PDCD1LG2: Difference between revisions

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{{Infobox_gene}}
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'''Programmed cell death 1 ligand 2''' (also known as PD-L2, B7-DC) is a [[protein]] that in humans is encoded by the ''PDCD1LG2'' [[gene]].<ref name="pmid11224527">{{cite journal | vauthors = Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ | title = PD-L2 is a second ligand for PD-1 and inhibits T cell activation | journal = Nat Immunol | volume = 2 | issue = 3 | pages = 261–8 |date=Mar 2001 | pmid = 11224527 | pmc =  | doi = 10.1038/85330 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80380| accessdate = }}</ref> PDCD1LG2 has also been designated as '''CD273''' ([[cluster of differentiation]] 273).
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Programmed cell death 1 ligand 2
| HGNCid = 18731
| Symbol = PDCD1LG2
| AltSymbols =; B7DC; Btdc; CD273; MGC142238; MGC142240; PD-L2; PDCD1L2; PDL2; bA574F11.2
| OMIM = 605723
| ECnumber = 
| Homologene = 10973
| MGIid = 1930125
| GeneAtlas_image1 = PBB_GE_PDCD1LG2_220049_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0042130 |text = negative regulation of T cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 80380
    | Hs_Ensembl = ENSG00000197646
    | Hs_RefseqProtein = NP_079515
    | Hs_RefseqmRNA = NM_025239
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 5500570
    | Hs_GenLoc_end = 5561252
    | Hs_Uniprot = Q9BQ51
    | Mm_EntrezGene = 58205
    | Mm_Ensembl = ENSMUSG00000016498
    | Mm_RefseqmRNA = XM_993457
    | Mm_RefseqProtein = XP_998551
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 29476955
    | Mm_GenLoc_end = 29537158
    | Mm_Uniprot = Q3U304
  }}
}}
'''Programmed cell death 1 ligand 2''', also known as '''PDCD1LG2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80380| accessdate = }}</ref> PDCD1LG2 has also been designated as '''CD273''' ([[cluster of differentiation]] 273).
 
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Latchman Y, Wood CR, Chernova T, ''et al.'' |title=PD-L2 is a second ligand for PD-1 and inhibits T cell activation. |journal=Nat. Immunol. |volume=2 |issue= 3 |pages= 261-8 |year= 2001 |pmid= 11224527 |doi= 10.1038/85330 }}
*{{cite journal   |vauthors=Tseng SY, Otsuji M, Gorski K, etal |title=B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. |journal=J. Exp. Med. |volume=193 |issue= 7 |pages= 839–46 |year= 2001 |pmid= 11283156 |doi=10.1084/jem.193.7.839  | pmc=2193370 }}
*{{cite journal  | author=Tseng SY, Otsuji M, Gorski K, ''et al.'' |title=B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. |journal=J. Exp. Med. |volume=193 |issue= 7 |pages= 839-46 |year= 2001 |pmid= 11283156 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Brown JA, Dorfman DM, Ma FR, etal |title=Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. |journal=J. Immunol. |volume=170 |issue= 3 |pages= 1257–66 |year= 2003 |pmid= 12538684 |doi=  10.4049/jimmunol.170.3.1257}}
*{{cite journal | author=Brown JA, Dorfman DM, Ma FR, ''et al.'' |title=Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. |journal=J. Immunol. |volume=170 |issue= 3 |pages= 1257-66 |year= 2003 |pmid= 12538684 |doi=  }}
*{{cite journal   |vauthors=Youngnak P, Kozono Y, Kozono H, etal |title=Differential binding properties of B7-H1 and B7-DC to programmed death-1. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 3 |pages= 672–7 |year= 2003 |pmid= 12893276 |doi=10.1016/S0006-291X(03)01257-9 }}
*{{cite journal | author=Youngnak P, Kozono Y, Kozono H, ''et al.'' |title=Differential binding properties of B7-H1 and B7-DC to programmed death-1. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 3 |pages= 672-7 |year= 2003 |pmid= 12893276 |doi=  }}
*{{cite journal   |vauthors=Tsushima F, Iwai H, Otsuki N, etal |title=Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. |journal=Eur. J. Immunol. |volume=33 |issue= 10 |pages= 2773–82 |year= 2003 |pmid= 14515261 |doi= 10.1002/eji.200324084 }}
*{{cite journal | author=Tsushima F, Iwai H, Otsuki N, ''et al.'' |title=Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. |journal=Eur. J. Immunol. |volume=33 |issue= 10 |pages= 2773-82 |year= 2003 |pmid= 14515261 |doi= 10.1002/eji.200324084 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Aramaki O, Shirasugi N, Takayama T, etal |title=Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen. |journal=Transplantation |volume=77 |issue= 1 |pages= 6–12 |year= 2004 |pmid= 14724428 |doi= 10.1097/01.TP.0000108637.65091.4B }}
*{{cite journal | author=Aramaki O, Shirasugi N, Takayama T, ''et al.'' |title=Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen. |journal=Transplantation |volume=77 |issue= 1 |pages= 6-12 |year= 2004 |pmid= 14724428 |doi= 10.1097/01.TP.0000108637.65091.4B }}
*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal  | vauthors=He XH, Liu Y, Xu LH, Zeng YY |title=Cloning and identification of two novel splice variants of human PD-L2. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=36 |issue= 4 |pages= 284–9 |year= 2004 |pmid= 15253154 |doi=10.1093/abbs/36.4.284 }}
*{{cite journal  | author=He XH, Liu Y, Xu LH, Zeng YY |title=Cloning and identification of two novel splice variants of human PD-L2. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=36 |issue= 4 |pages= 284-9 |year= 2004 |pmid= 15253154 |doi=  }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Ohigashi Y, Sho M, Yamada Y, etal |title=Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 8 |pages= 2947–53 |year= 2005 |pmid= 15837746 |doi= 10.1158/1078-0432.CCR-04-1469 }}
*{{cite journal | author=Ohigashi Y, Sho M, Yamada Y, ''et al.'' |title=Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 8 |pages= 2947-53 |year= 2005 |pmid= 15837746 |doi= 10.1158/1078-0432.CCR-04-1469 }}
*{{cite journal  | vauthors=Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML |title=PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion. |journal=Eur. J. Immunol. |volume=35 |issue= 12 |pages= 3561–9 |year= 2006 |pmid= 16278812 |doi= 10.1002/eji.200526347 }}
*{{cite journal  | author=Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML |title=PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion. |journal=Eur. J. Immunol. |volume=35 |issue= 12 |pages= 3561-9 |year= 2006 |pmid= 16278812 |doi= 10.1002/eji.200526347 }}
*{{cite journal   |vauthors=Pfistershammer K, Klauser C, Pickl WF, etal |title=No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. |journal=Eur. J. Immunol. |volume=36 |issue= 5 |pages= 1104–13 |year= 2006 |pmid= 16598819 | pmc=2975063 |doi= 10.1002/eji.200535344 }}
*{{cite journal | author=Pfistershammer K, Klauser C, Pickl WF, ''et al.'' |title=No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. |journal=Eur. J. Immunol. |volume=36 |issue= 5 |pages= 1104-13 |year= 2006 |pmid= 16598819 |doi= 10.1002/eji.200535344 }}
*{{cite journal   |vauthors=Abelson AK, Johansson CM, Kozyrev SV, etal |title=No evidence of association between genetic variants of the PDCD1 ligands and SLE. |journal=Genes Immun. |volume=8 |issue= 1 |pages= 69–74 |year= 2007 |pmid= 17136123 |doi= 10.1038/sj.gene.6364360 }}
*{{cite journal | author=Abelson AK, Johansson CM, Kozyrev SV, ''et al.'' |title=No evidence of association between genetic variants of the PDCD1 ligands and SLE. |journal=Genes Immun. |volume=8 |issue= 1 |pages= 69-74 |year= 2007 |pmid= 17136123 |doi= 10.1038/sj.gene.6364360 }}
*{{cite journal   |vauthors=Mataki N, Kikuchi K, Kawai T, etal |title=Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases. |journal=Am. J. Gastroenterol. |volume=102 |issue= 2 |pages= 302–12 |year= 2007 |pmid= 17311651 |doi= 10.1111/j.1572-0241.2006.00948.x }}
*{{cite journal | author=Mataki N, Kikuchi K, Kawai T, ''et al.'' |title=Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases. |journal=Am. J. Gastroenterol. |volume=102 |issue= 2 |pages= 302-12 |year= 2007 |pmid= 17311651 |doi= 10.1111/j.1572-0241.2006.00948.x }}
*{{cite journal   |vauthors=Wang SC, Lin CH, Ou TT, etal |title=Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus. |journal=J. Rheumatol. |volume=34 |issue= 4 |pages= 721–5 |year= 2007 |pmid= 17343323 |doi=10.1093/rheumatology/34.8.721 }}
*{{cite journal | author=Wang SC, Lin CH, Ou TT, ''et al.'' |title=Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus. |journal=J. Rheumatol. |volume=34 |issue= 4 |pages= 721-5 |year= 2007 |pmid= 17343323 |doi=  }}
}}
}}
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* {{MeshName|PDCD1LG2+protein,+human}}
* {{MeshName|PDCD1LG2+protein,+human}}


{{membrane-protein-stub}}
{{B7 family}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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{{membrane-protein-stub}}

Latest revision as of 17:48, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene.[1][2] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273).


References

  1. ↑ Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ (Mar 2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation". Nat Immunol. 2 (3): 261–8. doi:10.1038/85330. PMID 11224527.
  2. ↑ "Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2".

Further reading

External links

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