Difference between revisions of "Ovarian cancer laboratory findings"

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==Overview==
 
==Overview==
The evaluation includes [[laboratory]] work, [[imaging]] and [[surgical]] exploration for the definite [[diagnosis]].  
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The evaluation includes [[laboratory]] work, [[imaging]] and [[surgical]] exploration for the definite [[diagnosis]]. Routine lab work includes CBC and CMP, Serum biomarkers of of [[epithelial ovarian cancer]] includes [[CA125]], HE4, OVA1. Serum biomarkers of the germ cell and sex cord-stromal ovarian cancer include [[alpha-fetoprotein]], [[human chorionic gonadotropin]], [[lactate dehydrogenase]], [[estradiol]], [[Inhibin]], [[testosterone]], [[androstenedione]], dehydroepiandrostenedione, [[anti-Müllerian hormone]].  
 
 
Routine lab work includes CBC and CMP, Serum biomarkers of of [[epithelial ovarian cancer]] includes [[CA125]], HE4, OVA1. Serum biomarkers of the germ cell and sex cord-stromal ovarian cancer include [[alpha-fetoprotein]], [[human chorionic gonadotropin]], [[lactate dehydrogenase]], [[estradiol]], [[Inhibin]], [[testosterone]], [[androstenedione]], dehydroepiandrostenedione, [[anti-Müllerian hormone]].  
 
 
==Laboratory finding==
 
==Laboratory finding==
  
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**[[CBC|complete blood count (CBC]])
 
**[[CBC|complete blood count (CBC]])
 
**Complete metabolic panel (CMP)
 
**Complete metabolic panel (CMP)
*Serum [[biomarkers]] of [[epithelial ovarian cancer]] (EOC):<ref name="pmid11369781">{{cite journal| author=Yin BW, Lloyd KO| title=Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. | journal=J Biol Chem | year= 2001 | volume= 276 | issue= 29 | pages= 27371-5 | pmid=11369781 | doi=10.1074/jbc.M103554200 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11369781  }} </ref>
+
*Serum [[biomarkers]] of [[epithelial ovarian cancer]] (EOC):<ref name="pmid11369781">{{cite journal| author=Yin BW, Lloyd KO| title=Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. | journal=J Biol Chem | year= 2001 | volume= 276 | issue= 29 | pages= 27371-5 | pmid=11369781 | doi=10.1074/jbc.M103554200 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11369781 }} </ref><ref name="pmid15781627">{{cite journal| author=Drapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR et al.| title=Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. | journal=Cancer Res | year= 2005 | volume= 65 | issue= 6 | pages= 2162-9 | pmid=15781627 | doi=10.1158/0008-5472.CAN-04-3924 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15781627  }} </ref><ref name="pmid6310399">{{cite journal| author=Bast RC, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H et al.| title=A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. | journal=N Engl J Med | year= 1983 | volume= 309 | issue= 15 | pages= 883-7 | pmid=6310399 | doi=10.1056/NEJM198310133091503 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6310399  }} </ref><ref name="pmid2651469">{{cite journal| author=Jacobs I, Bast RC| title=The CA 125 tumour-associated antigen: a review of the literature. | journal=Hum Reprod | year= 1989 | volume= 4 | issue= 1 | pages= 1-12 | pmid=2651469 | doi=10.1093/oxfordjournals.humrep.a136832 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2651469  }} </ref><ref name="pmid15313933">{{cite journal| author=Zhang Z, Bast RC, Yu Y, Li J, Sokoll LJ, Rai AJ et al.| title=Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. | journal=Cancer Res | year= 2004 | volume= 64 | issue= 16 | pages= 5882-90 | pmid=15313933 | doi=10.1158/0008-5472.CAN-04-0746 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313933 }} </ref>
 
**[[CA125]]
 
**[[CA125]]
 
*** Considered the best for [[ovarian cancer]] detection, [[therapeutic]] monitoring, and detection of the tumor recurrence
 
*** Considered the best for [[ovarian cancer]] detection, [[therapeutic]] monitoring, and detection of the tumor recurrence
 
***[[Postmenopausal]] woman: should be measured
 
***[[Postmenopausal]] woman: should be measured
 
***[[Premenopausal]] woman: should be measured only if [[ultrasonogram]] shows highly suspicious malignant mass
 
***[[Premenopausal]] woman: should be measured only if [[ultrasonogram]] shows highly suspicious malignant mass
** HE4 <ref name="pmid15781627">{{cite journal| author=Drapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR et al.| title=Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. | journal=Cancer Res | year= 2005 | volume= 65 | issue= 6 | pages= 2162-9 | pmid=15781627 | doi=10.1158/0008-5472.CAN-04-3924 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15781627  }} </ref>
+
** HE4  
 
***[[CA125]] and HE4 are used together to increase the [[sensitivity]] and [[specificity]] of [[ovarian cancer]] detection
 
***[[CA125]] and HE4 are used together to increase the [[sensitivity]] and [[specificity]] of [[ovarian cancer]] detection
 
***Risk of Ovarian Malignancy Algorithm ([[ROMA]]) is used to decide if the patient has a high risk or low-risk [[malignant]] disease based on:
 
***Risk of Ovarian Malignancy Algorithm ([[ROMA]]) is used to decide if the patient has a high risk or low-risk [[malignant]] disease based on:
 
****[[CA125]] and HE4 levels
 
****[[CA125]] and HE4 levels
 
****[[Menopausal]] status of the woman
 
****[[Menopausal]] status of the woman
** OVA1<ref name="pmid6310399">{{cite journal| author=Bast RC, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H et al.| title=A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. | journal=N Engl J Med | year= 1983 | volume= 309 | issue= 15 | pages= 883-7 | pmid=6310399 | doi=10.1056/NEJM198310133091503 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6310399  }} </ref><ref name="pmid2651469">{{cite journal| author=Jacobs I, Bast RC| title=The CA 125 tumour-associated antigen: a review of the literature. | journal=Hum Reprod | year= 1989 | volume= 4 | issue= 1 | pages= 1-12 | pmid=2651469 | doi=10.1093/oxfordjournals.humrep.a136832 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2651469  }} </ref><ref name="pmid15313933">{{cite journal| author=Zhang Z, Bast RC, Yu Y, Li J, Sokoll LJ, Rai AJ et al.| title=Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. | journal=Cancer Res | year= 2004 | volume= 64 | issue= 16 | pages= 5882-90 | pmid=15313933 | doi=10.1158/0008-5472.CAN-04-0746 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313933  }} </ref>
+
** OVA1
 
***  
 
***  
*Serum [[biomarkers]] of the [[germ cell]] and [[Sexcord/ stromal ovarian tumors|sex cord-stromal]] [[ovarian cancer]]:
+
*Serum [[biomarkers]] of the [[germ cell]] and [[Sexcord/ stromal ovarian tumors|sex cord-stromal]] [[ovarian cancer]]:<ref name="JashnaniHegde2013">{{cite journal|last1=Jashnani|first1=KusumD|last2=Hegde|first2=ChandrashekarV|last3=Munot|first3=ShrutikaP|title=Alfa-fetoprotein secreting ovarian sex cord-stromal tumor|journal=Indian Journal of Pathology and Microbiology|volume=56|issue=1|year=2013|pages=54|issn=0377-4929|doi=10.4103/0377-4929.116152}}</ref>
 
**AFP: [[alpha-fetoprotein]]
 
**AFP: [[alpha-fetoprotein]]
 
**hCG: [[human chorionic gonadotropin]]
 
**hCG: [[human chorionic gonadotropin]]
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**AMH: [[anti-Müllerian hormone]]
 
**AMH: [[anti-Müllerian hormone]]
  
*The gene for [[CA125]] was cloned in 2001 and is called MUC16<ref name="pmid11369781">{{cite journal| author=Yin BW, Lloyd KO| title=Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. | journal=J Biol Chem | year= 2001 | volume= 276 | issue= 29 | pages= 27371-5 | pmid=11369781 | doi=10.1074/jbc.M103554200 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11369781  }} </ref>
+
*The gene for [[CA125]] was cloned in 2001 and is called MUC16.<ref name="pmid11369781">{{cite journal| author=Yin BW, Lloyd KO| title=Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. | journal=J Biol Chem | year= 2001 | volume= 276 | issue= 29 | pages= 27371-5 | pmid=11369781 | doi=10.1074/jbc.M103554200 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11369781  }} </ref>
*[[Radioimmunoassay]] using a [[monoclonal antibody]] to monitor the course of [[epithelial ovarian cancer]]<ref name="pmid6310399">{{cite journal| author=Bast RC, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H et al.| title=A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. | journal=N Engl J Med | year= 1983 | volume= 309 | issue= 15 | pages= 883-7 | pmid=6310399 | doi=10.1056/NEJM198310133091503 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6310399  }} </ref>
+
*[[Radioimmunoassay]] using a [[monoclonal antibody]] to monitor the course of [[epithelial ovarian cancer]].<ref name="pmid6310399">{{cite journal| author=Bast RC, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H et al.| title=A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. | journal=N Engl J Med | year= 1983 | volume= 309 | issue= 15 | pages= 883-7 | pmid=6310399 | doi=10.1056/NEJM198310133091503 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6310399  }} </ref>
*[[CA125]] and the second generation test (CA125 II) are both clinically equivalent<ref name="pmidPMID 16690492">{{cite journal| author=Mongia SK, Rawlins ML, Owen WE, Roberts WL| title=Performance characteristics of seven automated CA 125 assays. | journal=Am J Clin Pathol | year= 2006 | volume= 125 | issue= 6 | pages= 921-7 | pmid=PMID 16690492 | doi=10.1309/NBA3-12W0-LANR-XYH9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16690492  }} </ref>
+
*[[CA125]] and the second generation test (CA125 II) are both clinically equivalent.<ref name="pmidPMID 16690492">{{cite journal| author=Mongia SK, Rawlins ML, Owen WE, Roberts WL| title=Performance characteristics of seven automated CA 125 assays. | journal=Am J Clin Pathol | year= 2006 | volume= 125 | issue= 6 | pages= 921-7 | pmid=PMID 16690492 | doi=10.1309/NBA3-12W0-LANR-XYH9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16690492  }} </ref>
  
  

Latest revision as of 15:19, 13 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Huda A. Karman, M.D.


Overview

The evaluation includes laboratory work, imaging and surgical exploration for the definite diagnosis. Routine lab work includes CBC and CMP, Serum biomarkers of of epithelial ovarian cancer includes CA125, HE4, OVA1. Serum biomarkers of the germ cell and sex cord-stromal ovarian cancer include alpha-fetoprotein, human chorionic gonadotropin, lactate dehydrogenase, estradiol, Inhibin, testosterone, androstenedione, dehydroepiandrostenedione, anti-Müllerian hormone.

Laboratory finding


References

  1. 1.0 1.1 Yin BW, Lloyd KO (2001). "Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16". J Biol Chem. 276 (29): 27371–5. doi:10.1074/jbc.M103554200. PMID 11369781.
  2. Drapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR; et al. (2005). "Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas". Cancer Res. 65 (6): 2162–9. doi:10.1158/0008-5472.CAN-04-3924. PMID 15781627.
  3. 3.0 3.1 Bast RC, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H; et al. (1983). "A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer". N Engl J Med. 309 (15): 883–7. doi:10.1056/NEJM198310133091503. PMID 6310399.
  4. Jacobs I, Bast RC (1989). "The CA 125 tumour-associated antigen: a review of the literature". Hum Reprod. 4 (1): 1–12. doi:10.1093/oxfordjournals.humrep.a136832. PMID 2651469.
  5. Zhang Z, Bast RC, Yu Y, Li J, Sokoll LJ, Rai AJ; et al. (2004). "Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer". Cancer Res. 64 (16): 5882–90. doi:10.1158/0008-5472.CAN-04-0746. PMID 15313933.
  6. Jashnani, KusumD; Hegde, ChandrashekarV; Munot, ShrutikaP (2013). "Alfa-fetoprotein secreting ovarian sex cord-stromal tumor". Indian Journal of Pathology and Microbiology. 56 (1): 54. doi:10.4103/0377-4929.116152. ISSN 0377-4929.
  7. Mongia SK, Rawlins ML, Owen WE, Roberts WL (2006). "Performance characteristics of seven automated CA 125 assays". Am J Clin Pathol. 125 (6): 921–7. doi:10.1309/NBA3-12W0-LANR-XYH9. PMID 16690492 PMID 16690492 Check |pmid= value (help).

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