POEMS syndrome physical examination
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Common physical examination findings of POEMS syndrome include, organomegaly (hepatomegaly, splenomegaly), peripheral edema/anasarca, ascites, mixed lytic/sclerotic bone lesions, papilledema, skin hyperpigmentation and lymphadenopathy.
- Vital signs of patients with POEMS syndrome are usually normal.
- Nail clubbing
- Thickening of the skin
- Excess hair or hair in unusual places (hypertrichosis)
- Skin angiomas or haemangiomas
- There may be changes reminiscent of scleroderma
- Pleural effusion (decreased or absent breath sounds, decreased tactile fremitus, dullness to percussion)
- Symmetrical, ascending chronic progressive polyneuropathy with both sensory (pin-prick and vibration) and motor disability (motor > sensory)
- Decreased muscle strength
- Absent deep tendon reflexes
- Impaired temperature, position, and vibration senses
- Bones may have sclerotic, lytic with sclerotic rims or mixed sclerotic/lytic lesions with soap-bubble appearance.