Noncompaction cardiomyopathy histology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There is no pathognomonic finding on biopsy, although the majority of studies indicate that fibrosis is frequently present[1][2][3].

Histologic Differences Between Isolated Noncompaction Cardiomyopathy and that Associated with Congenital Heart Disease

Among patients with isolated noncompaction, the deep intertrabecular recesses communicate with only the left ventricular cavity. In contrast, among patients with noncompaction associated with other congenital heart diseases, the deep intertrabecular recesses communicate with both the left ventricular cavity and the coronary circulation[4].

Findings on Biopsy

References

  1. Finsterer J, Stollberger C, Feichtinger H. Histological appearance of left ventricular hypertrabeculation/noncompaction. Cardiology. 2002; 98: 162–164.
  2. Conraads V, Paelinck B, Vorlat A, et al. Isolated non-compaction of the left ventricle: a rare indication for transplantation. J Heart Lung Transplant. 2001; 20: 904–907.
  3. Daimon Y, Watanabe S, Takeda S, et al. Two-layered appearance of noncompaction of the ventricular myocardium on magnetic resonance imaging.
  4. Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000; 36: 493–500.
  5. Hamamichi Y, Ichida F, Hashimoto I, et al. Isolated noncompaction of the ventricular myocardium: ultrafast computer tomography and magnetic resonance imaging. Int J Cardiovasc Imaging. 2001; 17: 305–314.
  6. Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000; 36: 493–500.
  7. Finsterer J, Stollberger C, Feichtinger H. Histological appearance of left ventricular hypertrabeculation/noncompaction. Cardiology. 2002; 98: 162–164.


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