PPP1R13B: Difference between revisions

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{{Infobox_gene}}
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'''Apoptosis-stimulating of p53 protein 1''' is a [[protein]] that in humans is encoded by the ''PPP1R13B'' [[gene]].<ref name="pmid9872452">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 5 | pages = 277–86 |date=Apr 1999 | pmid = 9872452 | pmc =  | doi =10.1093/dnares/5.5.277 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23368| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Protein phosphatase 1, regulatory (inhibitor) subunit 13B
| HGNCid = 14950
| Symbol = PPP1R13B
| AltSymbols =; ASPP1; KIAA0771; p53BP2-like; p85
| OMIM = 606455
| ECnumber = 
| Homologene = 9090
| MGIid = 1336199
| GeneAtlas_image1 = PBB_GE_PPP1R13B_216347_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23368
    | Hs_Ensembl = ENSG00000088808
    | Hs_RefseqProtein = NP_056131
    | Hs_RefseqmRNA = NM_015316
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 103269842
    | Hs_GenLoc_end = 103383649
    | Hs_Uniprot = Q96KQ4
    | Mm_EntrezGene = 21981
    | Mm_Ensembl = ENSMUSG00000021285
    | Mm_RefseqmRNA = NM_011625
    | Mm_RefseqProtein = NP_035755
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 112276265
    | Mm_GenLoc_end = 112320250
    | Mm_Uniprot = Q3UF84
  }}
}}
'''Protein phosphatase 1, regulatory (inhibitor) subunit 13B''', also known as '''PPP1R13B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23368| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23368| accessdate = }}</ref>
| summary_text = This gene encodes a member of the [[ASPP]] (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23368| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Liu ZJ, Lu X, Zhong S |title=ASPP--Apoptotic specific regulator of p53. |journal=Biochim. Biophys. Acta |volume=1756 |issue= 1 |pages= 77-80 |year= 2005 |pmid= 16139958 |doi= 10.1016/j.bbcan.2005.08.002 }}
*{{cite journal  | vauthors=Liu ZJ, Lu X, Zhong S |title=ASPP--Apoptotic specific regulator of p53. |journal=Biochim. Biophys. Acta |volume=1756 |issue= 1 |pages= 77–80 |year= 2005 |pmid= 16139958 |doi= 10.1016/j.bbcan.2005.08.002 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi=  }}
*{{cite journal   |vauthors=Samuels-Lev Y, O'Connor DJ, Bergamaschi D, etal |title=ASPP proteins specifically stimulate the apoptotic function of p53. |journal=Mol. Cell |volume=8 |issue= 4 |pages= 781–94 |year= 2001 |pmid= 11684014 |doi=10.1016/S1097-2765(01)00367-7 }}
*{{cite journal  | author=Samuels-Lev Y, O'Connor DJ, Bergamaschi D, ''et al.'' |title=ASPP proteins specifically stimulate the apoptotic function of p53. |journal=Mol. Cell |volume=8 |issue= 4 |pages= 781-94 |year= 2001 |pmid= 11684014 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Heilig R, Eckenberg R, Petit JL, etal |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
*{{cite journal | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Bergamaschi D, Samuels Y, Jin B, etal |title=ASPP1 and ASPP2: common activators of p53 family members. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1341–50 |year= 2004 |pmid= 14729977 |doi=10.1128/MCB.24.3.1341-1350.2004  | pmc=321425 }}
*{{cite journal | author=Bergamaschi D, Samuels Y, Jin B, ''et al.'' |title=ASPP1 and ASPP2: common activators of p53 family members. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1341-50 |year= 2004 |pmid= 14729977 |doi=  }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | vauthors=Hershko T, Chaussepied M, Oren M, Ginsberg D |title=Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. |journal=Cell Death Differ. |volume=12 |issue= 4 |pages= 377–83 |year= 2005 |pmid= 15706352 |doi= 10.1038/sj.cdd.4401575 }}
*{{cite journal  | author=Hershko T, Chaussepied M, Oren M, Ginsberg D |title=Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. |journal=Cell Death Differ. |volume=12 |issue= 4 |pages= 377-83 |year= 2005 |pmid= 15706352 |doi= 10.1038/sj.cdd.4401575 }}
*{{cite journal   |vauthors=Fogal V, Kartasheva NN, Trigiante G, etal |title=ASPP1 and ASPP2 are new transcriptional targets of E2F. |journal=Cell Death Differ. |volume=12 |issue= 4 |pages= 369–76 |year= 2005 |pmid= 15731768 |doi= 10.1038/sj.cdd.4401562 }}
*{{cite journal | author=Fogal V, Kartasheva NN, Trigiante G, ''et al.'' |title=ASPP1 and ASPP2 are new transcriptional targets of E2F. |journal=Cell Death Differ. |volume=12 |issue= 4 |pages= 369-76 |year= 2005 |pmid= 15731768 |doi= 10.1038/sj.cdd.4401562 }}
*{{cite journal   |vauthors=Liu ZJ, Lu X, Zhang Y, etal |title=Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53. |journal=FEBS Lett. |volume=579 |issue= 7 |pages= 1587–90 |year= 2005 |pmid= 15757645 |doi= 10.1016/j.febslet.2005.01.069 }}
*{{cite journal | author=Liu ZJ, Lu X, Zhang Y, ''et al.'' |title=Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53. |journal=FEBS Lett. |volume=579 |issue= 7 |pages= 1587-90 |year= 2005 |pmid= 15757645 |doi= 10.1016/j.febslet.2005.01.069 }}
*{{cite journal  | vauthors=Bergamaschi D, Samuels Y, Zhong S, Lu X |title=Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. |journal=Oncogene |volume=24 |issue= 23 |pages= 3836–41 |year= 2005 |pmid= 15782125 |doi= 10.1038/sj.onc.1208535 }}
*{{cite journal  | author=Bergamaschi D, Samuels Y, Zhong S, Lu X |title=Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. |journal=Oncogene |volume=24 |issue= 23 |pages= 3836-41 |year= 2005 |pmid= 15782125 |doi= 10.1038/sj.onc.1208535 }}
*{{cite journal   |vauthors=Agirre X, Román-Gómez J, Jiménez-Velasco A, etal |title=ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. |journal=Oncogene |volume=25 |issue= 13 |pages= 1862–70 |year= 2006 |pmid= 16314841 |doi= 10.1038/sj.onc.1209236 }}
*{{cite journal | author=Agirre X, Román-Gómez J, Jiménez-Velasco A, ''et al.'' |title=ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. |journal=Oncogene |volume=25 |issue= 13 |pages= 1862-70 |year= 2006 |pmid= 16314841 |doi= 10.1038/sj.onc.1209236 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-14-stub}}

Latest revision as of 18:33, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.[1][2]

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.[2]

References

  1. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  2. ↑ 2.0 2.1 "Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B".

Further reading



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