Osteosarcoma risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Common risk factors in the development of osteosarcoma are radiation to bones, alkylating antineoplastic agents, Paget disease, multiple hereditary osteochondromas, fibrous dysplasia, Bloom syndrome,Rothmund-Thomson syndrome, and Li-Fraumeni syndrome.
Risk Factors
Common risk factors in development of osteosarcoma are:
- Age and height: data suggest that the risk of osteosarcoma is highest during the teenage "growth spurt." Children with osteosarcoma are usually tall for their age
- Radiation to bones: people who were treated with radiation for another cancer have a higher risk of later developing post-radiation (after radiation) osteosarcoma
- Drugs: past treatment with anticancer drugs called alkylating antineoplastic agents
- Certain bone diseases:
- Paget disease of bone
- Multiple hereditary osteochondromas
- Fibrous dysplasia
- Enchondromtosis
- Inherited cancer syndromes: Genetic diseases that predispose to osteosarcoma are:[1]
References
- ↑ Osteosarcoma. Dr Amir Rezaee ◉ and Dr Frank Gaillard ◉ et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/osteosarcoma