PARD6A

Par-6 partitioning defective 6 homolog alpha (C. elegans)
File:PBB Protein PARD6A image.jpg PDB rendering based on 1wmh.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wmh​
Identifiers
Symbols	PARD6A ; PAR-6A; PAR6; PAR6C; PAR6alpha; TAX40; TIP-40
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9661
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PARD6A 205245 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Par-6 partitioning defective 6 homolog alpha (C. elegans), also known as PARD6A, is a human gene.

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Solecki DJ, Govek EE, Hatten ME (2006). "mPar6 alpha controls neuronal migration". J. Neurosci. 26 (42): 10624–5. doi:10.1523/JNEUROSCI.4060-06.2006. PMID 17050699.CS1 maint: Multiple names: authors list (link)
• Rousset R, Fabre S, Desbois C; et al. (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene. 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qiu RG, Abo A, Steven Martin G (2000). "A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation". Curr. Biol. 10 (12): 697–707. PMID 10873802.CS1 maint: Multiple names: authors list (link)
• Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474.CS1 maint: Multiple names: authors list (link)
• Johansson A, Driessens M, Aspenström P (2000). "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1". J. Cell. Sci. 113 ( Pt 18): 3267–75. PMID 10954424.CS1 maint: Multiple names: authors list (link)
• Suzuki A, Yamanaka T, Hirose T; et al. (2001). "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures". J. Cell Biol. 152 (6): 1183–96. PMID 11257119.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Noda Y, Takeya R, Ohno S; et al. (2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.". Genes Cells. 6 (2): 107–19. PMID 11260256.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kohjima M, Noda Y, Takeya R; et al. (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. PMID 12459187.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hurd TW, Gao L, Roh MH; et al. (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brajenovic M, Joberty G, Küster B; et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lemmers C, Michel D, Lane-Guermonprez L; et al. (2004). "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells". Mol. Biol. Cell. 15 (3): 1324–33. doi:10.1091/mbc.E03-04-0235. PMID 14718572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weyrich P, Kapp K, Niederfellner G; et al. (2005). "Partitioning-defective protein 6 regulates insulin-dependent glycogen synthesis via atypical protein kinase C.". Mol. Endocrinol. 18 (5): 1287–300. doi:10.1210/me.2003-0253. PMID 14976222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu XF, Ishida H, Raziuddin R, Miki T (2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMID 15254234.CS1 maint: Multiple names: authors list (link)
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirano Y, Yoshinaga S, Takeya R; et al. (2005). "Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains". J. Biol. Chem. 280 (10): 9653–61. doi:10.1074/jbc.M409823200. PMID 15590654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weyrich P, Lammers R, Fritsche A; et al. (2005). "A novel functional polymorphism (-336A/G) in the promoter of the partitioning-defective protein-6alpha gene is associated with increased glucose tolerance and lower concentrations of serum non-esterified fatty acids". Diabetologia. 48 (4): 669–74. doi:10.1007/s00125-005-1688-4. PMID 15744531.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ozdamar B, Bose R, Barrios-Rodiles M; et al. (2005). "Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity". Science. 307 (5715): 1603–9. doi:10.1126/science.1105718. PMID 15761148.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)