PKIA

Protein kinase (cAMP-dependent, catalytic) inhibitor alpha
Identifiers
Symbols	PKIA ; PRKACN1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7473
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PKIA 204612 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein kinase (cAMP-dependent, catalytic) inhibitor alpha, also known as PKIA, is a human gene.

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.

Further reading

• Olsen SR, Uhler MD (1991). "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase". J. Biol. Chem. 266 (17): 11158–62. PMID 1710219.
• Olsen SR, Uhler MD (1992). "Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor". Mol. Endocrinol. 5 (9): 1246–56. PMID 1770951.
• Knighton DR, Zheng JH, Ten Eyck LF; et al. (1991). "Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science. 253 (5018): 414–20. PMID 1862343.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van Patten SM, Heisermann GJ, Cheng HC, Walsh DA (1987). "Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase". J. Biol. Chem. 262 (7): 3398–403. PMID 2434500.CS1 maint: Multiple names: authors list (link)
• Scott JD, Fischer EH, Demaille JG, Krebs EG (1985). "Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 82 (13): 4379–83. PMID 2989819.CS1 maint: Multiple names: authors list (link)
• Scott JD, Glaccum MB, Fischer EH, Krebs EG (1986). "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1613–6. PMID 3456605.CS1 maint: Multiple names: authors list (link)
• Wen W, Taylor SS, Meinkoth JL (1995). "The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated". J. Biol. Chem. 270 (5): 2041–6. PMID 7836431.CS1 maint: Multiple names: authors list (link)
• Baude EJ, Dignam SS, Olsen SR; et al. (1994). "Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor". J. Biol. Chem. 269 (3): 2316–23. PMID 7905001.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baude EJ, Dignam SS, Reimann EM, Uhler MD (1994). "Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors". J. Biol. Chem. 269 (27): 18128–33. PMID 8027074.CS1 maint: Multiple names: authors list (link)
• Fritz CC, Green MR (1997). "HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs". Curr. Biol. 6 (7): 848–54. PMID 8805303.
• Zimmermann B, Chiorini JA, Ma Y; et al. (1999). "PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I.". J. Biol. Chem. 274 (9): 5370–8. PMID 10026146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu J, Yu L, Chen Z; et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. PMID 11978406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gassel M, Breitenlechner CB, Rüger P; et al. (2003). "Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)". J. Mol. Biol. 329 (5): 1021–34. PMID 12798691.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)