Non-Hodgkin lymphoma classification: Difference between revisions

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| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Adult T-cell leukemia/lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Adult T-cell leukemia/lymphoma]]
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| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |µ heavy-chain disease  
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Heavy chain disease]]
 
* µ heavy-chain disease
ɣ heavy-chain disease  
* ɣ heavy-chain disease  
 
* α heavy-chain disease
α heavy-chain disease
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Extranodal T/NK-cell lymphoma, nasal type
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |Extranodal T/NK-cell lymphoma, nasal type
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| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Subcutaneous panniculitis-like T-cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Subcutaneous panniculitis-like T-cell lymphoma]]
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| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |<nowiki> style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | </nowiki>[[Nodal marginal zone B-cell lymphoma]] (± monocytoid B-cells)
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Nodal marginal zone B-cell lymphoma]] (± monocytoid B-cells)
pediatric [[Nodal marginal zone B-cell lymphoma]]  
pediatric
 
[[Nodal marginal zone B-cell lymphoma]]  
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Mycosis fungoides]]  
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Mycosis fungoides]]  
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| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Follicular lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Follicular lymphoma]]
In situ follicular neoplasia
* In situ follicular neoplasia
 
* Duodenal-type follicular lymphoma  
Duodenal-type follicular lymphoma  
* Pediatric-type follicular lymphoma  
 
Pediatric-type follicular lymphoma  


| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Sézary syndrome]]
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Sézary syndrome]]
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| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Intravascular large B-cell lymphoma]]  
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Intravascular large B-cell lymphoma]]  
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |
| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |
Hepatosplenic gamma / delta T-cell lymphoma
Hepatosplenic gamma / delta T-cell lymphoma
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Revision as of 20:38, 14 December 2018

Non-Hodgkin lymphoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Non-Hodgkin lymphoma may be classified into subtypes according to updated WHO classification and rate of growth.

Classification

A. Updated WHO classification

  • Non-Hodgkin lymphoma may be classified according to updated WHO classification into 2 groups:[1]
  • B-cell neoplasms
  • T-cell and putative NK-cell neoplasms
Updated WHO classification of Non-Hodgkin lymphoma
B-cell neoplasms T-cell and putative NK-cell neoplasms
Precursor B-cell neoplasm Precursor T-cell neoplasm
Precursor B-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL)
Mature B-cell neoplasms Peripheral T-cell and NK-cell neoplasms
Chronic lymphocytic leukemia / small lymphocytic lymphoma T-cell prolymphocytic leukemia
Monoclonal B-cell lymphocytosis T-cell granular lymphocytic leukemia
B-cell prolymphocytic leukemia Chronic lymphoproliferative disorder of NK cells
Splenic marginal zone lymphoma (± villous lymphocytes)

Splenic B-cell lymphoma/leukemia, unclassifiable

1. Splenic diffuse red pulp small B-cell lymphoma

2. Hairy cell leukemia-variant

Aggressive NK-cell leukemia
Hairy cell leukemia Systemic EBV positive T-cell lymphoma of childhood
Lymphoplasmacytic lymphoma

Waldenström's macroglubulinemia

Hydroa vacciniforme–like lymphoproliferative disorder
Monoclonal gammopathy of undetermined significance (MGUS),
  • IgM
  • IgG/A
Adult T-cell leukemia/lymphoma
Heavy chain disease
  • µ heavy-chain disease
  • ɣ heavy-chain disease
  • α heavy-chain disease
Extranodal T/NK-cell lymphoma, nasal type
Plasma cell myeloma (multiple myloma) Enteropathy-type intestinal T-cell lymphoma
Solitary plasmacytoma of bone Monomorphic epitheliotropic intestinal T-cell lymphoma
Extraosseous plasmacytoma Indolent T-cell lymphoproliferative disorder of the GI trac
Monoclonal immunoglobulin deposition diseases Hepatosplenic T-cell lymphoma
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) Subcutaneous panniculitis-like T-cell lymphoma
Nodal marginal zone B-cell lymphoma (± monocytoid B-cells)

pediatric

Nodal marginal zone B-cell lymphoma

Mycosis fungoides
Follicular lymphoma
  • In situ follicular neoplasia
  • Duodenal-type follicular lymphoma
  • Pediatric-type follicular lymphoma
Sézary syndrome
Large B-cell lymphoma with IRF4 rearrangement Primary cutaneous CD301 T-cell lymphoproliferative disorders Lymphomatoid papulosis Primary cutaneous anaplastic large cell lymphoma
Primary cutaneous follicle center lymphoma Primary cutaneous gamma delta T-cell lymphoma

Primary cutaneous CD8 aggressive epidermotropic cytotoxic T-cell lymphoma

Primary cutaneous acral CD8 T-cell lymphoma

Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder

Mantle cell lymphoma

In situ mantle cell neoplasia

Peripheral T-cell lymphoma, NOS *

Peripheral T-cell lymphoma, not otherwise characterized

Diffuse large B-cell lymphoma (DLBCL), NOS
  • Germinal center B-cell type
  • Activated B-cell type
  • Primary DLBCL of the central nervous system (CNS)
  • Primary cutaneous DLBCL, leg type
  • DLBCL associated with chronic inflammation
  • HHV81 DLBCL, NOS
Angioimmunoblastic T-cell lymphoma
T-cell/histiocyte-rich large B-cell lymphoma Follicular T-cell lymphoma
EBV1 DLBCL, NOS

EBV1 mucocutaneous ulcer

Nodal peripheral T-cell lymphoma with TFH phenotype

Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+)

Lymphomatoid granulomatosis Anaplastic large cell lymphoma
  • ALK positive
  • ALK negitive
Primary mediastinal (thymic) large B-cell lymphoma Breast implant–associated anaplastic large-cell lymphoma
Intravascular large B-cell lymphoma

Hepatosplenic gamma / delta T-cell lymphoma

ALK1 large B-cell lymphoma
Plasmablastic lymphoma
Primary effusion lymphoma
Burkitt lymphoma

Burkitt-like lymphoma with 11q aberration

High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements

High-grade B-cell lymphoma, NOS*

B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

B. Classification based on rate of growth

  • Non-Hodgkin lymphoma may be classified based on rate of growth into 2 groups:[2]
  • Low-grade or Indolent lymphoma
  • High-grade or Aggressive lymphoma
Non-Hodgkin lymphoma classification
Grade Description
Low-grade or Indolent lymphoma
  • Tend to grow very slowly
  • Tend to be widespread by the time they are diagnosed
  • Often involving the bone marrow and spleen
  • Often treated only when symptoms appear
  • Can shrink or seem to disappear with treatment, but they tend to come back
  • Can change into more aggressive lymphomas
  • Have a fairly good prognosis
High-grade or Aggressive lymphoma
  • Grow quickly and tend to spread to lymph nodes or other organs throughout the body
  • Cause symptoms and need treatment right away
  • Can frequently be successfully treated with intensive chemotherapy treatment
Non-Hodgkin's Lymphoma

References

  1. National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
  2. "Canadian Cancer Society Grades of non-Hodgkin lymphoma".

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