Nitroprusside: Difference between revisions

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__NOTOC__
{{DrugProjectFormSinglePage
{{Nitroprusside}}
|authorTag=
{{CMG}}; {{AE}} {{SS}}


'''''For patient information about Nitroprusside, click [[Nitroprusside (patient information)|here]].'''''


{{SB}} NITROPRESS<sup>®</sup>
<!--Overview-->


{|
|genericName=
|[[File:nitropress01.jpg|thumb|800px]]
|}


==Overview==


'''Sodium nitroprusside''' is an [[inorganic compound]] with the [[chemical formula|formula]] Na<sub>2</sub>[Fe(CN)<sub>5</sub>NO], usually encountered as the [[water of crystallization|dihydrate]], Na<sub>2</sub>[Fe(CN)<sub>5</sub>NO]·2H<sub>2</sub>O.<ref>{{cite journal| title=Non-Heme Iron Nitrosyls in Biology |author= A. R. Butler, I. L. Megson| journal=Chemical Reviews |year=2002|volume= 102| pages= 1155–1165| doi=10.1021/cr000076d| issue=4}}
|aOrAn=
</ref> This red-colored sodium salt dissolves in water ethanol to give solutions containing the free [[coordination complex|complex]] dianion [Fe(CN)<sub>5</sub>NO]<sup>2−</sup>.
a


This compound is used as a drug. In this role it is abbreviated '''SNP''', and it has tradenames like '''Nitropress'''. It acts as a drug by releasing [[Biological functions of nitric oxide|nitric oxide]]; it belongs to the class of [[NO-releasing drug]]s as a result. This drug is used as a [[vasodilator]] to reduce blood pressure. It has also been used to treat other conditions, and it has been successfully tried as treatment for [[schizophrenia]]. Sodium nitroprusside is also used as an analytical reagent for the detection of methyl ketones, and for the detection of amines that are often found in illicit drugs.
|drugClass=
==Category==


[[Cyanides]];[[Vasodilators]];[[Coordination compounds]];[[World Health Organization essential medicines]];[[Ironcompounds]];[[Nitrosylcompounds]];[[Cardiovascular Drugs]]


==NITROPRESS (sodium nitroprusside) injection, solution, concentrate ==
|indication=


====Label Title====


'''  [[Nitroprusside indications and usage|Indications and Usage]]'''
|hasBlackBoxWarning=
'''| [[Nitroprusside dosage and administration|Dosage and Administration]]'''
Yes
'''| [[Nitroprusside contraindications|Contraindications]]'''
'''| [[Nitroprusside warnings and precautions|Warnings and Precautions]]'''
'''| [[Nitroprusside adverse reactions|Adverse Reactions]]'''
'''| [[Nitroprusside drug interactions|Drug Interactions]]'''
'''| [[Nitroprusside use in specific populations|Use in Specific Populations]]'''
'''| [[Nitroprusside overdosage|Overdosage]]'''
'''| [[Nitroprusside description|Description]]'''
'''| [[Nitroprusside clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Nitroprusside nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Nitroprusside clinical studies|Clinical Studies]]'''
'''| [[Nitroprusside how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Nitroprusside labels and packages|Labels and Packages]]'''


==Mechanism of Action==
|adverseReactions=




==References==
<!--Black Box Warning-->


{{Reflist|2}}
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|fdaLIADAdult=
 
=====Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
* Dosing Information
 
:* Dosage
 
=====Condition3=====
 
* Dosing Information
 
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=====Condition4=====
 
* Dosing Information
 
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|offLabelAdultGuideSupport=
 
=====Condition1=====
 
* Developed by:
 
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|offLabelAdultNoGuideSupport=
 
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<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
 
|fdaLIADPed=
 
=====Condition1=====
 
* Dosing Information
 
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=====Condition2=====
 
There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.
 
 
<!--Off-Label Use and Dosage (Pediatric)-->
 
<!--Guideline-Supported Use (Pediatric)-->
 
|offLabelPedGuideSupport=
 
=====Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
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|offLabelPedNoGuideSupport=
 
=====Condition1=====
 
* Dosing Information
 
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|contraindications=
 
* Condition1
 
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======Central Nervous System======
 
 
 
======Cardiovascular======
 
 
 
======Respiratory======
 
 
 
======Gastrointestinal======
 
 
 
======Hypersensitivity======
 
 
 
======Miscellaneous======
 
 
 
<!--Postmarketing Experience-->
 
|postmarketing=
 
There is limited information regarding <i>Postmarketing Experience</i> of {{PAGENAME}} in the drug label.
 
======Central Nervous System======
 
 
 
======Cardiovascular======
 
 
 
======Respiratory======
 
 
 
======Gastrointestinal======
 
 
 
======Hypersensitivity======
 
 
 
======Miscellaneous======
 
 
 
<!--Drug Interactions-->
 
|drugInteractions=
 
* Drug
:* Description
 
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|useInPregnancyFDA=
* '''Pregnancy Category'''
 
|useInPregnancyAUS=
* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
 
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|useInLaborDelivery=
There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
 
 
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|useInGeri=
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|useInGender=
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|useInRace=
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|useInRenalImpair=
There is no FDA guidance on the use of {{PAGENAME}} in patients with renal impairment.
 
 
|useInHepaticImpair=
There is no FDA guidance on the use of {{PAGENAME}} in patients with hepatic impairment.
 
 
|useInReproPotential=
There is no FDA guidance on the use of {{PAGENAME}} in women of reproductive potentials and males.
 
 
|useInImmunocomp=
There is no FDA guidance one the use of {{PAGENAME}} in patients who are immunocompromised.
 
<!--Administration and Monitoring-->
 
|administration=
Oral
 
Intravenous
 
|monitoring=
 
There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
 
=====Condition1=====
 
Description
 
<!--IV Compatibility-->
 
|IVCompat=
 
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<!--Overdosage-->
 
|overdose=
 
===Acute Overdose===
 
====Signs and Symptoms====
 
Description
 
====Management====
 
Description
 
===Chronic Overdose===
 
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<!--Pharmacology-->
 
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<!--Mechanism of Action-->
 
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<!--Pharmacodynamics-->
 
|PD=
There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.
 
 
<!--Pharmacokinetics-->
 
|PK=
There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.
 
<!--Nonclinical Toxicology-->
 
|nonClinToxic=
 
There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.
 
<!--Clinical Studies-->
 
|clinicalStudies=
 
There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.
 
=====Condition1=====
 
Description
 
<!--How Supplied-->
 
|howSupplied=
 
<!--Patient Counseling Information-->
 
|fdaPatientInfo=
 
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<!--Precautions with Alcohol-->
 
|alcohol=
Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
 
<!--Brand Names-->
 
|brandNames=
 
<!--Look-Alike Drug Names-->
 
|lookAlike=
* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>
 
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<!--Pill Image-->
 
{{PillImage
|fileName=No image.jpg|This image is provided by the National Library of Medicine.
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<!--Label Display Image-->
 
{{LabelImage
|fileName=No image.jpg|This image is provided by the National Library of Medicine.
}}
 
<!--Category-->


[[Category:Cyanides]]
[[Category:Vasodilators]]
[[Category:Coordination compounds]]
[[Category:World Health Organization essential medicines]]
[[Category:Iron compounds]]
[[Category:Nitrosyl compounds]]
[[Category:Cardiovascular Drugs]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
[[Category:Drug]]

Revision as of 16:44, 4 July 2014

Nitroprusside
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

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Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName: Content

Overview

Nitroprusside is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Nitroprusside in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Nitroprusside in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Nitroprusside in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Nitroprusside in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Nitroprusside in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName: Content

Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Nitroprusside in the drug label.

Central Nervous System
Cardiovascular
Respiratory
Gastrointestinal
Hypersensitivity
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Nitroprusside in the drug label.

Central Nervous System
Cardiovascular
Respiratory
Gastrointestinal
Hypersensitivity
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Nitroprusside in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Nitroprusside during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Nitroprusside with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Nitroprusside with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Nitroprusside with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Nitroprusside with respect to specific gender populations.

Race

There is no FDA guidance on the use of Nitroprusside with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Nitroprusside in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Nitroprusside in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Nitroprusside in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Nitroprusside in patients who are immunocompromised.

Administration and Monitoring

Administration

Oral

Intravenous

Monitoring

There is limited information regarding Monitoring of Nitroprusside in the drug label.

Condition1

Description

IV Compatibility

There is limited information regarding IV Compatibility of Nitroprusside in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

Description

Management

Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Nitroprusside in the drug label.

Pharmacology

There is limited information regarding Nitroprusside Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Nitroprusside Mechanism of Action in the drug label.

Structure

There is limited information regarding Structure of Nitroprusside in the drug label.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Nitroprusside in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Nitroprusside in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Nitroprusside in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Nitroprusside in the drug label.

Condition1

Description

How Supplied

There is limited information regarding Nitroprusside How Supplied in the drug label.

Storage

There is limited information regarding Nitroprusside Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Nitroprusside |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Nitroprusside |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Nitroprusside in the drug label.

Precautions with Alcohol

Alcohol-Nitroprusside interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Nitroprusside Brand Names in the drug label.

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ "http://www.ismp.org". External link in |title= (help)


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