PIK3R3

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.[1][2]


Interactions

PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor,[3] IRS1[3][4] and Retinoblastoma protein.[5]

References

  1. Dey BR, Furlanetto RW, Nissley SP (May 1998). "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor". Gene. 209 (1–2): 175–83. doi:10.1016/S0378-1119(98)00045-6. PMID 9524259.
  2. "Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)".
  3. 3.0 3.1 Mothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. UNITED STATES. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. ISSN 0888-8809. PMID 9415396.
  4. Xia, X; Serrero G (Aug 1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. ENGLAND. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. ISSN 0264-6021. PMC 1220424. PMID 10417350.
  5. Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. United States. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. ISSN 0270-7306. PMC 151709. PMID 12588990.

Further reading