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<small>'''''Synonyms / Brand Names:''''' </small>
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{{Nitroprusside}}


==Dosing and Administration==
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'''''For patient information about Nitroprusside, click [[Nitroprusside (patient information)|here]].'''''
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[[{{PAGENAME}}#FDA Package Insert Resources|FDA Package Insert Resources]]
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[http://www.pace-med-apps.com/gfrcalc.htm Calculate Creatine Clearance]
<br></font size><small>On line calculator of your patients Cr Cl by a variety of formulas.</small><font size="4"><br>
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[http://home.earthlink.net/~sensei11/convert.htm Convert pounds to Kilograms]
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<br> [[{{PAGENAME}}#Publication Resources|Publication Resources]]
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[[{{PAGENAME}}#Trial Resources|Trial Resources]]
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==FDA Package Insert Resources==
{{SB}} NITROPRESS<sup>®</sup>
[[{{PAGENAME}} indications|Indications]]
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[[{{PAGENAME}} contraindications|Contraindications]]
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[[{{PAGENAME}} side effects|Side Effects]]
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[[{{PAGENAME}} drug interactions|Drug Interactions]]
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[[{{PAGENAME}} precautions|Precautions]]
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[[{{PAGENAME}} overdose|Overdose]]
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[[{{PAGENAME}} instructions for administration|Instructions for Administration]]
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[[{{PAGENAME}} how supplied|How Supplied]]
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[[{{PAGENAME}} pharmacokinetics and molecular data|Pharmacokinetics and Molecular Data]]
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[[FDA label]]
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[http://google2.fda.gov/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&x=0&y=0&client=FDA&site=FDA&lr=&proxystylesheet=FDA&output=xml_no_dtd&getfields=* FDA on {{PAGENAME}}]
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==Publication Resources==
==Overview==
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on {{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}]
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28%28N+Engl+J+Med%5Bta%5D%29+OR+%28Lancet%5Bta%5D%29+OR+%28BMJ%5Bta%5D%29%29 Articles on {{PAGENAME}} in N Eng J Med, Lancet, BMJ]
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[[WikiDoc state of the art review on {{PAGENAME}}|WikiDoc State of the Art Review]]
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[http://books.google.com/books?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search&sa=N&tab=gp Textbook Information on {{PAGENAME}}]
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==Trial Resources==
'''Sodium nitroprusside''' is an [[inorganic compound]] with the [[chemical formula|formula]] Na<sub>2</sub>[Fe(CN)<sub>5</sub>NO], usually encountered as the [[water of crystallization|dihydrate]], Na<sub>2</sub>[Fe(CN)<sub>5</sub>NO]·2H<sub>2</sub>O.<ref>{{cite journal| title=Non-Heme Iron Nitrosyls in Biology |author= A. R. Butler, I. L. Megson| journal=Chemical Reviews |year=2002|volume= 102| pages= 1155–1165| doi=10.1021/cr000076d| issue=4}}
[http://clinicaltrials.gov/search/open/condition={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Ongoing Trials with {{PAGENAME}} at Clinical Trials.gov]
</ref> This red-colored sodium salt dissolves in water ethanol to give solutions containing the free [[coordination complex|complex]] dianion [Fe(CN)<sub>5</sub>NO]<sup>2−</sup>.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28randomized+controlled+trial%5BPublication+Type%5D+OR+%28randomized%5BTitle%2FAbstract%5D+AND+controlled%5BTitle%2FAbstract%5D+AND+trial%5BTitle%2FAbstract%5D%29%29 Trial Results with {{PAGENAME}}]
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==Guidelines & Evidence Based Medicine Resources==
This compound is used as a drug. In this role it is abbreviated '''SNP''', and it has tradenames like '''Nitropress'''. It acts as a drug by releasing [[Biological functions of nitric oxide|nitric oxide]]; it belongs to the class of [[NO-releasing drug]]s as a result. This drug is used as a [[vasodilator]] to reduce blood pressure. It has also been used to treat other conditions, and it has been successfully tried as treatment for [[schizophrenia]]. Sodium nitroprusside is also used as an analytical reagent for the detection of methyl ketones, and for the detection of amines that are often found in illicit drugs.
[http://www.guideline.gov/search/searchresults.aspx?Type=3&txtSearch={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&num=20 US National Guidelines Clearinghouse on {{PAGENAME}}]
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:({{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}) AND (Cochrane Database Syst Rev[ta])}} Cochrane Collaboration on {{PAGENAME}}]
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:({{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}) AND (Cost effectiveness)}} Cost Effectiveness of {{PAGENAME}}]
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==Media Resources==
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[http://video.google.com/videosearch?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&um=1&sa=N&tab=fv# Videos on {{PAGENAME}}]
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==Patient Resources==
Cyanides;Vasodilators;Coordination compounds;World Health Organization essential medicines;Ironcompounds;Nitrosylcompounds;Cardiovascular Drugs
[[{{PAGENAME}} (patient information)|Patient Information from National Library of Medicine]]
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[http://www.google.com/search?hl=en&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+more:for_patients&cx=disease_for_patients&sa=N&oi=cooptsr&resnum=0&ct=col3&cd=1  Patient Resources on {{PAGENAME}}]
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[http://www.google.com/search?hl=en&client=firefox-a&rls=org.mozilla:en-US:official&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+more:patient_handouts&cx=disease_for_health_professionals&sa=N&oi=coopctx&resnum=0&ct=col1&cd=3 Patient Handouts on {{PAGENAME}}]
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==International Resources==
==NITROPRESS (sodium nitroprusside) injection, solution, concentrate ==
[http://www.google.com/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+en+espanol&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a {{PAGENAME}} en Español]
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{{FDA}}


====Label Title====
'''  [[Nitroprusside indications and usage|Indications and Usage]]'''
'''| [[Nitroprusside dosage and administration|Dosage and Administration]]'''
'''| [[Nitroprusside dosage forms and strengths|Dosage Forms and Strengths]]'''
'''| [[Nitroprusside contraindications|Contraindications]]'''
'''| [[Nitroprusside warnings and precautions|Warnings and Precautions]]'''
'''| [[Nitroprusside adverse reactions|Adverse Reactions]]'''
'''| [[Nitroprusside drug interactions|Drug Interactions]]'''
'''| [[Nitroprusside use in specific populations|Use in Specific Populations]]'''
'''| [[Nitroprusside overdosage|Overdosage]]'''
'''| [[Nitroprusside description|Description]]'''
'''| [[Nitroprusside clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Nitroprusside nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Nitroprusside clinical studies|Clinical Studies]]'''
'''| [[Nitroprusside how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Nitroprusside patient counseling information|Patient Counseling Information]]'''
'''| [[Nitroprusside labels and packages|Labels and Packages]]'''
==Mechanism of Action==
==References==
{{Reflist|2}}
{{Nonsympatholytic vasodilatory antihypertensives}}
[[Category:Cyanides]]
[[Category:Vasodilators]]
[[Category:Coordination compounds]]
[[Category:World Health Organization essential medicines]]
[[Category:Iron compounds]]
[[Category:Nitrosyl compounds]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
[[Category:Drugs]]

Revision as of 15:16, 27 February 2014


Nitroprusside
NITROPRESS® FDA Package Insert
Indications and Usage
Dosage and Administration
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Labels and Packages
Clinical Trials on Nitroprusside
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2] For patient information about Nitroprusside, click here.

Synonyms / Brand Names: NITROPRESS®

Overview

Sodium nitroprusside is an inorganic compound with the formula Na2[Fe(CN)5NO], usually encountered as the dihydrate, Na2[Fe(CN)5NO]·2H2O.[1] This red-colored sodium salt dissolves in water ethanol to give solutions containing the free complex dianion [Fe(CN)5NO]2−.

This compound is used as a drug. In this role it is abbreviated SNP, and it has tradenames like Nitropress. It acts as a drug by releasing nitric oxide; it belongs to the class of NO-releasing drugs as a result. This drug is used as a vasodilator to reduce blood pressure. It has also been used to treat other conditions, and it has been successfully tried as treatment for schizophrenia. Sodium nitroprusside is also used as an analytical reagent for the detection of methyl ketones, and for the detection of amines that are often found in illicit drugs.

Category

Cyanides;Vasodilators;Coordination compounds;World Health Organization essential medicines;Ironcompounds;Nitrosylcompounds;Cardiovascular Drugs

NITROPRESS (sodium nitroprusside) injection, solution, concentrate

Label Title

Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Mechanism of Action

References

  1. ↑ A. R. Butler, I. L. Megson (2002). "Non-Heme Iron Nitrosyls in Biology". Chemical Reviews. 102 (4): 1155–1165. doi:10.1021/cr000076d.

Template:Nonsympatholytic vasodilatory antihypertensives

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