PDGFD

Platelet derived growth factor D
Identifiers
Symbols	PDGFD ; IEGF; MGC26867; MSTP036; SCDGF-B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11875
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDGFD 219304 s at tn.png
File:PBB GE PDGFD gnf1h09263 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Platelet derived growth factor D, also known as PDGFD, is a human gene.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.

Further reading

• Hamada T, Ui-Tei K, Imaki J, Miyata Y (2001). "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein". Biochem. Biophys. Res. Commun. 280 (3): 733–7. doi:10.1006/bbrc.2000.4187. PMID 11162582.CS1 maint: Multiple names: authors list (link)
• Bergsten E, Uutela M, Li X; et al. (2001). "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor". Nat. Cell Biol. 3 (5): 512–6. doi:10.1038/35074588. PMID 11331881.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• LaRochelle WJ, Jeffers M, McDonald WF; et al. (2001). "PDGF-D, a new protease-activated growth factor". Nat. Cell Biol. 3 (5): 517–21. doi:10.1038/35074593. PMID 11331882.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uutela M, Laurén J, Bergsten E; et al. (2001). "Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes". Circulation. 103 (18): 2242–7. PMID 11342471.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• LaRochelle WJ, Jeffers M, Corvalan JR; et al. (2002). "Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer". Cancer Res. 62 (9): 2468–73. PMID 11980634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wistow G, Bernstein SL, Ray S; et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Changsirikulchai S, Hudkins KL, Goodpaster TA; et al. (2003). "Platelet-derived growth factor-D expression in developing and mature human kidneys". Kidney Int. 62 (6): 2043–54. doi:10.1046/j.1523-1755.2002.00662.x. PMID 12427128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taneda S, Hudkins KL, Topouzis S; et al. (2004). "Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury". J. Am. Soc. Nephrol. 14 (10): 2544–55. PMID 14514732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uutela M, Wirzenius M, Paavonen K; et al. (2004). "PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis". Blood. 104 (10): 3198–204. doi:10.1182/blood-2004-04-1485. PMID 15271796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ray S, Gao C, Wyatt K; et al. (2005). "Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation". J. Biol. Chem. 280 (9): 8494–502. doi:10.1074/jbc.M413570200. PMID 15611105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ustach CV, Kim HR (2005). "Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells". Mol. Cell. Biol. 25 (14): 6279–88. doi:10.1128/MCB.25.14.6279-6288.2005. PMID 15988036.
• Liu MY, Eyries M, Zhang C; et al. (2006). "Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1". Blood. 107 (6): 2322–9. doi:10.1182/blood-2005-06-2377. PMID 16189269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)