PDE4B

Phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
File:PBB Protein PDE4B image.jpg PDB rendering based on 1f0j.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1f0j​, 1ro6​, 1ro9​, 1ror​, 1tb5​, 1xlx​, 1xlz​, 1xm4​, 1xm6​, 1xmu​, 1xmy​, 1xn0​, 1xos​, 1xot​, 1y2h​, 1y2j​
Identifiers
Symbols	PDE4B ; DKFZp686F2182; DPDE4; MGC126529; PDEIVB
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1953
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PDE4B 211302 s at tn.png
File:PBB GE PDE4B 203708 at tn.png
File:PBB GE PDE4B gnf1h03574 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila), also known as PDE4B, is a human gene.

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Szpirer C, Szpirer J, Rivière M; et al. (1995). "Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4". Cytogenet. Cell Genet. 69 (1–2): 11–4. PMID 7835077.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bolger GB, Rodgers L, Riggs M (1994). "Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases". Gene. 149 (2): 237–44. PMID 7958996.CS1 maint: Multiple names: authors list (link)
• Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat. Cell Mol. Genet. 20 (2): 75–86. PMID 8009369.CS1 maint: Multiple names: authors list (link)
• McLaughlin MM, Cieslinski LB, Burman M; et al. (1993). "A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA". J. Biol. Chem. 268 (9): 6470–6. PMID 8384210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Obernolte R, Bhakta S, Alvarez R; et al. (1993). "The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family". Gene. 129 (2): 239–47. PMID 8392015.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bolger G, Michaeli T, Martins T; et al. (1993). "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs". Mol. Cell. Biol. 13 (10): 6558–71. PMID 8413254.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huston E, Lumb S, Russell A; et al. (1998). "Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3". Biochem. J. 328 ( Pt 2): 549–58. PMID 9371714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ma D, Wu P, Egan RW; et al. (1999). "Phosphodiesterase 4B gene transcription is activated by lipopolysaccharide and inhibited by interleukin-10 in human monocytes". Mol. Pharmacol. 55 (1): 50–7. PMID 9882697.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Secchiero P, Zella D, Curreli S; et al. (2001). "Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14620–5. doi:10.1073/pnas.011512398. PMID 11114167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zauli G, Milani D, Mirandola P; et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moon E, Lee R, Near R; et al. (2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia". Clin. Cancer Res. 8 (2): 589–95. PMID 11839681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shepherd M, McSorley T, Olsen AE; et al. (2003). "Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform". Biochem. J. 370 (Pt 2): 429–38. doi:10.1042/BJ20021082. PMID 12441002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arp J, Kirchhof MG, Baroja ML; et al. (2003). "Regulation of T-cell activation by phosphodiesterase 4B2 requires its dynamic redistribution during immunological synapse formation". Mol. Cell. Biol. 23 (22): 8042–57. PMID 14585965.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith PG, Wang F, Wilkinson KN; et al. (2005). "The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma". Blood. 105 (1): 308–16. doi:10.1182/blood-2004-01-0240. PMID 15331441.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Millar JK, Pickard BS, Mackie S; et al. (2005). "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling". Science. 310 (5751): 1187–91. doi:10.1126/science.1112915. PMID 16293762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)