Outcome measures in SMA

Outcome measures in SMA
ICD-10	G12
ICD-9	335.0-335.1
OMIM	253300 253550 253400 271150
DiseasesDB	14093 Template:DiseasesDB2 Template:DiseasesDB2
MeSH	D009134

WikiDoc Resources for Outcome measures in SMA
Articles
Most recent articles on Outcome measures in SMA Most cited articles on Outcome measures in SMA Review articles on Outcome measures in SMA Articles on Outcome measures in SMA in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Outcome measures in SMA Images of Outcome measures in SMA Photos of Outcome measures in SMA Podcasts & MP3s on Outcome measures in SMA Videos on Outcome measures in SMA
Evidence Based Medicine
Cochrane Collaboration on Outcome measures in SMA Bandolier on Outcome measures in SMA TRIP on Outcome measures in SMA
Clinical Trials
Ongoing Trials on Outcome measures in SMA at Clinical Trials.gov Trial results on Outcome measures in SMA Clinical Trials on Outcome measures in SMA at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Outcome measures in SMA NICE Guidance on Outcome measures in SMA NHS PRODIGY Guidance FDA on Outcome measures in SMA CDC on Outcome measures in SMA
Books
Books on Outcome measures in SMA
News
Outcome measures in SMA in the news Be alerted to news on Outcome measures in SMA News trends on Outcome measures in SMA
Commentary
Blogs on Outcome measures in SMA
Definitions
Definitions of Outcome measures in SMA
Patient Resources / Community
Patient resources on Outcome measures in SMA Discussion groups on Outcome measures in SMA Patient Handouts on Outcome measures in SMA Directions to Hospitals Treating Outcome measures in SMA Risk calculators and risk factors for Outcome measures in SMA
Healthcare Provider Resources
Symptoms of Outcome measures in SMA Causes & Risk Factors for Outcome measures in SMA Diagnostic studies for Outcome measures in SMA Treatment of Outcome measures in SMA
Continuing Medical Education (CME)
CME Programs on Outcome measures in SMA
International
Outcome measures in SMA en Espanol Outcome measures in SMA en Francais
Business
Outcome measures in SMA in the Marketplace Patents on Outcome measures in SMA
Experimental / Informatics
List of terms related to Outcome measures in SMA

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

There is currently no cure for spinal muscular atrophy. There has been great interest in identifying agents that can increase the amount of full- length SMN protein by upregulating expression of the SMN2 gene. Many clinical trials are ongoing to find the most reliable outcome measures.

Several new outcome measures have shown encouraging results and helped in designing future clinical trials. Some of them currently used in clinical trials are as follows –

• Quantitative muscle ultrasound

• The Six-Minute Walk Test (6MWT) – In case of ambulatory SMA patients.

• 10 minute walk/run test

• The Hammersmith Motor Scale

• The Hammersmith Functional Motor Scale Expanded (HFMSE)

• Knee flexor strength test

• The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND)

• The Gross Motor Function Measurement

• Motor unit number estimation (MUNE)

• Compound motor action potential (CMAP) amplitude

• Serologic biomarkers (SMN mRNA and protein levels)