Osteosarcoma: Difference between revisions

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==Treatment==
==Treatment==
[[Osteosarcoma medical therapy|Medical therapy]] | [[Osteosarcoma surgery|Surgical options]] | [[Osteosarcoma primary prevention|Primary prevention]]  | [[Osteosarcoma secondary prevention|Secondary prevention]] | [[Osteosarcoma cost-effectiveness of therapy|Financial costs]] | [[Osteosarcoma future or investigational therapies|Future therapies]]
[[Osteosarcoma medical therapy|Medical therapy]] | [[Osteosarcoma surgery|Surgical options]] | [[Osteosarcoma primary prevention|Primary prevention]]  | [[Osteosarcoma secondary prevention|Secondary prevention]] | [[Osteosarcoma cost-effectiveness of therapy|Financial costs]] | [[Osteosarcoma future or investigational therapies|Future therapies]]
==Case Examples==
===Case #1===
====Clinical Summary====
This 14-year-old white male first experienced mild pain in the left knee after playing baseball, approximately two months prior to admission. The pain persisted in an intermittent fashion, and was described as being somewhat worse at night. Approximately two weeks prior to admission, the pain increased significantly and was accompanied by marked swelling and loss of considerable motion of the knee joint. These symptoms were accompanied by a history of decreased appetite, lethargy, and a 10-pound weight loss. On physical examination, the left knee was enlarged diffusely, firm, and non-tender. Following biopsy, the patient was subjected to surgical removal of the distal femur and knee with placement of a prosthetic knee joint and bone grafts.
====Autopsy Findings====
The distal diaphysis of the femur and adjacent soft tissues were involved in a 15 x 10 x 10-cm mass. The cut surface of the mass was fleshy white, with focal areas of hemorrhage.
====Pathological Findings====
[http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]
[[Image:Osteosarcoma case 001.jpg|left|thumb|300px|This is a photograph of the patient prior to surgery. Note the marked swelling of the knee.]]
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[[Image:Osteosarcoma case 002.jpg|left|thumb|300px|This is a radiograph showing the tumor in the distal femur.]]
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[[Image:Osteosarcoma case 003.jpg|left|thumb|300px|This is another view of the tumor in the distal femur.]]
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[[Image:Osteosarcoma case 004.jpg|left|thumb|300px|This is a gross photograph of the surgical specimen with tissue dissected away to demonstrate the tumor mass.]]
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[[Image:Osteosarcoma case 005.jpg|left|thumb|300px|These are cut sections of the distal femur containing the tumor. The periosteal involvement is evident from this picture (arrows).]]
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[[Image:Osteosarcoma case 006.jpg|left|thumb|300px|This is a low-power photomicrograph of decalcified histologic section from this tumor. Note the blue color (cell nuclei stain blue) of much of this section indicating the increased cellularity of the tumor.]]
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[[Image:Osteosarcoma case 007.jpg|left|thumb|300px|This is a higher-power photomicrograph of decalcified histologic section from this tumor. There are areas of osteoid (1) and cellular areas (2).]]
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[[Image:Osteosarcoma case 008.jpg|left|thumb|300px|This is a high-power photomicrograph of decalcified histologic section showing the cellularity of the tumor.]]
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[[Image:Osteosarcoma case 009.jpg|left|thumb|300px|This high-power photomicrograph demonstrates the cellular growth pattern. Note that the cells are fusiform and they grow in sheets.]]
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[[Image:Osteosarcoma case 010.jpg|left|thumb|300px|This high-power photomicrograph demonstrates the growth pattern and the cell morphology.]]
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[[Image:Osteosarcoma case 011.jpg|left|thumb|300px|This is a high-power photomicrograph of the tumor cell morphology and the periosteum (arrow).]]
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[[Image:Osteosarcoma case 012.jpg|left|thumb|300px|This high-power photomicrograph of the tumor demonstrates the fusiform morphology of the cells. Note the marked variability in size and staining intensity of the nuclei.]]
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[[Image:Osteosarcoma case 013.jpg|left|thumb|300px|This is a high-power photomicrograph of the tumor demonstrating the anaplastic cell morphology.]]
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[[Image:Osteosarcoma case 014.jpg|left|thumb|300px|This is a high-power photomicrograph of the tumor demonstrating the anaplastic cell morphology.]]
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[[Image:Osteosarcoma case 015.jpg|left|thumb|300px|This is a high-power photomicrograph of the tumor demonstrating the anaplastic cell morphology and multiple mitotic figures (arrows).]]
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==References==
==References==

Revision as of 15:00, 18 January 2012

Osteosarcoma
ICD-10 C40-C41
ICD-9 170
ICD-O: Template:ICDO
OMIM 259500
DiseasesDB 9392
MedlinePlus 001650
MeSH D012516

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [3] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Historical Perspective

Pathophysiology

Epidemiology & Demographics

Risk Factors

Screening

Causes

Differentiating Osteosarcoma

Complications & Prognosis

Diagnosis

History and Symptoms | Physical Examination | Staging | Laboratory tests | Electrocardiogram | X Rays | CT | MRI Echocardiography or Ultrasound | Other images | Alternative diagnostics

Treatment

Medical therapy | Surgical options | Primary prevention | Secondary prevention | Financial costs | Future therapies

References

Additional Resources

  • James, H. (1979). Promises in the Dark. New York: Bantam Books. ISBN 0-553-13453-1. Story of a young girl's osteosarcoma fight and its effect on her relationship with her boyfriend
  • Trottier, Maxine (2005). Terry Fox: A Story of Hope. Markham, Ont: Scholastic Canada. ISBN 0-439-94888-6. About Terry Fox and his quest to raise $25 million for cancer research by running across Canada on his prosthetic leg. Also The Terry Fox Story, a 1983 movie.
  • Belshaw, Sheila M. (2001). Fly With a Miracle. Denor Press. ISBN 0 9526056 7 8.

External links

Acknowledgements

The content on this page was first contributed by: C. Michael Gibson M.S., M.D.

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