Ovarian germ cell tumor medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overview

The mainstay of therapy for ovarian germ cell tumor is chemotherapy.[1][2][3][4]

Medical Therapy

Stage I ovarian germ cell tumors

  • Standard treatment options:
  • Dysgerminomas
  • Unilateral salpingo-oophorectomy with adjuvant radiation therapy or chemotherapy
  • Other germ cell tumors
  • Unilateral salpingo-oophorectomy with adjuvant chemotherapy


Stage II ovarian germ cell tumors

  • Standard treatment options:
  • Dysgerminomas
  • Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant radiation therapy or chemotherapy
  • Unilateral salpingo-oophorectomy with adjuvant chemotherapy
  • Other germ cell tumors
  • Unilateral salpingo-oophorectomy with adjuvant chemotherapy


Stage III ovarian germ cell tumors

  • Standard treatment options:
  • Dysgerminomas
  • Unilateral salpingo-oophorectomy with adjuvant chemotherapy
  • Other germ cell tumors
  • Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy, with or without neoadjuvant chemotherapy
  • Unilateral salpingo-oophorectomy with adjuvant chemotherapy, with or without neoadjuvant chemotherapy

Stage IV ovarian germ cell tumors

  • Standard treatment options:
  • Dysgerminomas
  • Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy
  • Unilateral salpingo-oophorectomy with adjuvant chemotherapy
  • Other germ cell tumors
  • Total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy with or without neoadjuvant chemotherapy
  • Unilateral salpingo-oophorectomy with adjuvant chemotherapy with or without neoadjuvant chemotherapy

References

  1. Stage I Ovarian Germ Cell Tumors . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_33. URL Accessed on Nov 5, 2015
  2. Stage II Ovarian Germ Cell Tumors . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_43. URL Accessed on Nov 5, 2015
  3. Stage III Ovarian Germ Cell Tumors . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_54. URL Accessed on Nov 5, 2015
  4. Stage IV Ovarian Germ Cell Tumors . http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_65. URL Accessed on Nov 5, 2015

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