Osteosarcoma differential diagnosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].
Overview
Osteosarcoma must be differentiated from other diseases such as: any type of bone lesions caused by infection and/or tumors.
Features such as the eccentric location of the tumor in the metaphyseal portion of the bone and the skeletal location help to distinguish osteosarcoma from Ewing sarcoma. Bone metastases from other primary tumours, less frequent in the young than in adult patients, should also be considered.
Differentiating Osteosarcoma from other Diseases
Osteosarcoma must be differentiated from:[1][2][3][4][5]
- Osteomyelitis
- Pediatric Osteomyelitis
- Rhabdomyosarcoma
- Pediatric Rhabdomyosarcoma
- Chondrosarcoma
- Metastases from other malignancies
- Fibrous dysplasia
- Giant cell tumors
- Ewing's sarcoma
- Malignant fibrous histiocytoma
- Lymphoma
- Osteoblastoma
- Aneurysmal bone cyst
- Fibrosarcoma
- Cortical desmoid
| Disease | Bone involvement | Bone pain | Fever | Fractures | Mechanism | ALK level | Diagnosis |
|---|---|---|---|---|---|---|---|
| Osteoblastoma | Single | Yes | No | Yes | Neoplasm | High | Radiology and biopsy |
| Osteosarcoma | Single | Yes | No | Yes | Neoplasm | Normal | Radiology and biopsy |
| Osteoid osteoma | Single | Yes | No | Yes | Neoplasm | High | Radiology and biopsy |
| Aneurysmal bone cyst | Single | Yes | No | No | Neoplasm | High | Radiology and biopsy |
| Stress fracture | Multiple | Yes | No | Yes | Stress | Normal | Radiology |
| Osteomyelitis | Single | Yes | Yes | No | Infection | Normal | Radiology and biopsy |
| Brodie's abscess | Single | Yes | Yes | No | Infection | Normal | Radiology and biopsy |
References
- ↑ Kim HJ, Chalmers PN, Morris CD (February 2010). "Pediatric osteogenic sarcoma". Curr. Opin. Pediatr. 22 (1): 61–6. doi:10.1097/MOP.0b013e328334581f. PMID 19915470.
- ↑ Moore DD, Luu HH (2014). "Osteosarcoma". Cancer Treat. Res. 162: 65–92. doi:10.1007/978-3-319-07323-1_4. PMID 25070231.
- ↑ Ilaslan H, Schils J, Nageotte W, Lietman SA, Sundaram M (March 2010). "Clinical presentation and imaging of bone and soft-tissue sarcomas". Cleve Clin J Med. 77 Suppl 1: S2–7. doi:10.3949/ccjm.77.s1.01. PMID 20179183.
- ↑ Wu PK, Chen WM, Lee OK, Chen CF, Huang CK, Chen TH (November 2010). "The prognosis for patients with osteosarcoma who have received prior manipulative therapy". J Bone Joint Surg Br. 92 (11): 1580–5. doi:10.1302/0301-620X.92B11.24706. PMID 21037356.
- ↑ Obiedat H, Alrabadi N, Sultan E, Al Shatti M, Zihlif M (July 2018). "The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients". BMC Med. Genet. 19 (1): 112. doi:10.1186/s12881-018-0627-4. PMC 6035436. PMID 29980176.