh, P M; Browne G J; Hawkes N A; Cohen P T; Roberts S G; Lamond A I (February 2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. ENGLAND. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318.
- ↑ Boudrez, An; Beullens Monique; Waelkens Etienne; Stalmans Willy; Bollen Mathieu (August 2002). "Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1". J. Biol. Chem. United States. 277 (35): 31834–41. doi:10.1074/jbc.M204427200. ISSN 0021-9258. PMID 12105215.
- ↑ Ferreira M, Verbinnen I, Fardilha M, Van Eynde A, Bollen M (November 2018). "The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2". J. Biol. Chem. 293 (47): 18031–18039. doi:10.1074/jbc.AC118.005577. PMID 30305391.
Further reading
- Van Eynde A, Wera S, Beullens M, et al. (1996). "Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing". J. Biol. Chem. 270 (47): 28068–74. doi:10.1074/jbc.270.47.28068. PMID 7499293.
- Claverie-Martin F, Wang M, Cohen SN (1997). "ARD-1 cDNA from human cells encodes a site-specific single-strand endoribonuclease that functionally resembles Escherichia coli RNase E.". J. Biol. Chem. 272 (21): 13823–8. doi:10.1074/jbc.272.21.13823. PMID 9153239.
- Vulsteke V, Beullens M, Waelkens E, et al. (1998). "Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1)". J. Biol. Chem. 272 (52): 32972–8. doi:10.1074/jbc.272.52.32972. PMID 9407077.
- Van Eynde A, Pérez-Callejón E, Schoenmakers E, et al. (1999). "Organization and alternate splice products of the gene encoding nuclear inhibitor of protein phosphatase-1 (NIPP-1)". Eur. J. Biochem. 261 (1): 291–300. doi:10.1046/j.1432-1327.1999.00272.x. PMID 10103062.
- Jin Q, Beullens M, Jagiello I, et al. (1999). "Mapping of the RNA-binding and endoribonuclease domains of NIPP1, a nuclear targeting subunit of protein phosphatase 1". Biochem. J. 342. ( Pt 1) (1): 13–9. doi:10.1042/0264-6021:3420013. PMC 1220430. PMID 10432294.
- Chang AC, Sohlberg B, Trinkle-Mulcahy L, et al. (2000). "Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene". Gene. 240 (1): 45–55. doi:10.1016/S0378-1119(99)00435-7. PMID 10564811.
- Boudrez A, Beullens M, Groenen P, et al. (2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry". J. Biol. Chem. 275 (33): 25411–7. doi:10.1074/jbc.M001676200. PMID 10827081.
- Jagiello I, Van Eynde A, Vulsteke V, et al. (2001). "Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1". J. Cell Sci. 113. Pt 21: 3761–8. PMID 11034904.
- Beullens M, Vulsteke V, Van Eynde A, et al. (2001). "The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding". Biochem. J. 352. Pt 3: 651–8. PMC 1221501. PMID 11104670.
- Trinkle-Mulcahy L, Sleeman JE, Lamond AI (2002). "Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells". J. Cell Sci. 114 (Pt 23): 4219–28. PMID 11739654.
- Beullens M, Bollen M (2002). "The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly". J. Biol. Chem. 277 (22): 19855–60. doi:10.1074/jbc.M200847200. PMID 11909864.
- Boudrez A, Beullens M, Waelkens E, et al. (2002). "Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1". J. Biol. Chem. 277 (35): 31834–41. doi:10.1074/jbc.M204427200. PMID 12105215.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ammosova T, Jerebtsova M, Beullens M, et al. (2003). "Nuclear protein phosphatase-1 regulates HIV-1 transcription". J. Biol. Chem. 278 (34): 32189–94. doi:10.1074/jbc.M300521200. PMID 12788939.
- Jin Q, van Eynde A, Beullens M, et al. (2003). "The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor". J. Biol. Chem. 278 (33): 30677–85. doi:10.1074/jbc.M302273200. PMID 12788942.
- Vulsteke V, Beullens M, Boudrez A, et al. (2004). "Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1". J. Biol. Chem. 279 (10): 8642–7. doi:10.1074/jbc.M311466200. PMID 14699119.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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