PICALM: Difference between revisions

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{{for|the anti-inflammatory ointment called Picalm|Piketoprofen}}
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{{Infobox_gene}}
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'''Phosphatidylinositol binding clathrin assembly protein''', also known as '''PICALM''', is a [[protein]] which in humans is encoded by the ''PICALM'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PICALM phosphatidylinositol binding clathrin assembly protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8301| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PICALM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hf8.
| PDB = {{PDB2|1hf8}}, {{PDB2|1hfa}}, {{PDB2|1hg2}}, {{PDB2|1hg5}}
| Name = Phosphatidylinositol binding clathrin assembly protein
| HGNCid = 15514
| Symbol = PICALM
| AltSymbols =; LAP; CALM; CLTH
| OMIM = 603025
| ECnumber = 
| Homologene = 31429
| MGIid = 2385902
| GeneAtlas_image1 = PBB_GE_PICALM_212506_at_tn.png
| GeneAtlas_image2 = PBB_GE_PICALM_212511_at_tn.png
| GeneAtlas_image3 = PBB_GE_PICALM_215236_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005543 |text = phospholipid binding}} {{GNF_GO|id=GO:0005545 |text = phosphatidylinositol binding}} {{GNF_GO|id=GO:0030276 |text = clathrin binding}}
| Component = {{GNF_GO|id=GO:0005905 |text = coated pit}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8301
    | Hs_Ensembl = ENSG00000073921
    | Hs_RefseqProtein = NP_001008660
    | Hs_RefseqmRNA = NM_001008660
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 85346134
    | Hs_GenLoc_end = 85457756
    | Hs_Uniprot = Q13492
    | Mm_EntrezGene = 233489
    | Mm_Ensembl = ENSMUSG00000039361
    | Mm_RefseqmRNA = NM_146194
    | Mm_RefseqProtein = NP_666306
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 90005765
    | Mm_GenLoc_end = 90072224
    | Mm_Uniprot = Q570Z8
  }}
}}
}}
'''Phosphatidylinositol binding clathrin assembly protein''', also known as '''PICALM''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PICALM phosphatidylinositol binding clathrin assembly protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8301| accessdate = }}</ref>
PICALM has been shown to be associated with [[Alzheimer's Disease]] in recent publications of genome-wide association studies <ref name="entrez">{{cite web | title = Entrez Gene:
PICALM phosphatidylinositol binding clathrin assembly protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8301| accessdate = }}</ref>.
== Interactions ==
== Interactions ==
PICALM has been shown to [[Protein-protein interaction|interact]] with [[CLTC]].<ref name=pmid10436022>{{cite journal |last=Tebar |first=F |authorlink= |coauthors=Bohlander S K, Sorkin A |year=[[1999]]|month=Aug. |title=Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic |journal=Mol. Biol. Cell |volume=10 |issue=8 |pages=2687–702 |publisher= |location = UNITED STATES| issn = 1059-1524| pmid = 10436022 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=25500 }}</ref>
PICALM has been shown to [[Protein-protein interaction|interact]] with [[CLTC]].<ref name=pmid10436022>{{cite journal |last=Tebar |first=F |authorlink= |author2=Bohlander S K |author3=Sorkin A |date=Aug 1999 |title=Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic |journal=Mol. Biol. Cell |volume=10 |issue=8 |pages=2687–702 |publisher= |location = UNITED STATES| issn = 1059-1524| pmid = 10436022 | bibcode = | oclc =| id = | url = http://diposit.ub.edu/dspace/bitstream/2445/25184/1/566402.pdf| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=25500 | doi=10.1091/mbc.10.8.2687}}</ref>


== Clinical significance ==
== Clinical significance ==


In humans, certain [[alleles]] of this gene have been statistically associated with an increased risk of developing late-onset [[Alzheimer's disease]].<ref name="pmid19734902">{{cite journal | author = Harold D, Abraham R, Hollingworth P, ''et al.'' | title = Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | journal = Nat. Genet. | volume = 41| issue = 10| pages = 1088–93| year = 2009 | month = September | pmid = 19734902 | doi = 10.1038/ng.440 | url = | laysummary = http://www.time.com/time/health/article/0,8599,1920745,00.html | laysource = TIME Magazine | laydate = 2009-09-06 | pmc = 2845877 }}</ref>
In humans, certain [[alleles]] of this gene have been statistically associated with an increased risk of developing late-onset [[Alzheimer's disease]].<ref name="pmid19734902">{{cite journal |vauthors=Harold D, Abraham R, Hollingworth P, etal | title = Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | journal = Nat. Genet. | volume = 41| issue = 10| pages = 1088–93|date=September 2009 | pmid = 19734902 | doi = 10.1038/ng.440 | url = | laysummary = http://www.time.com/time/health/article/0,8599,1920745,00.html | laysource = TIME Magazine | laydate = 2009-09-06 | pmc = 2845877 }}</ref>
The association has been independently replicated, however estimates of attributable risk are low <ref name="pmid20460622">{{cite journal |author=Seshadri S, Fitzpatrick AL, Ikram MA, ''et al.'' |title=Genome-wide analysis of genetic loci associated with Alzheimer disease |journal=JAMA |volume=303 |issue=18 |pages=1832–40 |year=2010 |month=May |pmid=20460622 |doi=10.1001/jama.2010.574 |url=}}</ref>


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== References ==
{{PBB_Summary
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==References==
== Further reading ==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Ron D, Habener JF |title=CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. |journal=Genes Dev. |volume=6 |issue= 3 |pages= 439-53 |year= 1992 |pmid= 1547942 |doi= }}
*{{cite journal |vauthors=Ron D, Habener JF |title=CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. |journal=Genes Dev. |volume=6 |issue= 3 |pages= 439–53 |year= 1992 |pmid= 1547942 |doi=10.1101/gad.6.3.439 }}
*{{cite journal  | author=Dreyling MH, Martinez-Climent JA, Zheng M, ''et al.'' |title=The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4804-9 |year= 1996 |pmid= 8643484 |doi= }}
*{{cite journal  |vauthors=Dreyling MH, Martinez-Climent JA, Zheng M, etal |title=The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4804–9 |year= 1996 |pmid= 8643484 |doi= 10.1073/pnas.93.10.4804| pmc=39360 |bibcode=1996PNAS...93.4804D }}
*{{cite journal  | author=Silliman CC, McGavran L, Wei Q, ''et al.'' |title=Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides. |journal=Leukemia |volume=12 |issue= 9 |pages= 1404-10 |year= 1998 |pmid= 9737689 |doi= }}
*{{cite journal  |vauthors=Silliman CC, McGavran L, Wei Q, etal |title=Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides. |journal=Leukemia |volume=12 |issue= 9 |pages= 1404–10 |year= 1998 |pmid= 9737689 |doi=10.1038/sj.leu.2401109 }}
*{{cite journal | author=Tebar F, Bohlander SK, Sorkin A |title=Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. |journal=Mol. Biol. Cell |volume=10 |issue= 8 |pages= 2687-702 |year= 1999 |pmid= 10436022 |doi= }}
*{{cite journal |vauthors=Tebar F, Bohlander SK, Sorkin A |title=Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. |journal=Mol. Biol. Cell |volume=10 |issue= 8 |pages= 2687–702 |year= 1999 |pmid= 10436022 |doi= 10.1091/mbc.10.8.2687| pmc=25500 }}
*{{cite journal  | author=Kim JA, Kim SR, Jung YK, ''et al.'' |title=Properties of GST-CALM expressed in E. coli. |journal=Exp. Mol. Med. |volume=32 |issue= 2 |pages= 93-9 |year= 2000 |pmid= 10926122 |doi= }}
*{{cite journal  |vauthors=Kim JA, Kim SR, Jung YK, etal |title=Properties of GST-CALM expressed in E. coli. |journal=Exp. Mol. Med. |volume=32 |issue= 2 |pages= 93–9 |year= 2000 |pmid= 10926122 |doi= }}
*{{cite journal  | author=Wechsler DS, Engstrom LD, Alexander BM, ''et al.'' |title=A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein. |journal=Genes Chromosomes Cancer |volume=36 |issue= 1 |pages= 26-36 |year= 2003 |pmid= 12461747 |doi= 10.1002/gcc.10136 }}
*{{cite journal  |vauthors=Wechsler DS, Engstrom LD, Alexander BM, etal |title=A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein. |journal=Genes Chromosomes Cancer |volume=36 |issue= 1 |pages= 26–36 |year= 2003 |pmid= 12461747 |doi= 10.1002/gcc.10136 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | author=Park SY, Ha BG, Choi GH, ''et al.'' |title=EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment. |journal=Biochemistry |volume=43 |issue= 23 |pages= 7552-62 |year= 2004 |pmid= 15182197 |doi= 10.1021/bi049970f }}
*{{cite journal  |vauthors=Park SY, Ha BG, Choi GH, etal |title=EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment. |journal=Biochemistry |volume=43 |issue= 23 |pages= 7552–62 |year= 2004 |pmid= 15182197 |doi= 10.1021/bi049970f }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Meyerholz A, Hinrichsen L, Groos S, ''et al.'' |title=Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation. |journal=Traffic |volume=6 |issue= 12 |pages= 1225-34 |year= 2006 |pmid= 16262731 |doi= 10.1111/j.1600-0854.2005.00355.x }}
*{{cite journal  |vauthors=Meyerholz A, Hinrichsen L, Groos S, etal |title=Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation. |journal=Traffic |volume=6 |issue= 12 |pages= 1225–34 |year= 2006 |pmid= 16262731 |doi= 10.1111/j.1600-0854.2005.00355.x }}
*{{cite journal | author=Archangelo LF, Gläsner J, Krause A, Bohlander SK |title=The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10. |journal=Oncogene |volume=25 |issue= 29 |pages= 4099-109 |year= 2006 |pmid= 16491119 |doi= 10.1038/sj.onc.1209438 }}
*{{cite journal |vauthors=Archangelo LF, Gläsner J, Krause A, Bohlander SK |title=The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10. |journal=Oncogene |volume=25 |issue= 29 |pages= 4099–109 |year= 2006 |pmid= 16491119 |doi= 10.1038/sj.onc.1209438 }}
*{{cite journal  | author=Deshpande AJ, Cusan M, Rawat VP, ''et al.'' |title=Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. |journal=Cancer Cell |volume=10 |issue= 5 |pages= 363-74 |year= 2007 |pmid= 17097559 |doi= 10.1016/j.ccr.2006.08.023 }}
*{{cite journal  |vauthors=Deshpande AJ, Cusan M, Rawat VP, etal |title=Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. |journal=Cancer Cell |volume=10 |issue= 5 |pages= 363–74 |year= 2007 |pmid= 17097559 |doi= 10.1016/j.ccr.2006.08.023 }}
*{{cite journal  | author=Abdelhaleem M, Beimnet K, Kirby-Allen M, ''et al.'' |title=High incidence of CALM-AF10 fusion and the identification of a novel fusion transcript in acute megakaryoblastic leukemia in children without Down's syndrome. |journal=Leukemia |volume=21 |issue= 2 |pages= 352-3 |year= 2007 |pmid= 17170719 |doi= 10.1038/sj.leu.2404503 }}
*{{cite journal  |vauthors=Abdelhaleem M, Beimnet K, Kirby-Allen M, etal |title=High incidence of CALM-AF10 fusion and the identification of a novel fusion transcript in acute megakaryoblastic leukemia in children without Down's syndrome. |journal=Leukemia |volume=21 |issue= 2 |pages= 352–3 |year= 2007 |pmid= 17170719 |doi= 10.1038/sj.leu.2404503 }}
*{{cite journal  | author=Ashihara E, Nakamura S, Inaba T, ''et al.'' |title=A novel AF10-CALM fusion transcript in gamma/delta-T cell type lymphoblastic lymphoma. |journal=Am. J. Hematol. |volume=82 |issue= 9 |pages= 859-60 |year= 2007 |pmid= 17597474 |doi= 10.1002/ajh.21021 }}
*{{cite journal  |vauthors=Ashihara E, Nakamura S, Inaba T, etal |title=A novel AF10-CALM fusion transcript in gamma/delta-T cell type lymphoblastic lymphoma. |journal=Am. J. Hematol. |volume=82 |issue= 9 |pages= 859–60 |year= 2007 |pmid= 17597474 |doi= 10.1002/ajh.21021 }}
*{{cite journal | author=Caudell D, Zhang Z, Chung YJ, Aplan PD |title=Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice. |journal=Cancer Res. |volume=67 |issue= 17 |pages= 8022-31 |year= 2007 |pmid= 17804713 |doi= 10.1158/0008-5472.CAN-06-3749 }}
*{{cite journal |vauthors=Caudell D, Zhang Z, Chung YJ, Aplan PD |title=Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice. |journal=Cancer Res. |volume=67 |issue= 17 |pages= 8022–31 |year= 2007 |pmid= 17804713 |doi= 10.1158/0008-5472.CAN-06-3749 | pmc=1986634 }}
}}
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{{PDB Gallery|geneid=8301}}
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Latest revision as of 15:15, 4 November 2018

For the anti-inflammatory ointment called Picalm, see Piketoprofen.
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.[1]

Interactions

PICALM has been shown to interact with CLTC.[2]

Clinical significance

In humans, certain alleles of this gene have been statistically associated with an increased risk of developing late-onset Alzheimer's disease.[3]

References

  1. ↑ "Entrez Gene: PICALM phosphatidylinositol binding clathrin assembly protein".
  2. ↑ Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic" (PDF). Mol. Biol. Cell. UNITED STATES. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022.
  3. ↑ Harold D, Abraham R, Hollingworth P, et al. (September 2009). "Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease". Nat. Genet. 41 (10): 1088–93. doi:10.1038/ng.440. PMC 2845877. PMID 19734902. Lay summary – TIME Magazine (2009-09-06).

Further reading



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