PPP1R10: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein phosphatase 1 regulatory subunit 10''' is an [[enzyme]] that in humans is encoded by the ''PPP1R10'' [[gene]]. This gene lies within the [[major histocompatibility complex]] class I region on chromosome 6.<ref name="pmid9461602">{{cite journal | vauthors = Allen PB, Kwon YG, Nairn AC, Greengard P | title = Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit | journal = J Biol Chem | volume = 273 | issue = 7 | pages = 4089–95 |date=Mar 1998 | pmid = 9461602 | pmc =  | doi =10.1074/jbc.273.7.4089  }}</ref><ref name="pmid9784381">{{cite journal | vauthors = Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P | title = Cloning of a new gene (FB19) within HLA class I region | journal = Biochem Biophys Res Commun | volume = 250 | issue = 3 | pages = 555–7 |date=Nov 1998 | pmid = 9784381 | pmc = | doi = 10.1006/bbrc.1998.9354 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5514| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein phosphatase 1, regulatory (inhibitor) subunit 10
| HGNCid = 9284
| Symbol = PPP1R10
| AltSymbols =; CAT53; FB19; PNUTS
| OMIM = 603771
| ECnumber = 
| Homologene = 2033
| MGIid = 1289273
| GeneAtlas_image1 = PBB_GE_PPP1R10_201703_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPP1R10_201702_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004864 |text = protein phosphatase inhibitor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006606 |text = protein import into nucleus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5514
    | Hs_Ensembl = ENSG00000204569
    | Hs_RefseqProtein = NP_002705
    | Hs_RefseqmRNA = NM_002714
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 30676156
    | Hs_GenLoc_end = 30692999
    | Hs_Uniprot = Q96QC0
    | Mm_EntrezGene = 52040
    | Mm_Ensembl = ENSMUSG00000039220
    | Mm_RefseqmRNA = NM_175934
    | Mm_RefseqProtein = NP_787948
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 35525249
    | Mm_GenLoc_end = 35540325
    | Mm_Uniprot = A0PJI3
  }}
}}
'''Protein phosphatase 1, regulatory (inhibitor) subunit 10''', also known as '''PPP1R10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5514| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 ([[PP1]]). The rat protein localizes to the [[cell nucleus|nucleus]] and colocalizes with [[chromatin]] at distinct phases during [[mitosis]].<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis. This gene lies within the major histocompatibility complex class I region on chromosome 6.<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5514| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Totaro A, Rommens JM, Grifa A, etal |title=Hereditary hemochromatosis: generation of a transcription map within a refined and extended map of the HLA class I region. |journal=Genomics |volume=31 |issue= 3 |pages= 319–26 |year= 1997 |pmid= 8838313 |doi= 10.1006/geno.1996.0054 }}
| citations =
*{{cite journal   |vauthors=Kreivi JP, Trinkle-Mulcahy L, Lyon CE, etal |title=Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. |journal=FEBS Lett. |volume=420 |issue= 1 |pages= 57–62 |year= 1998 |pmid= 9450550 |doi=10.1016/S0014-5793(97)01485-3 }}
*{{cite journal | author=Totaro A, Rommens JM, Grifa A, ''et al.'' |title=Hereditary hemochromatosis: generation of a transcription map within a refined and extended map of the HLA class I region. |journal=Genomics |volume=31 |issue= 3 |pages= 319-26 |year= 1997 |pmid= 8838313 |doi= 10.1006/geno.1996.0054 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kreivi JP, Trinkle-Mulcahy L, Lyon CE, ''et al.'' |title=Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. |journal=FEBS Lett. |volume=420 |issue= 1 |pages= 57-62 |year= 1998 |pmid= 9450550 |doi= }}
*{{cite journal   |vauthors=Kim YM, Watanabe T, Allen PB, etal |title=PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13819–28 |year= 2003 |pmid= 12574161 |doi= 10.1074/jbc.M209621200 }}
*{{cite journal  | author=Allen PB, Kwon YG, Nairn AC, Greengard P |title=Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. |journal=J. Biol. Chem. |volume=273 |issue= 7 |pages= 4089-95 |year= 1998 |pmid= 9461602 |doi=  }}
*{{cite journal   |vauthors=Reeder JE, Sowden MP, Messing EM, etal |title=Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line. |journal= Cancer Cell International|volume=3 |issue= 1 |pages= 12 |year=  2003|pmid= 12914669 |doi= 10.1186/1475-2867-3-12 | pmc=183861 }}
*{{cite journal  | author=Totaro A, Grifa A, Carella M, ''et al.'' |title=Cloning of a new gene (FB19) within HLA class I region. |journal=Biochem. Biophys. Res. Commun. |volume=250 |issue= 3 |pages= 555-7 |year= 1998 |pmid= 9784381 |doi= 10.1006/bbrc.1998.9354 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Kim YM, Watanabe T, Allen PB, ''et al.'' |title=PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13819-28 |year= 2003 |pmid= 12574161 |doi= 10.1074/jbc.M209621200 }}
*{{cite journal  | vauthors=Raha-Chowdhury R, Andrews SR, Gruen JR |title=CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease. |journal=Brain Res. Mol. Brain Res. |volume=138 |issue= 1 |pages= 70–83 |year= 2005 |pmid= 15894402 |doi= 10.1016/j.molbrainres.2005.04.001 }}
*{{cite journal | author=Reeder JE, Sowden MP, Messing EM, ''et al.'' |title=Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line. |journal= |volume=3 |issue= 1 |pages= 12 |year=  |pmid= 12914669 |doi= 10.1186/1475-2867-3-12 }}
*{{cite journal   |vauthors=Landsverk HB, Kirkhus M, Bollen M, etal |title=PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. |journal=Biochem. J. |volume=390 |issue= Pt 3 |pages= 709–17 |year= 2006 |pmid= 15907195 |doi= 10.1042/BJ20050678 | pmc=1199665 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Raha-Chowdhury R, Andrews SR, Gruen JR |title=CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease. |journal=Brain Res. Mol. Brain Res. |volume=138 |issue= 1 |pages= 70-83 |year= 2005 |pmid= 15894402 |doi= 10.1016/j.molbrainres.2005.04.001 }}
*{{cite journal   |vauthors=Lee SJ, Lim CJ, Min JK, etal |title=Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2. |journal=Cell Death Differ. |volume=14 |issue= 6 |pages= 1106–16 |year= 2007 |pmid= 17318220 |doi= 10.1038/sj.cdd.4402111 }}
*{{cite journal | author=Landsverk HB, Kirkhus M, Bollen M, ''et al.'' |title=PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. |journal=Biochem. J. |volume=390 |issue= Pt 3 |pages= 709-17 |year= 2006 |pmid= 15907195 |doi= 10.1042/BJ20050678 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Lee SJ, Lim CJ, Min JK, ''et al.'' |title=Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2. |journal=Cell Death Differ. |volume=14 |issue= 6 |pages= 1106-16 |year= 2007 |pmid= 17318220 |doi= 10.1038/sj.cdd.4402111 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-6-stub}}

Latest revision as of 18:33, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.[1][2][3]

Function

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.[3]

References

  1. ↑ Allen PB, Kwon YG, Nairn AC, Greengard P (Mar 1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J Biol Chem. 273 (7): 4089–95. doi:10.1074/jbc.273.7.4089. PMID 9461602.
  2. ↑ Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene (FB19) within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555–7. doi:10.1006/bbrc.1998.9354. PMID 9784381.
  3. ↑ 3.0 3.1 "Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=PPP1R10&oldid=1421083"