PPP1R1B: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (task, replaced: Clinical Cancer Research : an Official Journal of the American Association for Cancer Research → Clinical Cancer Research using AWB)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein phosphatase 1 regulatory subunit 1B''' (PPP1R1B), also known as '''dopamine- and cAMP-regulated neuronal phosphoprotein''' (DARPP-32), is a [[protein]] that in humans is encoded by the ''PPP1R1B'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84152| accessdate = }}</ref><ref name="pmid8120638">{{cite journal |vauthors=Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H | title = Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue | journal = J. Neurosci. | volume = 14 | issue = 3 Pt 1 | pages = 985–98 |date=March 1994 | pmid = 8120638 | doi = | url = http://www.jneurosci.org/cgi/content/abstract/14/3/985 | issn = }}</ref>
| update_page = yes
 
| require_manual_inspection = no
== Function ==
| update_protein_box = yes
 
| update_summary = yes
Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through [[dopaminergic pathways]] has been implicated in several major neurologic and psychiatric disorders. One well studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons<ref name="pmid2191086">{{cite journal |vauthors=Ouimet CC, Greengard P | title = Distribution of DARPP-32 in the basal ganglia: an electron microscopic study | journal = J. Neurocytol. | volume = 19 | issue = 1 | pages = 39–52 |date=February 1990 | pmid = 2191086 | doi = 10.1007/BF01188438| url = | issn = }}</ref> that also express [[dopamine receptor D1|dopamine D1 receptors]].<ref name="pmid6319627">{{cite journal |vauthors=Walaas SI, Greengard P | title = DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain | journal = J. Neurosci. | volume = 4 | issue = 1 | pages = 84–98 |date=January 1984 | pmid = 6319627 | doi = | url = http://www.jneurosci.org/cgi/content/abstract/4/1/84 | issn = }}</ref> The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic ([[NMDA receptor|NMDA]]) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions.<ref name="pmid2153935">{{cite journal |vauthors=Halpain S, Girault JA, Greengard P | title = Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices | journal = Nature | volume = 343 | issue = 6256 | pages = 369–72 |date=January 1990 | pmid = 2153935 | doi = 10.1038/343369a0 | url =  | bibcode = 1990Natur.343..369H }}</ref> Dopamine D1 receptor stimulation enhances [[cyclic adenosine monophosphate|cAMP]] formation, resulting in the phosphorylation of DARPP32;<ref name="pmid6319627"/> (this is disputed by more recent research that claims cAMP signaling induces dephosphorylation of DARPP32<ref name="pmid11050161">{{cite journal | vauthors = Nishi A, Bibb JA, Snyder GL, Higashi H, Nairn AC, Greengard P | title = Amplification of dopaminergic signaling by a positive feedback loop | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 23 | pages = 12840–5 | year = 2000 | pmid = 11050161 | pmc = 18851 | doi = 10.1073/pnas.220410397 | bibcode = 2000PNAS...9712840N }}</ref>) phosphorylated DARPP32 is a potent protein phosphatase-1 ([[PPP1CA]]) inhibitor.<ref name="pmid6087160">{{cite journal |vauthors=Hemmings HC, Greengard P, Tung HY, Cohen P | title = DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1 | journal = Nature | volume = 310 | issue = 5977 | pages = 503–5 | year = 1984 | pmid = 6087160 | doi = 10.1038/310503a0| url = | issn = | bibcode = 1984Natur.310..503H }}</ref> NMDA receptor stimulation elevates intracellular calcium, which leads to activation of [[calcineurin]] and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32.<ref name="entrez"/><ref name="pmid2153935"/> DARPP-32 is critical for dopamine dependent striatal synaptic plasticity,<ref name="pmid25258080">{{cite journal | vauthors = Yagishita S, Hayashi-Takagi A, Ellis-Davies GC, Urakubo H, Ishii S, Kasai H | title = A critical time window for dopamine actions on the structural plasticity of dendritic spines | journal = Science | volume = 345 | issue = 6204 | pages = 1616–20 | year = 2014 | pmid = 25258080 | pmc = 4225776 | doi =  10.1126/science.1255514| bibcode = 2014Sci...345.1616Y }}</ref> possibly by serving as a dopamine-dependent gating mechanism for calcium/CaMKII signaling.<ref name="pmid27584878">{{cite journal | vauthors = Nair AG, Bhalla US, Hellgren Kotaleski J | title = Role of DARPP-32 and ARPP-21 in the Emergence of Temporal Constraints on Striatal Calcium and Dopamine Integration | journal = PLoS Comput Biol | volume = 12 | issue = 9 | pages = e1005080 | year = 2016 | pmid = 27584878 | pmc = 5008828 | doi =  10.1371/journal.pcbi.1005080| bibcode = 2016PLSCB..12E5080N }}</ref> It has been predicted that DARPP-32, in conjunction with [[ARPP-21]], could also be involved in setting-up of eligibility trace-like temporal window for striatal postsynaptic signaling.<ref name="pmid27584878" />
| update_citations = yes
 
}}
== Clinical significance ==
 
=== CNS ===
 
This gene is also known as ''DARPP-32'', highlighting its role as a  dopamine- and cyclic AMP-regulated phosphoprotein. As such PPP1R1B affects [[dopamine]],<ref name="pmid16189209">{{cite journal |vauthors=Scott L, Forssberg H, Aperia A, Diaz-Heijtz R | title = Locomotor effects of a D1R agonist are DARPP-32 dependent in adult but not weanling mice | journal = Pediatr. Res. | volume = 58 | issue = 4 | pages = 779–83 |date=October 2005 | pmid = 16189209 | doi = 10.1203/01.PDR.0000180553.23507.31 | url =  }}</ref> [[glutamate]] and [[adenosine]]; and there is some support for a role of the gene in [[schizophrenia]], as well as being involved in the action of  drugs including cocaine, amphetamine, nicotine, LSD, caffeine, PCP, ethanol and morphine,<ref name="pmid16353915">{{cite journal |vauthors=Svenningsson P, Nairn AC, Greengard P | title = DARPP-32 mediates the actions of multiple drugs of abuse | journal = AAPS J | volume = 7 | issue = 2 | pages = E353–60 | year = 2005 | pmid = 16353915 | doi = 10.1208/aapsj070235 | url = | pmc = 2750972  }}</ref> and in [[Parkinson's disease]] or EPS (Extra-pyramidal symptoms).<ref name="pmid16199832">{{cite journal |vauthors=Clinton SM, Ibrahim HM, Frey KA, Davis KL, Haroutunian V, Meador-Woodruff JH | title = Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilin | journal = Am J Psychiatry | volume = 162 | issue = 10 | pages = 1859–71 |date=October 2005 | pmid = 16199832 | doi = 10.1176/appi.ajp.162.10.1859 | url =  }}</ref> DARPP-32 levels are decreased in the [[dorsolateral prefrontal cortex]] and [[lymphocytes]] of both [[schizophrenia]] and [[bipolar disorder]] patients.<ref name="pmid12150646">{{cite journal | doi = 10.1001/archpsyc.59.8.705 |vauthors=Albert KA, Hemmings HC Jr, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE Jr, Greengard P | title = Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia| journal = Arch Gen Psychiatry | volume = 59 | issue = 8 | pages = 705–12 |date=August 2002 | pmid = 12150646 | url =  }}</ref><ref name="pmid17521792">{{cite journal |vauthors=Ishikawa M, Mizukami K, Iwakiri M, Asada T | title = Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorder | journal = Prog Neuropsychopharmacol Biol Psychiatry | volume = 31 | issue = 6 | pages = 1177–81 |date=August 2007 | pmid = 17521792 | doi = 10.1016/j.pnpbp.2007.04.013 | url =  }}</ref><ref name="pmid19059449">{{cite journal |vauthors=Torres KC, Souza BR, Miranda DM, Nicolato R, Neves FS, Barros AG, Dutra WO, Gollob KJ, Correa H, Romano-Silva MA | title = The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder | journal = Prog Neuropsychopharmacol Biol Psychiatry | volume = 33 | issue = 2 | pages = 214–9 |date=March 2009 | pmid = 19059449 | doi = 10.1016/j.pnpbp.2008.10.020 | url =  }}</ref> This alteration is suggested to be related to the pathology, since [[antipsychotics]] do not regulate the expression of DARPP-32.<ref name="pmid17763944">{{cite journal |vauthors=Souza BR, Motta BS, Rosa DV, Torres KC, Castro AA, Comim CM, Sampaio AM, Lima FF, Jeromin A, Quevedo J, Romano-Silva MA | title = DARPP-32 and NCS-1 expression is not altered in brains of rats treated with typical or atypical antipsychotics | journal = Neurochem Res | volume = 33 | issue = 3 | pages = 533–8 |date=August 2008 | pmid = 17763944 | doi = 10.1007/s11064-007-9470-2 | url =  }}</ref><ref name="pmid20565907">{{cite journal |vauthors=Souza BR, Torres KC, Miranda DM, Motta BS, Scotti-Muzzi E, Guimarães MM, Carneiro DS, Rosa DV, Souza RP, Reis HJ, Jeromin A, Romano-Silva MA | title = Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1 | journal = J Negat Results Biomed | volume = 9 | issue =  | pages = 4 |date=June 2010 | pmid = 20565907 | pmc = 2912242 | doi = 10.1186/1477-5751-9-4 | url =  }}</ref>
 
A considerable proportion of the psychomotor effects of cannabinoids can be accounted for by a signaling cascade in striatal projection neurons involving PKA-dependent [[phosphorylation]] of DARPP-32, achieved via modulation of dopamine D2 and adenosine A2A transmission.<ref name="pmid16162925">{{cite journal |vauthors=Andersson M, Usiello A, Borgkvist A, Pozzi L, Dominguez C, Fienberg AA, Svenningsson P, Fredholm BB, Borrelli E, Greengard P, Fisone G | title = Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons | journal = J. Neurosci. | volume = 25 | issue = 37 | pages = 8432–8 |date=September 2005 | pmid = 16162925 | doi = 10.1523/JNEUROSCI.1289-05.2005 | url =  }}</ref>
 
PPP1R1B has also been associated with improved transfer of information between the [[striatum]] and the [[prefrontal cortex]], suggesting that variants of PPP1R1B can in some circumstances lead to improved and more flexible cognition, while, in the presence of other genetic and environmental factors, it may lead to symptoms of schizophrenia.<ref name="pmid17290303">{{cite journal |vauthors=Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg T, Callicott JH, Egan MF, Huffaker SS, Mattay VS, Kolachana B, Kleinman JE, Weinberger DR | title = Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition | journal = J. Clin. Invest. | volume = 117 | issue = 3 | pages = 672–82 |date=March 2007 | pmid = 17290303 | pmc = 1784004 | doi = 10.1172/JCI30413 | url =  }}</ref>
 
=== Cancer ===
 
There are two protein products encoded by PPP1R1B: DARPP-32 and t-Darpp. t-Darpp is a truncated version of DARPP-32 as it is missing the first 36 amino acids at the N-terminus.<ref name="pmid12124342">{{cite journal | vauthors = El-Rifai W, Smith MF, Li G, Beckler A, Carl VS, Montgomery E, Knuutila S, Moskaluk CA, Frierson HF, Powell SM | title = Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP | journal = Cancer Research | volume = 62 | issue = 14 | pages = 4061–4 | year = 2002 | pmid = 12124342 | doi = | url = http://cancerres.aacrjournals.org/content/62/14/4061.short }}</ref> Both isoforms are overexpressed in a number of cancers including those derived from gastric, colon, prostate, esophageal, and breast tissues.<ref name="pmid26872373">{{cite journal | vauthors = Belkhiri A, Zhu S, El-Rifai W | title = DARPP-32: from neurotransmission to cancer | journal = Oncotarget | volume = 7 | issue = 14 | pages = 17631–40 | year = 2016 | pmid = 26872373 | pmc = 4951238 | doi = 10.18632/oncotarget.7268 }}</ref> In Her-2-positive breast cancer cells, t-Darpp overexpression imparts resistance to [[Trastuzumab]] (Herceptin), the chemotherapy drug that shuts down the Her-2 signaling pathway.<ref name="pmid19593441">{{cite journal | vauthors = Gu L, Waliany S, Kane SE | title = Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistance | journal = Plos One | volume = 4 | issue = 7 | pages = e6220 | year = 2009 | pmid = 19593441 | pmc = 2704867 | doi = 10.1371/journal.pone.0006220 }}</ref><ref name="pmid19301121">{{cite journal | vauthors = Hamel S, Bouchard A, Ferrario C, Hassan S, Aguilar-Mahecha A, Buchanan M, Quenneville L, Miller W, Basik M | title = Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers | journal = Breast Cancer Research and Treatment | volume = 120 | issue = 1 | pages = 47–57 | year = 2010 | pmid = 19301121 | doi = 10.1007/s10549-009-0364-7 }}</ref><ref name="pmid18579663">{{cite journal | vauthors = Belkhiri A, Dar AA, Peng DF, Razvi MH, Rinehart C, Arteaga CL, El-Rifai W | title = Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells | journal = Clinical Cancer Research | volume = 14 | issue = 14 | pages = 4564–71 | year = 2008 | pmid = 18579663 | pmc = 2842884 | doi = 10.1158/1078-0432.CCR-08-0121 }}</ref>
 
== Regulation ==
 
[[Brain-derived neurotrophic factor]] regulates the expression of DARPP-32.<ref name="pmid11739615">{{cite journal |vauthors=Stroppolo A, Guinea B, Tian C, Sommer J, Ehrlich ME | title = Role of phosphatidylinositide 3-kinase in brain-derived neurotrophic factor-induced DARPP-32 expression in medium size spiny neurons in vitro | journal = J. Neurochem. | volume = 79 | issue = 5 | pages = 1027–32 |date=December 2001 | pmid = 11739615 | doi = 10.1046/j.1471-4159.2001.00651.x | url =  }}</ref> The [[Akt]] and CDK5/p35 intracelular pathway is suggested to be involved on this regulation.<ref name="pmid17209049">{{cite journal |vauthors=Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME | journal = J. Biol. Chem. | volume = 282 | issue = 10 | pages = 7352–9 | title = AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro. |date=March 2007 | pmid = 17209049 | doi = 10.1074/jbc.M606508200 | url =  }}</ref> Also, [[neuronal calcium sensor-1]] was suggested to modulate the expression of DARPP-32.<ref name="pmid20838877">{{cite journal |vauthors=Souza BR, Torres KC, Miranda DM, Motta BS, Caetano FS, Rosa DV, Souza RP, Giovani A Jr, Carneiro DS, Guimarães MM, Martins-Silva C, Reis HJ, Gomez MV, Jeromin A, Romano-Silva MA | title = Downregulation of the cAMP/PKA Pathway in PC12 Cells Overexpressing NCS-1 | journal = Cell. Mol. Neurobiol. | year = 2010 | pmid = 20838877 | doi = 10.1007/s10571-010-9562-4 | url = | volume = 31 | pages = 135–143 | issue = 1  }}</ref>
 
== Discovery ==


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
PPP1R1B was discovered by [[Paul Greengard]] and his co-workers.<ref name="pmid8120638"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)
| HGNCid = 9287
| Symbol = PPP1R1B
| AltSymbols =; DARPP-32; DARPP32; FLJ20940
| OMIM = 604399
| ECnumber = 
| Homologene = 12972
| MGIid = 94860
| Function = {{GNF_GO|id=GO:0004860 |text = protein kinase inhibitor activity}} {{GNF_GO|id=GO:0004864 |text = protein phosphatase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007621 |text = negative regulation of female receptivity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84152
    | Hs_Ensembl = ENSG00000131771
    | Hs_RefseqProtein = NP_115568
    | Hs_RefseqmRNA = NM_032192
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 35036705
    | Hs_GenLoc_end = 35046403
    | Hs_Uniprot = Q9UD71
    | Mm_EntrezGene = 19049
    | Mm_Ensembl = ENSMUSG00000061718
    | Mm_RefseqmRNA = NM_144828
    | Mm_RefseqProtein = NP_659077
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 98164828
    | Mm_GenLoc_end = 98173885
    | Mm_Uniprot = Q3URF2
  }}
}}
'''Protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)''', also known as '''PPP1R1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84152| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactive pathway map ==
{{PBB_Summary
{{NicotineDopaminergicActivity_WP1602|highlight=PPP1R1B}}
| section_title =  
| summary_text = Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990) that also express dopamine D1 receptors (Walaas and Greengard, 1984). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84152| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal |vauthors=Hemmings HC, Nairn AC, Greengard P | title = DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. II. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1 | journal = J. Biol. Chem. | volume = 259 | issue = 23 | pages = 14491–7 |date=December 1984 | pmid = 6501303 | doi = | url = http://www.jbc.org/cgi/reprint/259/23/14491 | issn = }}
* {{cite journal |vauthors=Zachariou V, Sgambato-Faure V, Sasaki T, Svenningsson P, Berton O, Fienberg AA, Nairn AC, Greengard P, Nestler EJ | title = Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action | journal = Neuropsychopharmacology | volume = 31 | issue = 3 | pages = 555–62 |date=March 2006 | pmid = 16123776 | doi = 10.1038/sj.npp.1300832 | url =  }}
* {{Cite journal | last = Rosack | first =  J | title = DARPP-32 May Be Culprit in Schizophrenia Symptoms | journal = Psychiatric News | volume = 37 | issue = 18 | pages = 24–24 | url = http://pn.psychiatryonline.org/cgi/content/full/37/18/24 |  date = 20 September 2002 | postscript = <!--None--> }}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Meister B, Askergren J, Tunevall G, ''et al.'' |title=Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland. |journal=J. Endocrinol. Invest. |volume=14 |issue= 8 |pages= 655-61 |year= 1992 |pmid= 1663529 |doi=  }}
*{{cite journal   |vauthors=Meister B, Askergren J, Tunevall G, etal |title=Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland |journal=J. Endocrinol. Invest. |volume=14 |issue= 8 |pages= 655–61 |year= 1992 |pmid= 1663529 |doi=  10.1007/bf03347888}}
*{{cite journal | author=Meister B, Schultzberg M, Hemmings HC, ''et al.'' |title=Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization. |journal=J. Auton. Nerv. Syst. |volume=36 |issue= 1 |pages= 75-84 |year= 1992 |pmid= 1721636 |doi=  }}
*{{cite journal   |vauthors=Meister B, Schultzberg M, Hemmings HC, etal |title=Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization |journal=J. Auton. Nerv. Syst. |volume=36 |issue= 1 |pages= 75–84 |year= 1992 |pmid= 1721636 |doi=10.1016/0165-1838(91)90132-M }}
*{{cite journal | author=Meister B, Arvidsson U, Hemmings HC, ''et al.'' |title=Dopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human. |journal=Neurosci. Lett. |volume=131 |issue= 1 |pages= 66-70 |year= 1992 |pmid= 1791981 |doi=  }}
*{{cite journal   |vauthors=Meister B, Arvidsson U, Hemmings HC, etal |title=Dopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human |journal=Neurosci. Lett. |volume=131 |issue= 1 |pages= 66–70 |year= 1992 |pmid= 1791981 |doi=10.1016/0304-3940(91)90338-T }}
*{{cite journal  | author=Halpain S, Girault JA, Greengard P |title=Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices. |journal=Nature |volume=343 |issue= 6256 |pages= 369-72 |year= 1990 |pmid= 2153935 |doi= 10.1038/343369a0 }}
*{{cite journal  |vauthors=Halpain S, Girault JA, Greengard P |title=Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices |journal=Nature |volume=343 |issue= 6256 |pages= 369–72 |year= 1990 |pmid= 2153935 |doi= 10.1038/343369a0 |bibcode=1990Natur.343..369H }}
*{{cite journal  | author=Ouimet CC, Greengard P |title=Distribution of DARPP-32 in the basal ganglia: an electron microscopic study. |journal=J. Neurocytol. |volume=19 |issue= 1 |pages= 39-52 |year= 1990 |pmid= 2191086 |doi=  }}
*{{cite journal  |vauthors=Ouimet CC, Greengard P |title=Distribution of DARPP-32 in the basal ganglia: an electron microscopic study |journal=J. Neurocytol. |volume=19 |issue= 1 |pages= 39–52 |year= 1990 |pmid= 2191086 |doi=10.1007/BF01188438 }}
*{{cite journal | author=Girault JA, Hemmings HC, Williams KR, ''et al.'' |title=Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II. |journal=J. Biol. Chem. |volume=264 |issue= 36 |pages= 21748-59 |year= 1990 |pmid= 2557337 |doi=  }}
*{{cite journal   |vauthors=Girault JA, Hemmings HC, Williams KR, etal |title=Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II |journal=J. Biol. Chem. |volume=264 |issue= 36 |pages= 21748–59 |year= 1990 |pmid= 2557337 |doi=  }}
*{{cite journal  | author=Hemmings HC, Greengard P, Tung HY, Cohen P |title=DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. |journal=Nature |volume=310 |issue= 5977 |pages= 503-5 |year= 1984 |pmid= 6087160 |doi=  }}
*{{cite journal  |vauthors=Hemmings HC, Greengard P, Tung HY, Cohen P |title=DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1 |journal=Nature |volume=310 |issue= 5977 |pages= 503–5 |year= 1984 |pmid= 6087160 |doi=10.1038/310503a0 |bibcode=1984Natur.310..503H }}
*{{cite journal  | author=Walaas SI, Greengard P |title=DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain. |journal=J. Neurosci. |volume=4 |issue= 1 |pages= 84-98 |year= 1984 |pmid= 6319627 |doi=  }}
*{{cite journal  |vauthors=Walaas SI, Greengard P |title=DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain |journal=J. Neurosci. |volume=4 |issue= 1 |pages= 84–98 |year= 1984 |pmid= 6319627 |doi=  }}
*{{cite journal | author=Brené S, Lindefors N, Ehrlich M, ''et al.'' |title=Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. |journal=J. Neurosci. |volume=14 |issue= 3 Pt 1 |pages= 985-98 |year= 1994 |pmid= 8120638 |doi=  }}
*{{cite journal   |vauthors=Brené S, Lindefors N, Ehrlich M, etal |title=Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue |journal=J. Neurosci. |volume=14 |issue= 3 Pt 1 |pages= 985–98 |year= 1994 |pmid= 8120638 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Kwon YG, Huang HB, Desdouits F, ''et al.'' |title=Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 8 |pages= 3536-41 |year= 1997 |pmid= 9108011 |doi=  }}
*{{cite journal   |vauthors=Kwon YG, Huang HB, Desdouits F, etal |title=Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 8 |pages= 3536–41 |year= 1997 |pmid= 9108011 |doi=10.1073/pnas.94.8.3536  | pmc=20474 |bibcode=1997PNAS...94.3536K }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Mayerhofer A, Hemmings HC, Snyder GL, ''et al.'' |title=Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 1 |pages= 257-64 |year= 1999 |pmid= 9920093 |doi=  }}
*{{cite journal   |vauthors=Mayerhofer A, Hemmings HC, Snyder GL, etal |title=Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 1 |pages= 257–64 |year= 1999 |pmid= 9920093 |doi=10.1210/jc.84.1.257 }}
*{{cite journal | author=Bibb JA, Snyder GL, Nishi A, ''et al.'' |title=Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. |journal=Nature |volume=402 |issue= 6762 |pages= 669-71 |year= 2000 |pmid= 10604473 |doi= 10.1038/45251 }}
*{{cite journal   |vauthors=Bibb JA, Snyder GL, Nishi A, etal |title=Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons |journal=Nature |volume=402 |issue= 6762 |pages= 669–71 |year= 2000 |pmid= 10604473 |doi= 10.1038/45251 |bibcode=1999Natur.402..669B }}
*{{cite journal | author=Mayerhofer A, Fritz S, Grünert R, ''et al.'' |title=D1-Receptor, DARPP-32, and PP-1 in the primate corpus luteum and luteinized granulosa cells: evidence for phosphorylation of DARPP-32 by dopamine and human chorionic gonadotropin. |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 12 |pages= 4750-7 |year= 2001 |pmid= 11134138 |doi= }}
*{{cite journal   |vauthors=Mayerhofer A, Fritz S, Grünert R, etal |title=D1-Receptor, DARPP-32, and PP-1 in the primate corpus luteum and luteinized granulosa cells: evidence for phosphorylation of DARPP-32 by dopamine and human chorionic gonadotropin |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 12 |pages= 4750–7 |year= 2001 |pmid= 11134138 |doi=10.1210/jc.85.12.4750  }}
*{{cite journal | author=El-Rifai W, Smith MF, Li G, ''et al.'' |title=Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP. |journal=Cancer Res. |volume=62 |issue= 14 |pages= 4061-4 |year= 2002 |pmid= 12124342 |doi=  }}
*{{cite journal   |vauthors=El-Rifai W, Smith MF, Li G, etal |title=Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP |journal=Cancer Res. |volume=62 |issue= 14 |pages= 4061–4 |year= 2002 |pmid= 12124342 |doi=  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Beckler A, Moskaluk CA, Zaika A, ''et al.'' |title=Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas. |journal=Cancer |volume=98 |issue= 7 |pages= 1547-51 |year= 2003 |pmid= 14508844 |doi= 10.1002/cncr.11654 }}
*{{cite journal   |vauthors=Beckler A, Moskaluk CA, Zaika A, etal |title=Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein in common adenocarcinomas |journal=Cancer |volume=98 |issue= 7 |pages= 1547–51 |year= 2003 |pmid= 14508844 |doi= 10.1002/cncr.11654 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Varis A, Zaika A, Puolakkainen P, ''et al.'' |title=Coamplified and overexpressed genes at ERBB2 locus in gastric cancer. |journal=Int. J. Cancer |volume=109 |issue= 4 |pages= 548-53 |year= 2004 |pmid= 14991576 |doi= 10.1002/ijc.20001 }}
*{{cite journal   |vauthors=Varis A, Zaika A, Puolakkainen P, etal |title=Coamplified and overexpressed genes at ERBB2 locus in gastric cancer |journal=Int. J. Cancer |volume=109 |issue= 4 |pages= 548–53 |year= 2004 |pmid= 14991576 |doi= 10.1002/ijc.20001 }}
*{{cite journal |vauthors=Stroppolo A, Guinea B, Tian C, Sommer J, Ehrlich ME | title = Role of phosphatidylinositide 3-kinase in brain-derived neurotrophic factor-induced DARPP-32 expression in medium size spiny neurons in vitro | journal = J. Neurochem. | volume = 79 | issue = 5 | pages = 1027–32 |date=December 2001 | pmid = 11739615 | doi = 10.1046/j.1471-4159.2001.00651.x }}
*{{cite journal |vauthors=Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME | title = AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro | journal = J. Biol. Chem. | volume = 282 | issue = 10 | pages = 7352–9 |date=March 2007 | pmid = 17209049 | doi = 10.1074/jbc.M606508200 }}
*{{cite journal |vauthors=Souza BR, Torres KC, Miranda DM, Motta BS, Caetano FS, Rosa DV, Souza RP, Giovani A Jr, Carneiro DS, Guimarães MM, Martins-Silva C, Reis HJ, Gomez MV, Jeromin A, Romano-Silva MA | title = Downregulation of the cAMP/PKA Pathway in PC12 Cells Overexpressing NCS-1 | journal = Cell. Mol. Neurobiol. | year = 2010 | pmid = 20838877 | doi = 10.1007/s10571-010-9562-4 | volume = 31 | pages = 135–143 | issue = 1 }}
*{{cite journal | doi = 10.1001/archpsyc.59.8.705 |vauthors=Albert KA, Hemmings HC Jr, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE Jr, Greengard P | title = Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia| journal = Arch Gen Psychiatry| volume = 59 | issue = 8 | pages = 705–12 |date=August 2002 | pmid = 12150646 }}
*{{cite journal |vauthors=Ishikawa M, Mizukami K, Iwakiri M, Asada T | title = Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorder | journal = Prog Neuropsychopharmacol Biol Psychiatry | volume = 31 | issue = 6 | pages = 1177–81 |date=August 2007 | pmid = 17521792 | doi = 10.1016/j.pnpbp.2007.04.013 }}
*{{cite journal |vauthors=Souza BR, Motta BS, Rosa DV, Torres KC, Castro AA, Comim CM, Sampaio AM, Lima FF, Jeromin A, Quevedo J, Romano-Silva MA | title = DARPP-32 and NCS-1 expression is not altered in brains of rats treated with typical or atypical antipsychotics | journal = Neurochem Res | volume = 33 | issue = 3 | pages = 533–8 |date=August 2008 | pmid = 17763944 | doi = 10.1007/s11064-007-9470-2 }}
*{{cite journal |vauthors=Souza BR, Torres KC, Miranda DM, Motta BS, Scotti-Muzzi E, Guimarães MM, Carneiro DS, Rosa DV, Souza RP, Reis HJ, Jeromin A, Romano-Silva MA | title = Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1 | journal = J Negat Results Biomed | volume = 9 | issue =  | pages = 4 |date=June 2010 | pmid = 20565907 | pmc = 2912242 | doi = 10.1186/1477-5751-9-4 }}
*{{cite journal |vauthors=Torres KC, Souza BR, Miranda DM, Nicolato R, Neves FS, Barros AG, Dutra WO, Gollob KJ, Correa H, Romano-Silva MA | title = The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder | journal = Prog Neuropsychopharmacol Biol Psychiatry | volume = 33 | issue = 2 | pages = 214–9 |date=March 2009 | pmid = 19059449 | doi = 10.1016/j.pnpbp.2008.10.020 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{WikiDoc Sources}}
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}

Revision as of 14:12, 26 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene.[1][2]

Function

Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons[3] that also express dopamine D1 receptors.[4] The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions.[5] Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32;[4] (this is disputed by more recent research that claims cAMP signaling induces dephosphorylation of DARPP32[6]) phosphorylated DARPP32 is a potent protein phosphatase-1 (PPP1CA) inhibitor.[7] NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32.[1][5] DARPP-32 is critical for dopamine dependent striatal synaptic plasticity,[8] possibly by serving as a dopamine-dependent gating mechanism for calcium/CaMKII signaling.[9] It has been predicted that DARPP-32, in conjunction with ARPP-21, could also be involved in setting-up of eligibility trace-like temporal window for striatal postsynaptic signaling.[9]

Clinical significance

CNS

This gene is also known as DARPP-32, highlighting its role as a dopamine- and cyclic AMP-regulated phosphoprotein. As such PPP1R1B affects dopamine,[10] glutamate and adenosine; and there is some support for a role of the gene in schizophrenia, as well as being involved in the action of drugs including cocaine, amphetamine, nicotine, LSD, caffeine, PCP, ethanol and morphine,[11] and in Parkinson's disease or EPS (Extra-pyramidal symptoms).[12] DARPP-32 levels are decreased in the dorsolateral prefrontal cortex and lymphocytes of both schizophrenia and bipolar disorder patients.[13][14][15] This alteration is suggested to be related to the pathology, since antipsychotics do not regulate the expression of DARPP-32.[16][17]

A considerable proportion of the psychomotor effects of cannabinoids can be accounted for by a signaling cascade in striatal projection neurons involving PKA-dependent phosphorylation of DARPP-32, achieved via modulation of dopamine D2 and adenosine A2A transmission.[18]

PPP1R1B has also been associated with improved transfer of information between the striatum and the prefrontal cortex, suggesting that variants of PPP1R1B can in some circumstances lead to improved and more flexible cognition, while, in the presence of other genetic and environmental factors, it may lead to symptoms of schizophrenia.[19]

Cancer

There are two protein products encoded by PPP1R1B: DARPP-32 and t-Darpp. t-Darpp is a truncated version of DARPP-32 as it is missing the first 36 amino acids at the N-terminus.[20] Both isoforms are overexpressed in a number of cancers including those derived from gastric, colon, prostate, esophageal, and breast tissues.[21] In Her-2-positive breast cancer cells, t-Darpp overexpression imparts resistance to Trastuzumab (Herceptin), the chemotherapy drug that shuts down the Her-2 signaling pathway.[22][23][24]

Regulation

Brain-derived neurotrophic factor regulates the expression of DARPP-32.[25] The Akt and CDK5/p35 intracelular pathway is suggested to be involved on this regulation.[26] Also, neuronal calcium sensor-1 was suggested to modulate the expression of DARPP-32.[27]

Discovery

PPP1R1B was discovered by Paul Greengard and his co-workers.[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
<imagemap> Image:NicotineDopaminergic_WP1602.png
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
<imagemap> Image:NicotineDopaminergic_WP1602.png
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

  1. ↑ 1.0 1.1 "Entrez Gene: PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)".
  2. ↑ 2.0 2.1 Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (March 1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". J. Neurosci. 14 (3 Pt 1): 985–98. PMID 8120638.
  3. ↑ Ouimet CC, Greengard P (February 1990). "Distribution of DARPP-32 in the basal ganglia: an electron microscopic study". J. Neurocytol. 19 (1): 39–52. doi:10.1007/BF01188438. PMID 2191086.
  4. ↑ 4.0 4.1 Walaas SI, Greengard P (January 1984). "DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain". J. Neurosci. 4 (1): 84–98. PMID 6319627.
  5. ↑ 5.0 5.1 Halpain S, Girault JA, Greengard P (January 1990). "Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices". Nature. 343 (6256): 369–72. Bibcode:1990Natur.343..369H. doi:10.1038/343369a0. PMID 2153935.
  6. ↑ Nishi A, Bibb JA, Snyder GL, Higashi H, Nairn AC, Greengard P (2000). "Amplification of dopaminergic signaling by a positive feedback loop". Proceedings of the National Academy of Sciences of the United States of America. 97 (23): 12840–5. Bibcode:2000PNAS...9712840N. doi:10.1073/pnas.220410397. PMC 18851. PMID 11050161.
  7. ↑ Hemmings HC, Greengard P, Tung HY, Cohen P (1984). "DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1". Nature. 310 (5977): 503–5. Bibcode:1984Natur.310..503H. doi:10.1038/310503a0. PMID 6087160.
  8. ↑ Yagishita S, Hayashi-Takagi A, Ellis-Davies GC, Urakubo H, Ishii S, Kasai H (2014). "A critical time window for dopamine actions on the structural plasticity of dendritic spines". Science. 345 (6204): 1616–20. Bibcode:2014Sci...345.1616Y. doi:10.1126/science.1255514. PMC 4225776. PMID 25258080.
  9. ↑ 9.0 9.1 Nair AG, Bhalla US, Hellgren Kotaleski J (2016). "Role of DARPP-32 and ARPP-21 in the Emergence of Temporal Constraints on Striatal Calcium and Dopamine Integration". PLoS Comput Biol. 12 (9): e1005080. Bibcode:2016PLSCB..12E5080N. doi:10.1371/journal.pcbi.1005080. PMC 5008828. PMID 27584878.
  10. ↑ Scott L, Forssberg H, Aperia A, Diaz-Heijtz R (October 2005). "Locomotor effects of a D1R agonist are DARPP-32 dependent in adult but not weanling mice". Pediatr. Res. 58 (4): 779–83. doi:10.1203/01.PDR.0000180553.23507.31. PMID 16189209.
  11. ↑ Svenningsson P, Nairn AC, Greengard P (2005). "DARPP-32 mediates the actions of multiple drugs of abuse". AAPS J. 7 (2): E353–60. doi:10.1208/aapsj070235. PMC 2750972. PMID 16353915.
  12. ↑ Clinton SM, Ibrahim HM, Frey KA, Davis KL, Haroutunian V, Meador-Woodruff JH (October 2005). "Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilin". Am J Psychiatry. 162 (10): 1859–71. doi:10.1176/appi.ajp.162.10.1859. PMID 16199832.
  13. ↑ Albert KA, Hemmings HC Jr, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE Jr, Greengard P (August 2002). "Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia". Arch Gen Psychiatry. 59 (8): 705–12. doi:10.1001/archpsyc.59.8.705. PMID 12150646.
  14. ↑ Ishikawa M, Mizukami K, Iwakiri M, Asada T (August 2007). "Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorder". Prog Neuropsychopharmacol Biol Psychiatry. 31 (6): 1177–81. doi:10.1016/j.pnpbp.2007.04.013. PMID 17521792.
  15. ↑ Torres KC, Souza BR, Miranda DM, Nicolato R, Neves FS, Barros AG, Dutra WO, Gollob KJ, Correa H, Romano-Silva MA (March 2009). "The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder". Prog Neuropsychopharmacol Biol Psychiatry. 33 (2): 214–9. doi:10.1016/j.pnpbp.2008.10.020. PMID 19059449.
  16. ↑ Souza BR, Motta BS, Rosa DV, Torres KC, Castro AA, Comim CM, Sampaio AM, Lima FF, Jeromin A, Quevedo J, Romano-Silva MA (August 2008). "DARPP-32 and NCS-1 expression is not altered in brains of rats treated with typical or atypical antipsychotics". Neurochem Res. 33 (3): 533–8. doi:10.1007/s11064-007-9470-2. PMID 17763944.
  17. ↑ Souza BR, Torres KC, Miranda DM, Motta BS, Scotti-Muzzi E, Guimarães MM, Carneiro DS, Rosa DV, Souza RP, Reis HJ, Jeromin A, Romano-Silva MA (June 2010). "Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1". J Negat Results Biomed. 9: 4. doi:10.1186/1477-5751-9-4. PMC 2912242. PMID 20565907.
  18. ↑ Andersson M, Usiello A, Borgkvist A, Pozzi L, Dominguez C, Fienberg AA, Svenningsson P, Fredholm BB, Borrelli E, Greengard P, Fisone G (September 2005). "Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons". J. Neurosci. 25 (37): 8432–8. doi:10.1523/JNEUROSCI.1289-05.2005. PMID 16162925.
  19. ↑ Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg T, Callicott JH, Egan MF, Huffaker SS, Mattay VS, Kolachana B, Kleinman JE, Weinberger DR (March 2007). "Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition". J. Clin. Invest. 117 (3): 672–82. doi:10.1172/JCI30413. PMC 1784004. PMID 17290303.
  20. ↑ El-Rifai W, Smith MF, Li G, Beckler A, Carl VS, Montgomery E, Knuutila S, Moskaluk CA, Frierson HF, Powell SM (2002). "Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP". Cancer Research. 62 (14): 4061–4. PMID 12124342.
  21. ↑ Belkhiri A, Zhu S, El-Rifai W (2016). "DARPP-32: from neurotransmission to cancer". Oncotarget. 7 (14): 17631–40. doi:10.18632/oncotarget.7268. PMC 4951238. PMID 26872373.
  22. ↑ Gu L, Waliany S, Kane SE (2009). "Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistance". Plos One. 4 (7): e6220. doi:10.1371/journal.pone.0006220. PMC 2704867. PMID 19593441.
  23. ↑ Hamel S, Bouchard A, Ferrario C, Hassan S, Aguilar-Mahecha A, Buchanan M, Quenneville L, Miller W, Basik M (2010). "Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers". Breast Cancer Research and Treatment. 120 (1): 47–57. doi:10.1007/s10549-009-0364-7. PMID 19301121.
  24. ↑ Belkhiri A, Dar AA, Peng DF, Razvi MH, Rinehart C, Arteaga CL, El-Rifai W (2008). "Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells". Clinical Cancer Research. 14 (14): 4564–71. doi:10.1158/1078-0432.CCR-08-0121. PMC 2842884. PMID 18579663.
  25. ↑ Stroppolo A, Guinea B, Tian C, Sommer J, Ehrlich ME (December 2001). "Role of phosphatidylinositide 3-kinase in brain-derived neurotrophic factor-induced DARPP-32 expression in medium size spiny neurons in vitro". J. Neurochem. 79 (5): 1027–32. doi:10.1046/j.1471-4159.2001.00651.x. PMID 11739615.
  26. ↑ Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME (March 2007). "AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro". J. Biol. Chem. 282 (10): 7352–9. doi:10.1074/jbc.M606508200. PMID 17209049.
  27. ↑ Souza BR, Torres KC, Miranda DM, Motta BS, Caetano FS, Rosa DV, Souza RP, Giovani A Jr, Carneiro DS, Guimarães MM, Martins-Silva C, Reis HJ, Gomez MV, Jeromin A, Romano-Silva MA (2010). "Downregulation of the cAMP/PKA Pathway in PC12 Cells Overexpressing NCS-1". Cell. Mol. Neurobiol. 31 (1): 135–143. doi:10.1007/s10571-010-9562-4. PMID 20838877.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=PPP1R1B&oldid=1417814"