Niclosamide

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Niclosamide
YOMESAN^® Package Insert
Clinical Pharmacology
Indications
Contraindications
Side Effects
Overdosage
Dosage

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Niclosamide is a teniacide ("tenia-" referring to tapeworm) in the anthelmintic family especially effective against cestodes that infect humans.

It is stressed that while anthelmintics are a drug familiy used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against worms such as pinworms or roundworms.

It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.

Niclosamide molecules are lethal to tapeworms upon contact.

US Brand Names

NICLOCIDE^®, YOMESAN^® (DISCONTINUED)

FDA Package Insert

Mechanism of Action

Niclosamide uncouples oxidative phosphorylation in the tapeworm.^[1]

References

↑ Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature. 221 (5185): 1016–8.

[pmid-1] Weinbach EC, Garbus J (1969). "Mechanism of action of reagents that uncouple oxidative phosphorylation". Nature. 221 (5185): 1016–8.

[1]