Non-alcoholic fatty liver disease: Difference between revisions
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*Our understanding of NAFLD natural history is evolving with extensive research and we can classify NAFLD further by prospectively collecting the data with well defined and well designed studies. <ref name="pmid27003142">{{cite journal |vauthors=Goh GB, McCullough AJ |title=Natural History of Nonalcoholic Fatty Liver Disease |journal=Dig. Dis. Sci. |volume=61 |issue=5 |pages=1226–33 |year=2016 |pmid=27003142 |doi=10.1007/s10620-016-4095-4 |url=}}</ref> | *Our understanding of NAFLD natural history is evolving with extensive research and we can classify NAFLD further by prospectively collecting the data with well defined and well designed studies. <ref name="pmid27003142">{{cite journal |vauthors=Goh GB, McCullough AJ |title=Natural History of Nonalcoholic Fatty Liver Disease |journal=Dig. Dis. Sci. |volume=61 |issue=5 |pages=1226–33 |year=2016 |pmid=27003142 |doi=10.1007/s10620-016-4095-4 |url=}}</ref> | ||
*If left untreated, Patients with NAFLD may progress to develop NASH which is a more serious complication. | *If left untreated, Patients with NAFLD may progress to develop NASH which is a more serious complication. | ||
===Complications=== | ===Complications=== | ||
*Common complications of NAFLD include: <ref name="urlNonalcoholic Fatty Liver Disease Symptoms, Causes, and More">{{cite web |url=https://www.healthline.com/health/nonalcoholic-fatty-liver-disease#complications |title=Nonalcoholic Fatty Liver Disease Symptoms, Causes, and More |format= |work= |accessdate=}}</ref> | *Common complications of NAFLD include: <ref name="urlNonalcoholic Fatty Liver Disease Symptoms, Causes, and More">{{cite web |url=https://www.healthline.com/health/nonalcoholic-fatty-liver-disease#complications |title=Nonalcoholic Fatty Liver Disease Symptoms, Causes, and More |format= |work= |accessdate=}}</ref> | ||
Revision as of 13:35, 6 December 2017
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Non-Alcoholic Fatty Liver Disease Microchapters |
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Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases |
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Diagnosis |
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Treatment |
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Case studies |
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Non-alcoholic fatty liver disease On the Web |
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American Roentgen Ray Society Images of Non-alcoholic fatty liver disease |
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Directions to Hospitals Treating Non-alcoholic fatty liver disease |
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Risk calculators and risk factors for Non-alcoholic fatty liver disease |
Editor in Chief: Elliot Tapper, M.D., Beth Israel Deaconess Medical Center
For the patient information page on this topic, click here.
Synonyms and keywords: NASH, NAFLD, non alcoholic steatohepatitis
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Natural History
- The symptoms of NAFLD usually develop in the fourth decade of life.
- With the raising concern of obesity and metabolic syndrome NAFLD is becoming the most common liver disease in the world.
- Our understanding of NAFLD natural history is evolving with extensive research and we can classify NAFLD further by prospectively collecting the data with well defined and well designed studies. [1]
- If left untreated, Patients with NAFLD may progress to develop NASH which is a more serious complication.
Complications
- Common complications of NAFLD include: [2]
- NASH
- Cirrhosis
- Gastro intestinal bleeding
- Liver failure
- Liver cancer
Prognosis
- Prognosis is generally variable with NAFLD patients.
- Depending on the NAFLD Activity Score (NAS) of the NAFLD at the time of diagnosis, the prognosis may vary.
- The presence of fibrosis in NAFLD patients is associated with a particularly poor prognosis.[3]
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
External Links
- NIH page on Nonalcoholic Steatohepatitis
- ↑ Goh GB, McCullough AJ (2016). "Natural History of Nonalcoholic Fatty Liver Disease". Dig. Dis. Sci. 61 (5): 1226–33. doi:10.1007/s10620-016-4095-4. PMID 27003142.
- ↑ "Nonalcoholic Fatty Liver Disease Symptoms, Causes, and More".