Non small cell lung cancer classification: Difference between revisions

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Latest revision as of 22:58, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

Non-small cell lung cancer may be classified according to the WHO histological classification system into 3 main types; Squamous cell carcinoma, lung adenocarcinoma, and large cell carcinoma. Other less common subtypes include adenosquamous lung carcinoma, pulmonary sarcomatoid carcinoma, carcinoid tumor of the lung, and carcinomas of the lung of salivary gland type.

Classification

There are 3 main types of non–small cell lung cancer:^[1]^[2]^[3]
The table below summarizes the WHO histological classification system for non small cell lung cancer.^[4]

WHO histological classification system Adapted from WHO/IARC (2006)
Main types	Subtypes	Prevalence
Adenocarcinoma	Adenocarcinoma, mixed Acinar adenocarcinoma Papillary adenocarcinoma Bronchioloalveolar carcinoma Nonmucinous Mucinous Mixed nonmucinous and mucinous or indeterminate Solid adenocarcinoma with mucin production Fetal adenocarcinoma Mucinous (“colloid”) carcinoma Mucinous cystadenocarcinoma Signet ring adenocarcinoma Clear cell adenocarcinoma	40% of lung cancers
Squamous cell carcinoma	Papillary Clear cell Small cell Basaloid	25% of lung cancers
Large cell carcinoma	Large cell neuroendocrine carcinoma Basaloid carcinoma Lymphoepithelioma-like carcinoma Clear cell carcinoma Large cell carcinoma with rhabdoid phenotype	10% of lung cancer
Less common types
Adenosquamous carcinoma	No subtypes	Less than 5%
Sarcomatoid carcinoma	Pleomorphic carcinoma Spindle cell carcinoma Giant cell carcinoma Carcinosarcoma Pulmonary blastoma	Less than 5%
Carcinoid tumor	Typical carcinoid Atypical carcinoid	Less than 5%
Salivary gland tumor	Mucoepidermoid carcinoma Adenoid cystic carcinoma Epithelial-myoepithelial carcinoma	Less than 5%

References

↑ Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.
↑ Travis, William (2004). Pathology and genetics of tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press. ISBN 9283224183.
↑ Raz DJ, He B, Rosell R, Jablons DM (2006). "Bronchioloalveolar carcinoma: a review". Clin Lung Cancer. 7 (5): 313–22. doi:10.3816/CLC.2006.n.012. PMID 16640802.
↑ Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016

[NSCLC-1] Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.

[2] Travis, William (2004). Pathology and genetics of tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press. ISBN 9283224183.

[pmid16640802-3] Raz DJ, He B, Rosell R, Jablons DM (2006). "Bronchioloalveolar carcinoma: a review". Clin Lung Cancer. 7 (5): 313–22. doi:10.3816/CLC.2006.n.012. PMID 16640802.

[radiowiki-4] Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016

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@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Non small cell lung cancer}}
-{{CMG}}; {{AE}} {{SC}}
+{{CMG}}; {{AE}} {{SC}} {{MV}}
 ==Overview==
+Non-small cell lung cancer may be classified according to the [[World Health Organization|WHO histological classification system]] into 3 main types; [[Squamous cell lung cancer|Squamous cell carcinoma]], [[Adenocarcinoma of the lung|lung adenocarcinoma]], and [[Large cell carcinoma of the lung|large cell carcinoma]]. Other less common subtypes include adenosquamous lung carcinoma, [[Sarcomatoid carcinoma of the lung|pulmonary sarcomatoid carcinoma]], [[carcinoid tumor of the lung]], and carcinomas of the lung of salivary gland type.
 ==Classification==
-* The most common type of lung cancer is non–small cell lung cancer (NSCLC). About 85%–90% of all lung cancers are non–small cell lung cancer. The other 10%–15% are small cell lung cancer.
+* There are 3 main types of non–small cell lung cancer:<ref name="NSCLC">Non-Small Cell Lung Cancer Treatment –for health professionals. National Cancer Institute – Physician Data Query PDQ. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq#link/_361_toc Accessed on February 3, 2016.</ref><ref>{{cite book | last = Travis | first = William | title = Pathology and genetics of tumours of the lung, pleura, thymus, and heart | publisher = IARC Press | location = Lyon | year = 2004 | isbn = 9283224183 }}</ref><ref name="pmid16640802">{{cite journal| author=Raz DJ, He B, Rosell R, Jablons DM| title=Bronchioloalveolar carcinoma: a review. | journal=Clin Lung Cancer | year= 2006 | volume= 7 | issue= 5 | pages= 313-22 | pmid=16640802 | doi=10.3816/CLC.2006.n.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16640802  }} </ref>
+** [[Adenocarcinoma of the lung|Adenocarcinoma]]
+** [[Squamous cell carcinoma of the lung|Squamous cell carcinoma]]
+** [[Large cell carcinoma of the lung|Large cell carcinoma]]
+*The table below summarizes the WHO histological classification system for non small cell lung cancer.<ref name="radiowiki">  Tumors of the Lung. IARC/WHO https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 22, 2016 </ref>
-* There are 3 main types of non–small cell lung cancer: adenocarcinoma, squamous cell carcinoma and large cell carcinoma.
+{|
+! colspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" + |WHO histological classification system<br>Adapted from WHO/IARC (2006)
-'''Subtypes'''
+|-
-* [[Adenocarcinoma of the lung|Adenocarcinoma]]
+! align="center" style="background:#4479BA; color: #FFFFFF;" + |Main types
+! align="center" style="background:#4479BA; color: #FFFFFF;" + |Subtypes
-:* Adenocarcinoma, mixed subtype
+! align="center" style="background:#4479BA; color: #FFFFFF;" + |Prevalence
+|-
-:* Acinar adenocarcinoma
+! align="center" style="background:#DCDCDC;" + |Adenocarcinoma
+| align="left" style="background:#F5F5F5;" + |
-:* Papillary adenocarcinoma
+*Adenocarcinoma, mixed
+*Acinar adenocarcinoma
-:* Bronchioloalveolar carcinoma
+*Papillary adenocarcinoma
+*Bronchioloalveolar carcinoma
-::* Nonmucinous
+*Nonmucinous
+*Mucinous
-::* Mucinous
+*Mixed nonmucinous and mucinous or indeterminate
+*Solid adenocarcinoma with mucin production
-::* Mixed nonmucinous and mucinous or indeterminate
+*Fetal adenocarcinoma
-:* Solid adenocarcinoma with mucin production
+*Mucinous (“colloid”) carcinoma
+*Mucinous cystadenocarcinoma
-::* Fetal adenocarcinoma
+*Signet ring adenocarcinoma
+*Clear cell adenocarcinoma
-::* Mucinous (“colloid”) carcinoma
+| align="center" style="background:#F5F5F5;" + |
+*40% of lung cancers
-::* Mucinous cystadenocarcinoma
+|-
+! align="center" style="background:#DCDCDC;" + |Squamous cell carcinoma
-::* Signet ring adenocarcinoma
+| align="left" style="background:#F5F5F5;" + |
+*Papillary
-::* Clear cell adenocarcinoma
+*Clear cell
+*Small cell
-* Squamous cell carcinoma
+*Basaloid
+| align="left" style="background:#F5F5F5;" + |
-:* Papillary
+*25% of lung cancers
+|-
-:* Clear cell
+! align="center" style="background:#DCDCDC;" + |Large cell carcinoma
+| align="left" style="background:#F5F5F5;" + |
-:* Small cell
+*Large cell neuroendocrine carcinoma
+*Basaloid carcinoma
-:* Basaloid
+*Lymphoepithelioma-like carcinoma
+*Clear cell carcinoma
-* Large cell carcinoma
+*Large cell carcinoma with rhabdoid phenotype
+| align="left" style="background:#F5F5F5;" + |
-:* Large cell neuroendocrine carcinoma
+*10% of lung cancer
+|-
-:* Basaloid carcinoma
+| colspan="3" style="background: #4479BA; width: 100px; text-align:center;" |{{fontcolor|#FFF|'''Less common types'''}}
+|-
-:* Lymphoepithelioma-like carcinoma
+! align="center" style="background:#DCDCDC;" + |Adenosquamous carcinoma
+| align="left" style="background:#F5F5F5;" + |
-:* Clear cell carcinoma
+*No subtypes
+| align="left" style="background:#F5F5F5;" + |
-:* Large cell carcinoma with rhabdoid phenotype
+*Less than 5%
-* Adenosquamous carcinoma
+|-
+! align="center" style="background:#DCDCDC;" + |Sarcomatoid carcinoma
-* Sarcomatoid carcinoma
+| align="left" style="background:#F5F5F5;" + |
+*Pleomorphic carcinoma
-:* Pleomorphic carcinoma
+*Spindle cell carcinoma
+*Giant cell carcinoma
-:* Spindle cell carcinoma
+*Carcinosarcoma
+*Pulmonary blastoma
-:* Giant cell carcinoma
+| align="left" style="background:#F5F5F5;" + |
+*Less than 5%
-:* Carcinosarcoma
+|-
+! align="center" style="background:#DCDCDC;" + |Carcinoid tumor
-:* Pulmonary blastoma
+| align="left" style="background:#F5F5F5;" + |
-* Carcinoid tumor
+*Typical carcinoid
+*Atypical carcinoid
-:* Typical carcinoid
+| align="left" style="background:#F5F5F5;" + |
+*Less than 5%
-:* Atypical carcinoid
+|-
-* Salivary gland tumor
+! align="center" style="background:#DCDCDC;" + |Salivary gland tumor
-:* Mucoepidermoid carcinoma
+| align="left" style="background:#F5F5F5;" + |
+*Mucoepidermoid carcinoma
-:* Adenoid cystic carcinoma
+*Adenoid cystic carcinoma
+*Epithelial-myoepithelial carcinoma
-:* Epithelial-myoepithelial carcinoma
+| align="left" style="background:#F5F5F5;" + |
+*Less than 5%
+|}
 ==References==
 {{reflist|2}}
-[[Category:Hematology]]
+[[Category:Medicine]]
-[[Category:Types of cancer]]
+[[Category:Pulmonology]]
-[[Category:Disease]]
+[[Category:Oncology]]
+[[Category:Up-To-Date]]
-{{WikiDoc Help Menu}}
-{{WikiDoc Sources}}

Non small cell lung cancer classification: Difference between revisions

Latest revision as of 22:58, 29 July 2020

Overview

Classification

References

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