Non-alcoholic fatty liver disease historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

NAFLD/NASH was first described as a medical entity in a 1980. Though its histological capabilities had lengthy been recognized , the time period non-alcoholic steatohepatitis (NASH) became first used by Ludwig et al. as recently as 1980 .Ludwig et al. described ‘‘the pathological and medical features of non-alcoholic disease of the liver related with the pathological features maximum generally seen inside the alcoholic liver disorder itself.

Historical Perspective

• In 1980, NAFLD was introduced as a new concept in medical history.
• The association between obesity and NAFLD was made during 1979 by Adler & Schaffner by extending the clinical picture of NASH.
• In an intensive literature seek of 41 papers.published before 1984, reporting on 1515 morbidly overweight sufferers, Andersen & Gluud reported excess fat in 80%,‘‘parenchymal necrosis’’ in 5–63%, fibrosis in 29% and cirrhosis in 3%.