PEX3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Peroxisomal biogenesis factor 3''' is a [[protein]] that in humans is encoded by the ''PEX3'' [[gene]].<ref name="pmid9657383">{{cite journal | vauthors = Kammerer S, Holzinger A, Welsch U, Roscher AA | title = Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p | journal = FEBS Letters | volume = 429 | issue = 1 | pages = 53–60 | date = Jun 1998 | pmid = 9657383 | pmc =  | doi = 10.1016/S0014-5793(98)00557-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PEX3 peroxisomal biogenesis factor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8504| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Peroxisomal biogenesis factor 3
| HGNCid = 8858
| Symbol = PEX3
| AltSymbols =; TRG18
| OMIM = 603164
| ECnumber = 
| Homologene = 2691
| MGIid = 1929646
| GeneAtlas_image1 = PBB_GE_PEX3_203970_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PEX3_203972_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005777 |text = peroxisome}} {{GNF_GO|id=GO:0005779 |text = integral to peroxisomal membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007031 |text = peroxisome organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8504
    | Hs_Ensembl = ENSG00000034693
    | Hs_RefseqProtein = NP_003621
    | Hs_RefseqmRNA = NM_003630
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 143813637
    | Hs_GenLoc_end = 143852840
    | Hs_Uniprot = P56589
    | Mm_EntrezGene = 56535
    | Mm_Ensembl = ENSMUSG00000019809
    | Mm_RefseqmRNA = NM_019961
    | Mm_RefseqProtein = NP_064345
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 13214314
    | Mm_GenLoc_end = 13243292
    | Mm_Uniprot = Q3UIG2
  }}
}}
'''Peroxisomal biogenesis factor 3''', also known as '''PEX3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PEX3 peroxisomal biogenesis factor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8504| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
PEX3 has been shown to [[Protein-protein interaction|interact]] with [[PEX19]].<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network |authorlink30=Huda Zoghbi| journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid11883941>{{cite journal | vauthors = Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC | title = Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly | journal = Biochemical and Biophysical Research Communications | volume = 291 | issue = 5 | pages = 1180–6 | date = Mar 2002 | pmid = 11883941 | doi = 10.1006/bbrc.2002.6568 }}</ref><ref name=pmid10704444>{{cite journal | vauthors = Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ | title = PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis | journal = The Journal of Cell Biology | volume = 148 | issue = 5 | pages = 931–44 | date = Mar 2000 | pmid = 10704444 | pmc = 2174547 | doi = 10.1083/jcb.148.5.931 }}</ref><ref name=pmid11390669>{{cite journal | vauthors = Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP | title = Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences | journal = Molecular and Cellular Biology | volume = 21 | issue = 13 | pages = 4413–24 | date = Jul 2001 | pmid = 11390669 | pmc = 87101 | doi = 10.1128/MCB.21.13.4413-4424.2001 }}</ref>
{{PBB_Summary
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| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = South ST, Gould SJ | title = Peroxisome synthesis in the absence of preexisting peroxisomes | journal = The Journal of Cell Biology | volume = 144 | issue = 2 | pages = 255–66 | date = Jan 1999 | pmid = 9922452 | pmc = 2132891 | doi = 10.1083/jcb.144.2.255 }}
| citations =
* {{cite journal | vauthors = Soukupova M, Sprenger C, Gorgas K, Kunau WH, Dodt G | title = Identification and characterization of the human peroxin PEX3 | journal = European Journal of Cell Biology | volume = 78 | issue = 6 | pages = 357–74 | date = Jun 1999 | pmid = 10430017 | doi = 10.1016/S0171-9335(99)80078-8 }}
*{{cite journal | author=Kammerer S, Holzinger A, Welsch U, Roscher AA |title=Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p. |journal=FEBS Lett. |volume=429 |issue= 1 |pages= 53-60 |year= 1998 |pmid= 9657383 |doi=  }}
* {{cite journal | vauthors = Muntau AC, Holzinger A, Mayerhofer PU, Gärtner J, Roscher AA, Kammerer S | title = The human PEX3 gene encoding a peroxisomal assembly protein: genomic organization, positional mapping, and mutation analysis in candidate phenotypes | journal = Biochemical and Biophysical Research Communications | volume = 268 | issue = 3 | pages = 704–10 | date = Feb 2000 | pmid = 10679269 | doi = 10.1006/bbrc.2000.2193 }}
*{{cite journal  | author=South ST, Gould SJ |title=Peroxisome synthesis in the absence of preexisting peroxisomes. |journal=J. Cell Biol. |volume=144 |issue= 2 |pages= 255-66 |year= 1999 |pmid= 9922452 |doi= }}
* {{cite journal | vauthors = Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ | title = PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis | journal = The Journal of Cell Biology | volume = 148 | issue = 5 | pages = 931–44 | date = Mar 2000 | pmid = 10704444 | pmc = 2174547 | doi = 10.1083/jcb.148.5.931 }}
*{{cite journal | author=Soukupova M, Sprenger C, Gorgas K, ''et al.'' |title=Identification and characterization of the human peroxin PEX3. |journal=Eur. J. Cell Biol. |volume=78 |issue= 6 |pages= 357-74 |year= 1999 |pmid= 10430017 |doi= }}
* {{cite journal | vauthors = Ghaedi K, Tamura S, Okumoto K, Matsuzono Y, Fujiki Y | title = The peroxin pex3p initiates membrane assembly in peroxisome biogenesis | journal = Molecular Biology of the Cell | volume = 11 | issue = 6 | pages = 2085–102 | date = Jun 2000 | pmid = 10848631 | pmc = 14905 | doi = 10.1091/mbc.11.6.2085 }}
*{{cite journal | author=Muntau AC, Holzinger A, Mayerhofer PU, ''et al.'' |title=The human PEX3 gene encoding a peroxisomal assembly protein: genomic organization, positional mapping, and mutation analysis in candidate phenotypes. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 3 |pages= 704-10 |year= 2000 |pmid= 10679269 |doi= 10.1006/bbrc.2000.2193 }}
* {{cite journal | vauthors = Muntau AC, Mayerhofer PU, Paton BC, Kammerer S, Roscher AA | title = Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G | journal = American Journal of Human Genetics | volume = 67 | issue = 4 | pages = 967–75 | date = Oct 2000 | pmid = 10958759 | pmc = 1287898 | doi = 10.1086/303071 }}
*{{cite journal | author=Sacksteder KA, Jones JM, South ST, ''et al.'' |title=PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. |journal=J. Cell Biol. |volume=148 |issue= 5 |pages= 931-44 |year= 2000 |pmid= 10704444 |doi= }}
* {{cite journal | vauthors = Ghaedi K, Honsho M, Shimozawa N, Suzuki Y, Kondo N, Fujiki Y | title = PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G | journal = American Journal of Human Genetics | volume = 67 | issue = 4 | pages = 976–81 | date = Oct 2000 | pmid = 10968777 | pmc = 1287899 | doi = 10.1086/303086 }}
*{{cite journal | author=Ghaedi K, Tamura S, Okumoto K, ''et al.'' |title=The peroxin pex3p initiates membrane assembly in peroxisome biogenesis. |journal=Mol. Biol. Cell |volume=11 |issue= 6 |pages= 2085-102 |year= 2000 |pmid= 10848631 |doi= }}
* {{cite journal | vauthors = Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP | title = Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences | journal = Molecular and Cellular Biology | volume = 21 | issue = 13 | pages = 4413–24 | date = Jul 2001 | pmid = 11390669 | pmc = 87101 | doi = 10.1128/MCB.21.13.4413-4424.2001 }}
*{{cite journal | author=Muntau AC, Mayerhofer PU, Paton BC, ''et al.'' |title=Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G. |journal=Am. J. Hum. Genet. |volume=67 |issue= 4 |pages= 967-75 |year= 2000 |pmid= 10958759 |doi= }}
* {{cite journal | vauthors = Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC | title = Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly | journal = Biochemical and Biophysical Research Communications | volume = 291 | issue = 5 | pages = 1180–6 | date = Mar 2002 | pmid = 11883941 | doi = 10.1006/bbrc.2002.6568 }}
*{{cite journal | author=Ghaedi K, Honsho M, Shimozawa N, ''et al.'' |title=PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G. |journal=Am. J. Hum. Genet. |volume=67 |issue= 4 |pages= 976-81 |year= 2000 |pmid= 10968777 |doi= }}
* {{cite journal | vauthors = Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP | title = Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay | journal = Molecular & Cellular Proteomics | volume = 1 | issue = 3 | pages = 243–52 | date = Mar 2002 | pmid = 12096124 | doi = 10.1074/mcp.M100025-MCP200 }}
*{{cite journal | author=Fransen M, Wylin T, Brees C, ''et al.'' |title=Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences. |journal=Mol. Cell. Biol. |volume=21 |issue= 13 |pages= 4413-24 |year= 2001 |pmid= 11390669 |doi= 10.1128/MCB.21.13.4413-4424.2001 }}
* {{cite journal | vauthors = Muntau AC, Roscher AA, Kunau WH, Dodt G | title = The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis | journal = European Journal of Cell Biology | volume = 82 | issue = 7 | pages = 333–42 | date = Jul 2003 | pmid = 12924628 | doi = 10.1078/0171-9335-00325 }}
*{{cite journal | author=Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC |title=Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 5 |pages= 1180-6 |year= 2002 |pmid= 11883941 |doi= 10.1006/bbrc.2002.6568 }}
* {{cite journal | vauthors = Muntau AC, Roscher AA, Kunau WH, Dodt G | title = Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET) | journal = Advances in Experimental Medicine and Biology | volume = 544 | issue =  | pages = 221–4 | year = 2004 | pmid = 14713233 | doi = 10.1007/978-1-4419-9072-3_27 }}
*{{cite journal | author=Fransen M, Brees C, Ghys K, ''et al.'' |title=Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay. |journal=Mol. Cell Proteomics |volume=1 |issue= 3 |pages= 243-52 |year= 2002 |pmid= 12096124 |doi=  }}
* {{cite journal | vauthors = Fang Y, Morrell JC, Jones JM, Gould SJ | title = PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins | journal = The Journal of Cell Biology | volume = 164 | issue = 6 | pages = 863–75 | date = Mar 2004 | pmid = 15007061 | pmc = 2172291 | doi = 10.1083/jcb.200311131 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Muntau AC, Roscher AA, Kunau WH, Dodt G |title=The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis. |journal=Eur. J. Cell Biol. |volume=82 |issue= 7 |pages= 333-42 |year= 2003 |pmid= 12924628 |doi=  }}
* {{cite journal | vauthors = Matsuzono Y, Matsuzaki T, Fujiki Y | title = Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation | journal = Journal of Cell Science | volume = 119 | issue = Pt 17 | pages = 3539–50 | date = Sep 2006 | pmid = 16895967 | doi = 10.1242/jcs.03100 }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Muntau AC, Roscher AA, Kunau WH, Dodt G |title=Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET). |journal=Adv. Exp. Med. Biol. |volume=544 |issue=  |pages= 221-4 |year= 2004 |pmid= 14713233 |doi= }}
*{{cite journal | author=Fang Y, Morrell JC, Jones JM, Gould SJ |title=PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins. |journal=J. Cell Biol. |volume=164 |issue= 6 |pages= 863-75 |year= 2004 |pmid= 15007061 |doi= 10.1083/jcb.200311131 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Matsuzono Y, Matsuzaki T, Fujiki Y |title=Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation. |journal=J. Cell. Sci. |volume=119 |issue= Pt 17 |pages= 3539-50 |year= 2007 |pmid= 16895967 |doi= 10.1242/jcs.03100 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=pbd  GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]
* [https://www.ncbi.nlm.nih.gov/omim/170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666,170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666 OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]
 
 
{{gene-6-stub}}

Latest revision as of 15:03, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Peroxisomal biogenesis factor 3 is a protein that in humans is encoded by the PEX3 gene.[1][2]

Interactions

PEX3 has been shown to interact with PEX19.[3][4][5][6]

References

  1. Kammerer S, Holzinger A, Welsch U, Roscher AA (Jun 1998). "Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p". FEBS Letters. 429 (1): 53–60. doi:10.1016/S0014-5793(98)00557-2. PMID 9657383.
  2. "Entrez Gene: PEX3 peroxisomal biogenesis factor 3".
  3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  4. Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (Mar 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochemical and Biophysical Research Communications. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
  5. Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (Mar 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
  6. Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (Jul 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.

Further reading

External links