PPP1R13B

Protein phosphatase 1, regulatory (inhibitor) subunit 13B
Identifiers
Symbols	PPP1R13B ; ASPP1; KIAA0771; p53BP2-like; p85
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9090
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PPP1R13B 216347 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein phosphatase 1, regulatory (inhibitor) subunit 13B, also known as PPP1R13B, is a human gene.

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.

Further reading

• Liu ZJ, Lu X, Zhong S (2005). "ASPP--Apoptotic specific regulator of p53". Biochim. Biophys. Acta. 1756 (1): 77–80. doi:10.1016/j.bbcan.2005.08.002. PMID 16139958.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. PMID 9872452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Samuels-Lev Y, O'Connor DJ, Bergamaschi D; et al. (2001). "ASPP proteins specifically stimulate the apoptotic function of p53". Mol. Cell. 8 (4): 781–94. PMID 11684014.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heilig R, Eckenberg R, Petit JL; et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bergamaschi D, Samuels Y, Jin B; et al. (2004). "ASPP1 and ASPP2: common activators of p53 family members". Mol. Cell. Biol. 24 (3): 1341–50. PMID 14729977.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F". Cell Death Differ. 12 (4): 377–83. doi:10.1038/sj.cdd.4401575. PMID 15706352.CS1 maint: Multiple names: authors list (link)
• Fogal V, Kartasheva NN, Trigiante G; et al. (2005). "ASPP1 and ASPP2 are new transcriptional targets of E2F". Cell Death Differ. 12 (4): 369–76. doi:10.1038/sj.cdd.4401562. PMID 15731768.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu ZJ, Lu X, Zhang Y; et al. (2005). "Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53". FEBS Lett. 579 (7): 1587–90. doi:10.1016/j.febslet.2005.01.069. PMID 15757645.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bergamaschi D, Samuels Y, Zhong S, Lu X (2005). "Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation". Oncogene. 24 (23): 3836–41. doi:10.1038/sj.onc.1208535. PMID 15782125.CS1 maint: Multiple names: authors list (link)
• Agirre X, Román-Gómez J, Jiménez-Velasco A; et al. (2006). "ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia". Oncogene. 25 (13): 1862–70. doi:10.1038/sj.onc.1209236. PMID 16314841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)