Neutrophil gelatinase-associated lipocalin: Difference between revisions
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*Neutrophil gelatinase-associated lipocalin (NGAL), from the family of lipocalins, is a polypeptide that is secreted following renal [[tubular]] cell injury.<ref name="pmid18569973">{{cite journal| author=Devarajan P| title=Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. | journal=Scand J Clin Lab Invest Suppl | year= 2008 | volume= 241 | issue= | pages= 89-94 | pmid=18569973 | doi=10.1080/00365510802150158 | pmc=2528839 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18569973 }} </ref> <ref name="pmid14514731">{{cite journal| author=Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J | display-authors=etal| title=Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. | journal=J Am Soc Nephrol | year= 2003 | volume= 14 | issue= 10 | pages= 2534-43 | pmid=14514731 | doi=10.1097/01.asn.0000088027.54400.c6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14514731 }} </ref> <ref name="pmid27634444">{{cite journal| author=Shang W, Wang Z| title=The Update of NGAL in Acute Kidney Injury. | journal=Curr Protein Pept Sci | year= 2017 | volume= 18 | issue= 12 | pages= 1211-1217 | pmid=27634444 | doi=10.2174/1389203717666160909125004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27634444 }} </ref> | *Neutrophil gelatinase-associated lipocalin (NGAL), from the family of lipocalins, is a polypeptide that is secreted following renal [[tubular]] cell injury.<ref name="pmid18569973">{{cite journal| author=Devarajan P| title=Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. | journal=Scand J Clin Lab Invest Suppl | year= 2008 | volume= 241 | issue= | pages= 89-94 | pmid=18569973 | doi=10.1080/00365510802150158 | pmc=2528839 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18569973 }} </ref> <ref name="pmid14514731">{{cite journal| author=Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J | display-authors=etal| title=Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. | journal=J Am Soc Nephrol | year= 2003 | volume= 14 | issue= 10 | pages= 2534-43 | pmid=14514731 | doi=10.1097/01.asn.0000088027.54400.c6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14514731 }} </ref> <ref name="pmid27634444">{{cite journal| author=Shang W, Wang Z| title=The Update of NGAL in Acute Kidney Injury. | journal=Curr Protein Pept Sci | year= 2017 | volume= 18 | issue= 12 | pages= 1211-1217 | pmid=27634444 | doi=10.2174/1389203717666160909125004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27634444 }} </ref> | ||
*Elevated NGAL levels in the urine and plasma can be used as a useful [[biomarker]] for early diagnosis of [[AKI]] before [[creatinine]] rise or changes in urinary output.<ref name="pmid27634444">{{cite journal| author=Shang W, Wang Z| title=The Update of NGAL in Acute Kidney Injury. | journal=Curr Protein Pept Sci | year= 2017 | volume= 18 | issue= 12 | pages= 1211-1217 | pmid=27634444 | doi=10.2174/1389203717666160909125004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27634444 }} </ref> | *Elevated NGAL levels in the urine and plasma can be used as a useful [[biomarker]] for early diagnosis of [[AKI]] before [[creatinine]] rise or changes in urinary output.<ref name="pmid27634444">{{cite journal| author=Shang W, Wang Z| title=The Update of NGAL in Acute Kidney Injury. | journal=Curr Protein Pept Sci | year= 2017 | volume= 18 | issue= 12 | pages= 1211-1217 | pmid=27634444 | doi=10.2174/1389203717666160909125004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27634444 }} </ref> | ||
Latest revision as of 06:09, 1 July 2020
Synonyms and keywords: NGAL
- Neutrophil gelatinase-associated lipocalin (NGAL), from the family of lipocalins, is a polypeptide that is secreted following renal tubular cell injury.[1] [2] [3]
- Elevated NGAL levels in the urine and plasma can be used as a useful biomarker for early diagnosis of AKI before creatinine rise or changes in urinary output.[3]
- NGAL level is correlated with the severity of AKI.[3]
References
- ↑ Devarajan P (2008). "Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease". Scand J Clin Lab Invest Suppl. 241: 89–94. doi:10.1080/00365510802150158. PMC 2528839. PMID 18569973.
- ↑ Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J; et al. (2003). "Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury". J Am Soc Nephrol. 14 (10): 2534–43. doi:10.1097/01.asn.0000088027.54400.c6. PMID 14514731.
- ↑ 3.0 3.1 3.2 Shang W, Wang Z (2017). "The Update of NGAL in Acute Kidney Injury". Curr Protein Pept Sci. 18 (12): 1211–1217. doi:10.2174/1389203717666160909125004. PMID 27634444.