PKD2L1: Difference between revisions

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{{Infobox_gene}}
'''Polycystic kidney disease 2-like 1 protein''' also known as '''transient receptor potential polycystic 3''' (TRPP3) is a [[protein]] that in humans is encoded by the ''PKD2L1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9033| accessdate = }}</ref>
== Function ==
TRPP3 is a member of the polycystin protein family. TRPP3 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. TRPP3 may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP3 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.<ref name="entrez"/>
== Interactions ==
PKD2L1 has been shown to [[Protein-protein interaction|interact]] with [[TNNI3]].<ref name="pmid12809519">{{cite journal | vauthors = Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ | title = Troponin I binds polycystin-L and inhibits its calcium-induced channel activation | journal = Biochemistry | volume = 42 | issue = 24 | pages = 7618–25 |date=June 2003 | pmid = 12809519 | doi = 10.1021/bi034210a | url = | issn = }}</ref>
== See also ==
* [[TRPP]]
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  |vauthors=Geng L, Okuhara D, Yu Z, etal |title=Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. |journal=J. Cell Sci. |volume=119 |issue= Pt 7 |pages= 1383–95 |year= 2006 |pmid= 16537653 |doi= 10.1242/jcs.02818 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Li Q, Liu Y, Shen PY, etal |title=Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. |journal=Biochemistry |volume=42 |issue= 24 |pages= 7618–25 |year= 2003 |pmid= 12809519 |doi= 10.1021/bi034210a }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | vauthors=Li Q, Liu Y, Zhao W, Chen XZ |title=The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. |journal=FEBS Lett. |volume=516 |issue= 1–3 |pages= 270–8 |year= 2002 |pmid= 11959145 |doi= 10.1016/S0014-5793(02)02513-9 }}
*{{cite journal  |vauthors=Basora N, Nomura H, Berger UV, etal |title=Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 2 |pages= 293–301 |year= 2002 |pmid= 11805156 |doi=  }}
*{{cite journal  | vauthors=Stayner C, Zhou J |title=Polycystin channels and kidney disease |journal=Trends Pharmacol. Sci. |volume=22 |issue= 11 |pages= 543–6 |year= 2001 |pmid= 11698076 |doi=10.1016/S0165-6147(00)01832-0  }}
*{{cite journal  | vauthors=Guo L, Chen M, Basora N, Zhou J |title=The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism |journal=Mamm. Genome |volume=11 |issue= 1 |pages= 46–50 |year= 2000 |pmid= 10602992 |doi=10.1007/s003350010009  }}
*{{cite journal  |vauthors=Veldhuisen B, Spruit L, Dauwerse HG, etal |title=Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2) |journal=Eur. J. Hum. Genet. |volume=7 |issue= 8 |pages= 860–72 |year= 2000 |pmid= 10602361 |doi= 10.1038/sj.ejhg.5200383 }}
*{{cite journal  |vauthors=Chen XZ, Vassilev PM, Basora N, etal |title=Polycystin-L is a calcium-regulated cation channel permeable to calcium ions |journal=Nature |volume=401 |issue= 6751 |pages= 383–6 |year= 1999 |pmid= 10517637 |doi= 10.1038/43907 }}
*{{cite journal  |vauthors=Tsiokas L, Arnould T, Zhu C, etal |title=Specific association of the gene product of PKD2 with the TRPC1 channel |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3934–9 |year= 1999 |pmid= 10097141 |doi=10.1073/pnas.96.7.3934  | pmc=22398  }}
*{{cite journal  |vauthors=Wu G, Hayashi T, Park JH, etal |title=Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25 |journal=Genomics |volume=54 |issue= 3 |pages= 564–8 |year= 1999 |pmid= 9878261 |doi= 10.1006/geno.1998.5618 }}
*{{cite journal  |vauthors=Nomura H, Turco AE, Pei Y, etal |title=Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25967–73 |year= 1998 |pmid= 9748274 |doi=10.1074/jbc.273.40.25967  }}
}}
{{refend}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Polycystic kidney disease 2-like 1
| HGNCid = 9011
| Symbol = PKD2L1
| AltSymbols =; PCL; PKD2L; PKDL
| OMIM = 604532
| ECnumber = 
| Homologene = 22946
| MGIid = 1352448
| GeneAtlas_image1 = PBB_GE_PKD2L1_221061_at_tn.png
| Function = {{GNF_GO|id=GO:0005227 |text = calcium activated cation channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008092 |text = cytoskeletal protein binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9033
    | Hs_Ensembl = ENSG00000107593
    | Hs_RefseqProtein = NP_057196
    | Hs_RefseqmRNA = NM_016112
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 102037893
    | Hs_GenLoc_end = 102080233
    | Hs_Uniprot = Q9P0L9
    | Mm_EntrezGene = 329064
    | Mm_Ensembl = ENSMUSG00000037578
    | Mm_RefseqmRNA = NM_181422
    | Mm_RefseqProtein = NP_852087
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 44200949
    | Mm_GenLoc_end = 44245753
    | Mm_Uniprot = 
  }}
}}
'''Polycystic kidney disease 2-like 1''', also known as '''PKD2L1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9033| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9033| accessdate = }}</ref>
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Geng L, Okuhara D, Yu Z, ''et al.'' |title=Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. |journal=J. Cell. Sci. |volume=119 |issue= Pt 7 |pages= 1383-95 |year= 2006 |pmid= 16537653 |doi= 10.1242/jcs.02818 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Li Q, Liu Y, Shen PY, ''et al.'' |title=Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. |journal=Biochemistry |volume=42 |issue= 24 |pages= 7618-25 |year= 2003 |pmid= 12809519 |doi= 10.1021/bi034210a }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Li Q, Liu Y, Zhao W, Chen XZ |title=The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. |journal=FEBS Lett. |volume=516 |issue= 1-3 |pages= 270-8 |year= 2002 |pmid= 11959145 |doi=  }}
*{{cite journal  | author=Basora N, Nomura H, Berger UV, ''et al.'' |title=Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 2 |pages= 293-301 |year= 2002 |pmid= 11805156 |doi=  }}
*{{cite journal  | author=Stayner C, Zhou J |title=Polycystin channels and kidney disease. |journal=Trends Pharmacol. Sci. |volume=22 |issue= 11 |pages= 543-6 |year= 2001 |pmid= 11698076 |doi=  }}
*{{cite journal  | author=Guo L, Chen M, Basora N, Zhou J |title=The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. |journal=Mamm. Genome |volume=11 |issue= 1 |pages= 46-50 |year= 2000 |pmid= 10602992 |doi=  }}
*{{cite journal  | author=Veldhuisen B, Spruit L, Dauwerse HG, ''et al.'' |title=Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). |journal=Eur. J. Hum. Genet. |volume=7 |issue= 8 |pages= 860-72 |year= 2000 |pmid= 10602361 |doi= 10.1038/sj.ejhg.5200383 }}
*{{cite journal  | author=Chen XZ, Vassilev PM, Basora N, ''et al.'' |title=Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. |journal=Nature |volume=401 |issue= 6751 |pages= 383-6 |year= 1999 |pmid= 10517637 |doi= 10.1038/43907 }}
*{{cite journal  | author=Tsiokas L, Arnould T, Zhu C, ''et al.'' |title=Specific association of the gene product of PKD2 with the TRPC1 channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3934-9 |year= 1999 |pmid= 10097141 |doi=  }}
*{{cite journal  | author=Wu G, Hayashi T, Park JH, ''et al.'' |title=Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25. |journal=Genomics |volume=54 |issue= 3 |pages= 564-8 |year= 1999 |pmid= 9878261 |doi= 10.1006/geno.1998.5618 }}
*{{cite journal  | author=Nomura H, Turco AE, Pei Y, ''et al.'' |title=Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25967-73 |year= 1998 |pmid= 9748274 |doi=  }}
}}
{{refend}}


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Latest revision as of 20:35, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 3 (TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.[1]

Function

TRPP3 is a member of the polycystin protein family. TRPP3 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. TRPP3 may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP3 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.[1]

Interactions

PKD2L1 has been shown to interact with TNNI3.[2]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1".
  2. ↑ Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ (June 2003). "Troponin I binds polycystin-L and inhibits its calcium-induced channel activation". Biochemistry. 42 (24): 7618–25. doi:10.1021/bi034210a. PMID 12809519.

Further reading



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