Osteosarcoma biopsy: Difference between revisions

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__NOTOC__
__NOTOC__
{{Osteosarcoma}}
{{Osteosarcoma}}
{{CMG}};{{AE}} {{PSK}}
{{CMG}}; {{AE}}[[User:DrMars|Mohammadmain Rezazadehsaatlou[2]]].
==Overview==
==Overview==
[[Biopsy]] of [[osteosarcoma]] is important for confirming the [[diagnosis]] and the determining histologic subtype. [[Biopsy]] may be performed [[percutaneously]] with either a [[Needle aspiration biopsy|fine-needle]], or wide-bore needle, or through a formal [[incision]].
==Biopsy==
==Biopsy==
*Biopsy of osteosarcoma is important for confirming the diagnosis and for determining histologic subtype.<ref>Osteosarcoma. surgwiki. http://www.surgwiki.com/wiki/Diseases_of_bone_and_joints#SURGERY_4 Accessed on September 24, 2015</ref>
*[[Biopsy]] of [[osteosarcoma]] is important for confirming the [[diagnosis]] and the determining [[Histology|histologic]] subtype.
*Biopsy may be performed percutaneously with fine- or wide-bore needles, or through a formal incision.
*[[Biopsy]] procedures include:<ref name="pmid25070231">{{cite journal |vauthors=Moore DD, Luu HH |title=Osteosarcoma |journal=Cancer Treat. Res. |volume=162 |issue= |pages=65–92 |date=2014 |pmid=25070231 |doi=10.1007/978-3-319-07323-1_4 |url=}}</ref><ref name="pmid20179183">{{cite journal |vauthors=Ilaslan H, Schils J, Nageotte W, Lietman SA, Sundaram M |title=Clinical presentation and imaging of bone and soft-tissue sarcomas |journal=Cleve Clin J Med |volume=77 Suppl 1 |issue= |pages=S2–7 |date=March 2010 |pmid=20179183 |doi=10.3949/ccjm.77.s1.01 |url=}}</ref><ref name="pmid21037356">{{cite journal |vauthors=Wu PK, Chen WM, Lee OK, Chen CF, Huang CK, Chen TH |title=The prognosis for patients with osteosarcoma who have received prior manipulative therapy |journal=J Bone Joint Surg Br |volume=92 |issue=11 |pages=1580–5 |date=November 2010 |pmid=21037356 |doi=10.1302/0301-620X.92B11.24706 |url=}}</ref><ref name="pmid29980176">{{cite journal |vauthors=Obiedat H, Alrabadi N, Sultan E, Al Shatti M, Zihlif M |title=The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients |journal=BMC Med. Genet. |volume=19 |issue=1 |pages=112 |date=July 2018 |pmid=29980176 |pmc=6035436 |doi=10.1186/s12881-018-0627-4 |url=}}</ref>  
*More invasive methods carry a higher risk of complications and contamination of tissue planes. Each year 30% of limbs are lost through inappropriate biopsy site and technique. In principle, biopsies should be performed at a tumor center by a specialist in tumor surgery.
**'''[[Needle biopsy]]'''
*Inappropriate alignment of the biopsy or inadvertent contamination of soft tissues can render subsequent limb-preserving reconstructive surgery impossible.
*** [[Percutaneously]] with either a [[Needle aspiration biopsy|fine-needle]], or a wide-bore needle
 
**'''Surgical biopsy'''
To view histopathologic characteristic features of all subtypes of osteosarcoma, click [[Osteosarcoma pathophysiology|'''here''']].
***Through a formal [[incision]]
*More [[invasive]] methods carry a higher risk of complications and contamination of tissue planes.  
*Each year 30% of patients lose their limbs through inappropriate [[biopsy]] site and technique.  
*In principle, [[Biopsy|biopsies]] should be performed at a tumor center by a specialist in tumor surgery.
*Inappropriate alignment of the [[biopsy]] or inadvertent contamination of [[soft tissue]]<nowiki/>s can render subsequent limb-preserving [[Reconstructive surgery|reconstructive]] surgery impossible.


==References==
==References==
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[[Category:Disease]]
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Latest revision as of 13:20, 17 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].

Overview

Biopsy of osteosarcoma is important for confirming the diagnosis and the determining histologic subtype. Biopsy may be performed percutaneously with either a fine-needle, or wide-bore needle, or through a formal incision.

Biopsy

References

  1. Moore DD, Luu HH (2014). "Osteosarcoma". Cancer Treat. Res. 162: 65–92. doi:10.1007/978-3-319-07323-1_4. PMID 25070231.
  2. Ilaslan H, Schils J, Nageotte W, Lietman SA, Sundaram M (March 2010). "Clinical presentation and imaging of bone and soft-tissue sarcomas". Cleve Clin J Med. 77 Suppl 1: S2–7. doi:10.3949/ccjm.77.s1.01. PMID 20179183.
  3. Wu PK, Chen WM, Lee OK, Chen CF, Huang CK, Chen TH (November 2010). "The prognosis for patients with osteosarcoma who have received prior manipulative therapy". J Bone Joint Surg Br. 92 (11): 1580–5. doi:10.1302/0301-620X.92B11.24706. PMID 21037356.
  4. Obiedat H, Alrabadi N, Sultan E, Al Shatti M, Zihlif M (July 2018). "The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients". BMC Med. Genet. 19 (1): 112. doi:10.1186/s12881-018-0627-4. PMC 6035436. PMID 29980176.

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